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Is exercise a therapeutic tool for improvement of cardiovascular risk factors in adolescents with type 1 diabetes mellitus? A randomised controlled trial
Open accessAbstract
BACKGROUND: Type 1 diabetes mellitus (T1DM) is associated with a high risk for early atherosclerotic complications especially risk of coronary heart disease. OBJECTIVE: To evaluate the impact of six months exercise prgram on glycemic control, plasma lipids values, blood pressure, severity and frequency of hypoglycemia, anthropometric measurements and insulin dose in a sample of adolescents with T1DM. RESEARCH DESIGN AND METHODS: A total of 196 type 1 diabetic patients participated in the study. They were classified into three groups: Group (A) did not join the exercise program(n = 48), group (B) attended the exercise sessions once/week (n = 75), group (C) attended the exercise sessions three times/week (n = 73). Studied parameters were evaluated before and six months after exercise programe. RESULTS: Exercise improved glycemic control by reducing HbA1c values in exercise groups (P = 0.03, P = 0.01 respectively) and no change in those who were not physically active (P = 0.2). Higher levels of HbA1c were associated with higher levels of cholesterol, LDL-c, and triglycerides (P = 0.000 each). In both groups, B and C, frequent exercise improved dyslipidemia and reduced insulin requirements significantly (P = 0.00 both), as well as a reduction in BMI (P = 0.05, P = 0.00 respectively) and waist circumference(P = 0.02, P = 0.00 respectively). The frequency of hypoglycemic attacks were not statistically different between the control group and both intervention groups (4.7 +/- 3.56 and 4.82 +/- 4.23, P = 0.888 respectively). Reduction of blood pressure was statistically insignificant apart from the diastolic blood presure in group C (P = 0.04). CONCLUSION: Exercise is an indispensable component in the medical treatment of patients with T1DM as it improves glycemic control and decreases cardiovascular risk factors among them.
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Metadata
- Authors
- Salem, M. A., AboElAsrar, M. A., Elbarbary, N. S., ElHilaly, R. A., & Refaat, Y. M.
- Affiliations
- Ain Shams University (EG)
- Corresponding author
- Salem, Mona A
- ORCID
- Elbarbary, Nancy S
- Venue
- Diabetology & Metabolic Syndrome
- Published
- 2010-07-11
- Volume
- 2
- Issue
- 1
- Pages
- 47-47
- ISSN
- 1758-5996 (ISSN-L)
- PMC
- PMC3238209
- OpenAlex
- W2142357242
- Cited by
- 140
- References
- 40
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 4 · 2022: 11 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 11 · 2012: 6
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetology & Metabolic Syndrome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- Ain Shams University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 1 diabetes, adolescents, exercise therapy, glycemic control, HbA1c, dyslipidemia, cardiovascular risk factors, insulin dose, hypoglycemia, body mass index, waist circumference, blood pressure
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