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Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs
Open accessAbstract
Tendon and ligaments have poor healing capacity and when injured often require surgical intervention. Tissue replacement via autografts and allografts are non-ideal strategies that can lead to future problems. As an alternative, scaffold-based tissue engineering strategies are being pursued. In this review, we describe design considerations and major recent advancements of scaffolds for tendon/ligament engineering. Specifically, we outline native tendon/ligament characteristics critical for design parameters and outcome measures, and introduce synthetic and naturally-derived biomaterials used in tendon/ligament scaffolds. We will describe applications of these biomaterials in advanced tendon/ligament engineering strategies including the utility of scaffold functionalization, cyclic strain, growth factors, and interface considerations. The goal of this review is to compile and interpret the important findings of recent tendon/ligament engineering research in an effort towards the advancement of regenerative strategies.
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Cited by
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Sun, W., Gregory, D. A., Tomeh, M. A., & Zhao, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031499 · Cited by 552
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Narayanan, G., Vernekar, V. N., Kuyinu, E. L., & Laurencin, C. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.015 · Cited by 484
Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm
Yang, G., Rothrauff, B. B., & Tuan, R. S. (2013) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21041 · Cited by 469
Self-citationSilk Fibroin in Tissue Engineering
Kasoju, N., & Bora, U. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200097 · Cited by 383
Metadata
- Authors
- Kuo, C. K., Marturano, J. E., & Tuan, R. S.
- Venue
- BMC Sports Science, Medicine and Rehabilitation
- Published
- 2010-08-20
- Volume
- 2
- Issue
- 1
- Pages
- 20-20
- ISSN
- 2052-1847 (ISSN-L)
- OpenAlex
- W2005114411
- Cited by
- 179
- References
- 0
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs. https://app.cochat.ai/papers/10.1186/1758-2555-2-20
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- Kuo, C. K., Marturano, J. E., & Tuan, R. S. (2010). Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs. BMC Sports Science, Medicine and Rehabilitation. https://doi.org/10.1186/1758-2555-2-20
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