The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis
Open accessAbstract
Background: Antiangiogenic therapy is one of the most significant advances in anticancer treatment. The benefits of antiangiogenic therapies of late-stage cancers have been investigated but are still too limited. Methods: We used an ovarian cancer model to test the effect of short-term bevacizumab treatment on metastasis as measured by bioluminescence. Western blotting and CD34-PAS dual staining were performed to assess hypoxia-inducible transcription factor-1α (HIF-1α) expression and vasculogenic mimicry(VM) formation. Cell viability was examined by a CCK8 assay. Results: Bevacizumab demonstrated antitumor effects in models of ovarian cancer, but also accelerated metastasis together, with marked hypoxia and VM formation in mice receiving short-term therapy. Bevacizumab treatment did not affect SKOV3 cell viability and the amount of VM in three-dimensional culture. Conclusion: These results suggest that antiangiogenic therapy may potentially influence the progression of metastatic disease, which has been linked to the hypoxic response and VM formation.
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Citations
Cites
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 1×
“Moreover, single-agent use of antiangiogenesis appears to be insufficient to improve patient survival [4].”
BackgroundTransplacental Carcinogenesis by Stilbestrol
Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640
Cited by
Resistance Mechanisms to Anti-angiogenic Therapies in Cancer
Haibe, Y., Kreidieh, M., El Hajj, H., Khalifeh, I., Mukherji, D., Temraz, S., & Shamseddine, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00221 · Cited by 396
Tumor Cell Vasculogenic Mimicry
Seftor, R. E. B., Hess, A. R., Seftor, E. A., Kirschmann, D. A., Hardy, K. M., Margaryan, N. V., & Hendrix, M. J. C. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.07.013 · Cited by 282
Wang, F., Sun, W., Zhang, J., & Fan, Y. (2019) · Oncology Letters · doi:10.3892/ol.2019.9973 · Cited by 115
Metadata
- Authors
- Xu, Y., Li, Q., Li, X.-Y., Yang, Q.-Y., Xu, W.-W., & Liu, G.-L.
- Venue
- Journal of Experimental & Clinical Cancer Research
- Published
- 2012-02-23
- Volume
- 31
- Issue
- 1
- Pages
- 16-16
- ISSN
- 0392-9078 (ISSN-L)
- 1756-9966
- OpenAlex
- W2097089862
- Cited by
- 160
- References
- 2
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xu, Y., Li, Q., Li, X.-Y., Yang, Q.-Y., Xu, W.-W., & Liu, G.-L. (2012). Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/1756-9966-31-16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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