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Cited by 115Angiogenesis and VEGF in CancerCancer Cells and MetastasisTGF-β signaling in diseases

Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)

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Wang, Fang‑Tao, Sun, Wei, Zhang, Jing‑Tao, Fan, Yue‑Zu·2019·Oncology Letters
DOI 10.3892/ol.2019.9973PMC PMC6396119
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Abstract

Adequate blood supply is essential for tumor survival, growth and metastasis. The tumor microenvironment (TME) is dynamic and complex, comprising cancer cells, cancer-associated stromal cells and their extracellular products. The TME serves an important role in tumor progression. Cancer-associated fibroblasts (CAFs) are the principal component of stromal cells within the TME, and contribute to tumor neo-angiogenesis by altering the proteome and degradome. The present paper reviews previous studies of the molecular signaling pathways by which CAFs promote tumor neo-angiogenesis and highlights therapeutic response targets. Also discussed are potential strategies for antitumor neo-angiogenesis to improve tumor treatment efficacy.

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Cited by

Sorted by citations

Authors
Wang, F., Sun, W., Zhang, J., & Fan, Y.
Affiliations
  • Tongji University (CN)
  • Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China
Corresponding author
Fan, Yue‑Zu
ORCID
Venue
Oncology Letters
Publisher
Spandidos Publications
Published
2019-01-25
Volume
17
Issue
3
Pages
3055-3065
ISSN
  • 1792-1074 (ISSN-L)
  • 1792-1082
DOI
10.3892/ol.2019.9973
PMC
PMC6396119
OpenAlex
W2914714363
Cited by
115
References
4
Citations by year
2026: 4 · 2025: 15 · 2024: 17 · 2023: 19 · 2022: 16 · 2021: 19 · 2020: 21 · 2019: 4
FWCI
1.32
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Oncology Letters (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81372614, 30672073)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
cancer-associated fibroblasts, tumor neoangiogenesis, tumor microenvironment, tumor stroma, molecular pathways, therapeutic target, tumor progression, metastasis

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