The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Is exercise a therapeutic tool for improvement of cardiovascular risk factors in adolescents with type 1 diabetes mellitus? A randomised controlled trial
Open accessAbstract
BACKGROUND: Type 1 diabetes mellitus (T1DM) is associated with a high risk for early atherosclerotic complications especially risk of coronary heart disease. OBJECTIVE: To evaluate the impact of six months exercise prgram on glycemic control, plasma lipids values, blood pressure, severity and frequency of hypoglycemia, anthropometric measurements and insulin dose in a sample of adolescents with T1DM. RESEARCH DESIGN AND METHODS: A total of 196 type 1 diabetic patients participated in the study. They were classified into three groups: Group (A) did not join the exercise program(n = 48), group (B) attended the exercise sessions once/week (n = 75), group (C) attended the exercise sessions three times/week (n = 73). Studied parameters were evaluated before and six months after exercise programe. RESULTS: Exercise improved glycemic control by reducing HbA1c values in exercise groups (P = 0.03, P = 0.01 respectively) and no change in those who were not physically active (P = 0.2). Higher levels of HbA1c were associated with higher levels of cholesterol, LDL-c, and triglycerides (P = 0.000 each). In both groups, B and C, frequent exercise improved dyslipidemia and reduced insulin requirements significantly (P = 0.00 both), as well as a reduction in BMI (P = 0.05, P = 0.00 respectively) and waist circumference(P = 0.02, P = 0.00 respectively). The frequency of hypoglycemic attacks were not statistically different between the control group and both intervention groups (4.7 +/- 3.56 and 4.82 +/- 4.23, P = 0.888 respectively). Reduction of blood pressure was statistically insignificant apart from the diastolic blood presure in group C (P = 0.04). CONCLUSION: Exercise is an indispensable component in the medical treatment of patients with T1DM as it improves glycemic control and decreases cardiovascular risk factors among them.
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“Physical activity, a known determinant of insulin requirements 25 , 26 , was not assessed.”
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“Other studies [23-25] also revealed that the more frequent exercise performed the lower HbA1c level.”
BackgroundResultPhysical Activity/Exercise and Diabetes
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Huynh, K., Bernardo, B. C., McMullen, J. R., & Ritchie, R. H. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.01.003 · Cited by 556
Type 1 Diabetes Mellitus and Cardiovascular Disease
de Ferranti, S. D., de Boer, I. H., Fonseca, V. A., Fox, C. S., Golden, S. H., Lavie, C. J., Magge, S. N., Marx, N., McGuire, D. K., Orchard, T. J., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000034 · Cited by 516
What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review
Chimen, M., Kennedy, A., Nirantharakumar, K., Pang, T. T., Andrews, R., & Narendran, P. (2012) · Diabetologia · doi:10.1007/s00125-011-2403-2 · Cited by 438
de Ferranti, S. D., de Boer, I. H., Fonseca, V. A., Fox, C. S., Golden, S. H., Lavie, C. J., Magge, S. N., Marx, N., McGuire, D. K., Orchard, T. J., et al. (2014) · Diabetes Care · doi:10.2337/dc14-1720 · Cited by 444
Metadata
- Authors
- Salem, M. A., AboElAsrar, M. A., Elbarbary, N. S., ElHilaly, R. A., & Refaat, Y. M.
- Affiliations
- Ain Shams University (EG)
- Corresponding author
- Salem, Mona A
- ORCID
- Elbarbary, Nancy S
- Venue
- Diabetology & Metabolic Syndrome
- Published
- 2010-07-11
- Volume
- 2
- Issue
- 1
- Pages
- 47-47
- ISSN
- 1758-5996 (ISSN-L)
- PMC
- PMC3238209
- OpenAlex
- W2142357242
- Cited by
- 140
- References
- 40
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 4 · 2022: 11 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 11 · 2012: 6
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetology & Metabolic Syndrome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- Ain Shams University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 1 diabetes, adolescents, exercise therapy, glycemic control, HbA1c, dyslipidemia, cardiovascular risk factors, insulin dose, hypoglycemia, body mass index, waist circumference, blood pressure
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