Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: results and lessons of an underpowered randomised clinical trial

Girlanda, Francesca; Cipriani, Andrea; Agrimi, Emilia; Appino, Maria Grazia; Barichello, Andrea; Beneduce, Rossella; Bighelli, Irene; Bisoffi, Giulia; Bisogno, Alfredo; Bortolaso, Paola; Boso, Marianna; Calandra, Carmela; Cascone, Liliana; Castellazzi, Mariasole; Corbascio, Caterina; Parise, Vincenzo Fricchione; Gardellin, Francesco; Gennaro, Daniele; Hanife, Batul; Lintas, Camilla; Lorusso, Marina; Luca, Antonina; Luca, Maria; Luchetta, Chiara; Lucii, Claudio; Maio, Francesca; Marsilio, Alessandra; Mattei, Chiara; Moretti, Daniele; Nosè, Michela; Occhionero, Guglielmo; Papanti, Duccio; Pecile, Damiano; Percudani, Mauro; Prestia, Davide; Purgato, Marianna; Restaino, Francesco; Romeo, Salvatore; Sciarma, Tiziana; Strizzolo, Stefania; Tamborini, Stefania; Todarello, Orlando; Tozzi, Fiorella; Ziero, Simona; Zotos, Spyridon; Barbui, Corrado

doi:10.1186/1756-0500-7-731

Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: results and lessons of an underpowered randomised clinical trial

As lithium treatment might be effective in reducing the risk of deliberate self-harm (DSH) in adult patients with unipolar affective disorders, we designed a pragmatic randomised trial to assess its efficacy in more than 200 patients with treatment-resistant depression. However, we randomised 56 …