Cited by 2,640Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsCarcinogens and Genotoxicity Assessment

Transplacental Carcinogenesis by Stilbestrol

Folkman, Judah·1971·New England Journal of Medicine

Abstract

Herbst, Ulfelder and Poskanzer1 were the first to notice a high correlation between adenocarcinoma of the vagina in adolescent girls and prior maternal ingestion of diethylstilbestrol. This is a stunning observation. It is supported by five more cases described in this issue by Greenwald et al. In a previous editorial2 Langmuir discussed some clinical and scientific implications of this discovery. Further speculations are now warranted.Neither Herbst nor Greenwald studied a large number of mothers with repeated bleeding or previous pregnancy loss who did not receive stilbestrol. This omission is irrelevant, however, because of the extreme rarity of adenocarcinoma of . . .

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Crossref · 10.1056/nejm197108122850711

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  • The ability of tumor cells to induce new blood vessel formation is essential for tumor growth and metastatic cancer dissemination.

    “The ability of tumor cells to induce new blood vessel formation is essential for tumor growth and metastatic cancer dissemination44,263.”

    From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [44]

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Authors
Folkman, J.
Corresponding author
Folkman, Judah
Venue
New England Journal of Medicine
Published
1971-08-12
Volume
285
Issue
7
Pages
404-405
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2054728198
Cited by
2,640
References
4
Citations by year
2026: 3 · 2025: 12 · 2024: 13 · 2023: 12 · 2022: 19 · 2021: 46 · 2020: 44 · 2019: 57 · 2018: 61 · 2017: 79 · 2016: 88 · 2015: 113 · 2014: 105 · 2013: 139 · 2012: 152
FWCI
14.72
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
diethylstilbestrol, transplacental carcinogenesis, vaginal adenocarcinoma, adolescent girls, maternal exposure, miscarriage, endometrial cancer
MeSH terms
Adenocarcinoma, Age Factors, Carcinogens, Diethylstilbestrol, Female, Humans, Maternal-Fetal Exchange, Pregnancy, Pregnancy Complications, Vaginal Neoplasms

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