The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Visceral adiposity, insulin resistance and cancer risk
Open accessAbstract
BACKGROUND: There is a well established link between obesity and cancer. Emerging research is characterising this relationship further and delineating the specific role of excess visceral adiposity, as opposed to simple obesity, in promoting tumorigenesis. This review summarises the evidence from an epidemiological and pathophysiological perspective. METHODS: Relevant medical literature was identified from searches of PubMed and references cited in appropriate articles identified. Selection of articles was based on peer review, journal and relevance. RESULTS: Numerous epidemiological studies consistently identify increased risk of developing carcinoma in the obese. Adipose tissue, particularly viscerally located fat, is metabolically active and exerts systemic endocrine effects. Putative pathophysiological mechanisms linking obesity and carcinogenesis include the paracrine effects of adipose tissue and systemic alterations associated with obesity. Systemic changes in the obese state include chronic inflammation and alterations in adipokines and sex steroids. Insulin and the insulin-like growth factor axis influence tumorigenesis and also have a complex relationship with adiposity. There is evidence to suggest that insulin and the IGF axis play an important role in mediating obesity associated malignancy. CONCLUSIONS: There is much evidence to support a role for obesity in cancer progression, however further research is warranted to determine the specific effect of excess visceral adipose tissue on tumorigenesis. Investigation of the potential mechanisms underpinning the association, including the role of insulin and the IGF axis, will improve understanding of the obesity and cancer link and may uncover targets for intervention.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“corroborating the hypothesis that visceral obesity favors insulin resistance, as demonstrated in several previous studies [35,36,37].”
From MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches (2018) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
(2000) · PubMed · Cited by 13,173
Obesity : Preventing and managing the global epidemic
Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J.-L., Bray, G. A., Carroll, K. N., Chitson, P., Chen, C., Dietz, W. H., Hill, J. O., et al. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 12,945
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The environment and disease: association or causation?
Hill, A. B. (2015) · Journal of the Royal Society of Medicine · doi:10.1177/0141076814562718 · Cited by 7,804
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
The Environment and Disease: Association or Causation?
Hill, A. B. (1965) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576505800503 · Cited by 6,974
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Research works printed but not linked: 3
- Calle EE, Kaaks R: Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004, 579-591.
- Wajchenberg BL: Subcutaneous and Visceral Adipose Tissue: Their Relation to the MetabolicSyndrome. Endocr Rev. 2000, 21: 697-738. 10.1210/er.21.6.697. · DOI · Paper page
- Giovannucci E: Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. The American Journal of Clinical Nutrition. 2007, 86: 836S-842S. · DOI
Cited by
Sorted by citations
Bardou, M., Barkun, A. N., & Martel, M. (2013) · Gut · doi:10.1136/gutjnl-2013-304701 · Cited by 844
Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts
Trinchieri, G. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075008 · Cited by 522
Eheman, C. R., Henley, S. J., Ballard-Barbash, R. R., Jacobs, E. J., Schymura, M. J., Noone, A., Pan, L., Anderson, R. N., Fulton, J. E., Kohler, B., et al. (2012) · Cancer · doi:10.1002/cncr.27514 · Cited by 465
Keum, N., Greenwood, D. C., Lee, D. H., Kim, R., Aune, D., Ju, W., Hu, F. B., & Giovannucci, E. L. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv088 · Cited by 407
Epidemiology of Colorectal Cancer
Keum, N., & Giovannucci, E. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-35153-7_21 · Cited by 331
Krishnan, J., Danzer, C. F., Simka, T., Ukropec, J., Walter, K., Kumpf, S., Mirtschink, P., Ukropcová, B., Gašperíková, D., Pedrazzini, T., et al. (2012) · Genes & Development · doi:10.1101/gad.180406.111 · Cited by 316
Obesity and cancer: An update of the global impact
Arnold, M., Leitzmann, M. F., Freisling, H., Bray, F., Romieu, I., Renehan, A. G., & Soerjomataram, I. (2016) · Cancer Epidemiology · doi:10.1016/j.canep.2016.01.003 · Cited by 311
de Vathaire, F., El-Fayech, C., Ayed, F. F. B., Haddy, N., Guibout, C., Winter, D., Thomas-Teinturier, C., Veres, C., Jackson, A., Pacquement, H., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70323-6 · Cited by 211
Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer
Aleksandrova, K., Boeing, H., Nöthlings, U., Jenab, M., Fedirko, V., Kaaks, R., Lukanova, A., Trichopoulou, A., Trichopoulos, D., Boffetta, P., et al. (2014) · Hepatology · doi:10.1002/hep.27016 · Cited by 217
Mandelblatt, J. S., Stern, R. A., Luta, G., McGuckin, M., Clapp, J. D., Hurria, A., Jacobsen, P. B., Faul, L. A., Isaacs, C. J., Denduluri, N., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.2050 · Cited by 183
Cohen, C. W., Fontaine, K. R., Arend, R. C., Alvarez, R. D., Leath, C. A., Huh, W. K., Bevis, K. S., Kim, K. H., Straughn, J. M., & Gower, B. A. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy119 · Cited by 164
Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets
Khan, S. U., Shukla, S., Sinha, S., & Meeran, S. M. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.10.001 · Cited by 165
Visceral Obesity and Colorectal Cancer: Are We Missing the Boat with BMI?
Rickles, A. S., Iannuzzi, J. C., Mironov, O., Deeb, A., Sharma, A., Fleming, F. J., & Monson, J. R. T. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-2045-9 · Cited by 155
Chang, H.-H., Moro, A., Takakura, K., Su, H., Mo, A., Nakanishi, M., Waldron, R. T., French, S. W., Dawson, D. W., Hines, O. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184455 · Cited by 145
Resistin: Insulin resistance to malignancy
Codoñer‐Franch, P., & Alonso‐Iglesias, E. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.07.043 · Cited by 145
Castillo, J. J., Reagan, J. L., Ingham, R. R., Furman, M. S., Dalia, S. M., Merhi, B., Nemr, S., Zarrabi, A. J., & Mitri, J. (2012) · Leukemia Research · doi:10.1016/j.leukres.2011.12.020 · Cited by 139
Kesztyüs, D., Cermak, P., Gulich, M., & Kesztyüs, T. (2019) · Nutrients · doi:10.3390/nu11122854 · Cited by 142
Guaita‐Esteruelas, S., Gumà, J., Masana, L., & Borràs, J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.002 · Cited by 135
Rustgi, V. K., Li, Y., Gupta, K., Minacapelli, C. D., Bhurwal, A., Catalano, C., & Elsaid, M. I. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.03.021 · Cited by 125
Should visceral fat be reduced to increase longevity?
Finelli, C., Sommella, L., Gioia, S., Sala, N. L., & Tarantino, G. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.007 · Cited by 118
Molecular Links between Central Obesity and Breast Cancer
Zimța, A., Țigu, A. B., Muntean, M. V., Cenariu, D., Slaby, O., & Berindan‐Neagoe, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215364 · Cited by 96
Faris, M. E., Madkour, M. I., Obaideen, A. K., Dalah, E. Z., Hasan, H. A., Radwan, H. M., Jahrami, H., Hamdy, O., & Mohammad, M. G. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.05.023 · Cited by 91
Sebastiano, K. M. D., & Mourtzakis, M. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-079 · Cited by 92
Obesity, sleep apnea, and cancer
Almendros, I., Martínez‐García, M. Á., Farré, R., & Gozal, D. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0549-z · Cited by 93
Neamat‐Allah, J., Wald, D., Hüsing, A., Teucher, B., Wendt, A. T., Delorme, S., Dinkel, J., Vigl, M., Bergmann, M. M., Feller, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091586 · Cited by 86
Daily Aspirin Use and Cancer Mortality in a Large US Cohort
Jacobs, E. J., Newton, C. C., Gapstur, S. M., & Thun, M. J. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs318 · Cited by 86
Visceral adiposity and cancer survival: a review of imaging studies
Xiao, J., Mazurak, V. C., Olobatuyi, T. A., Caan, B. J., & Prado, C. M. M. (2016) · European Journal of Cancer Care · doi:10.1111/ecc.12611 · Cited by 89
Keum, N., Greenwood, D. C., Lee, D. H., Kim, R., Aune, D., Ju, W., Hu, F. B., & Giovannucci, E. L. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju428 · Cited by 87
Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer
Fleming, C., O’Connell, E., Kavanagh, R. G., O’Leary, D. P., Twomey, ., Corrigan, M. A., Wang, J. H., Maher, M. M., O’Connor, O. J., & Redmond, H. P. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.15274 · Cited by 86
Visceral adiposity and colorectal adenomas: dose-response meta-analysis of observational studies
Keum, N., Lee, D. H., Kim, R., Greenwood, D. C., & Giovannucci, E. L. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu563 · Cited by 80
Silveira, É. A., Vaseghi, G., Santos, A. S. E. A. D. C., Kliemann, N., Masoudkabir, F., Noll, M. A., Mohammadifard, N., Sarrafzadegan, N., & de Oliveira, C. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239042 · Cited by 84
Kaplan‐Lewis, E., Aberg, J. A., & Lee, M.-K. (2017) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2017.04.002 · Cited by 80
Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study
Arthur, R., Kabat, G. C., Kim, M., Wild, R. A., Shadyab, A. H., Wactawski‐Wende, J., Ho, G. Y. F., Reeves, K. W., Kuller, L. H., Luo, J., et al. (2019) · Cancer Causes & Control · doi:10.1007/s10552-019-01139-5 · Cited by 71
Visceral adiposity in gastrointestinal and hepatic carcinogenesis
Vongsuvanh, R., George, J., Qiao, L., & van der Poorten, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.038 · Cited by 72
A review of lifestyle and environment risk factors for pancreatic cancer
Zanini, S., Renzi, S., Limongi, A. R., Bellavite, P., Giovinazzo, F., & Bermano, G. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2020.11.040 · Cited by 67
De Lorenzo, A., Noce, A., Moriconi, E., Rampello, T., Marrone, G., Di Daniele, N., & Rovella, V. (2018) · Nutrients · doi:10.3390/nu10040474 · Cited by 68
Li, H., Yang, G., Xiang, Y.-B., Gao, J., Zhang, X., Zheng, W., Yt, G., & Shu, X.-O. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.152 · Cited by 63
Adipocytes in the Tumour Microenvironment
Pallegar, N. K., & Christian, S. L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_1 · Cited by 63
Gupta, A., Majumder, K., Arora, N., Mayo, H., Singh, P. P., Beg, M. S., Hughes, R. S., Singh, S., & Johnson, D. H. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.10.017 · Cited by 62
Holo-Retinol–Binding Protein and Its Receptor STRA6 Drive Oncogenic Transformation
Berry, D. C., Levi, L., & Noy, N. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1052 · Cited by 62
Targeting obesity-related dysfunction in hormonally driven cancers
Rubinstein, M. M. Z., Brown, K. A., & Iyengar, N. M. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01393-y · Cited by 61
The role of obesity in gastrointestinal cancer: evidence and opinion
Donohoe, C. L., O’Farrell, N. J., Doyle, S. L., & Reynolds, J. V. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13501786 · Cited by 61
Minami, S., Ihara, S., Tanaka, T., & Komuta, K. (2020) · World Journal of Oncology · doi:10.14740/wjon1225 · Cited by 56
Murphy, R. A., Reinders, I., Garcia, M. E., Eiríksdóttir, G., Launer, L. J., Benediktsson, R., Gudnason, V. G., Jónsson, P. V., & Harris, T. B. (2014) · Diabetes Care · doi:10.2337/dc14-0293 · Cited by 56
Genkinger, J. M., Wu, K., Wang, M., Albanes, D., Black, A., van den Brandt, P. A., Burke, K. A., Cook, M. B., Gapstur, S. M., Giles, G. G., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2019.09.007 · Cited by 54
NCI's provocative questions on cancer: some answers to ignite discussion
Blagosklonny, M. V. (2011) · Oncotarget · doi:10.18632/oncotarget.432 · Cited by 51
Metabolic syndrome, metabolic components, and their relation to the risk of pancreatic cancer
Park, S. K., Oh, C., Kim, M. H., Ha, E., Choi, Y., & Ryoo, J. (2020) · Cancer · doi:10.1002/cncr.32737 · Cited by 50
Mentoor, I., Engelbrecht, A., van Jaarsveld, P. J., & Nell, T. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00758 · Cited by 52
Visceral Obesity, Metabolic Syndrome, and Esophageal Adenocarcinoma
Elliott, J. A., & Reynolds, J. V. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.627270 · Cited by 49
Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
Suba, Z. (2013) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892811308020004 · Cited by 49
Gou, R., Dou, D., Tian, M., Chang, X., Zhao, Y., Meng, X., & Li, G. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1403858 · Cited by 46
Perez‐Cornago, A., Dunneram, Y., Watts, E. L., Key, T. J., & Travis, R. C. (2022) · BMC Medicine · doi:10.1186/s12916-022-02336-x · Cited by 46
Heus, C., Cakir, H., Lak, A., Doodeman, H. J., & Houdijk, A. P. J. (2016) · International Journal of Surgery · doi:10.1016/j.ijsu.2016.03.066 · Cited by 45
Iwase, T., Sangai, T., Fujimoto, H., Sawabe, Y., Matsushita, K., Nagashima, K., Sato, Y., Nakagawa, A., Masuda, T., Nagashima, T., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05467-7 · Cited by 44
Suba, Z. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s52600 · Cited by 46
Obesity-associated cancer: an immunological perspective
Conroy, M. J., Dunne, M. R., Donohoe, C. L., & Reynolds, J. V. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115004176 · Cited by 44
Valentijn, T. M., Galal, W., Hoeks, S. E., van Gestel, Y. R. B. M., Verhagen, H. J. M., & Stolker, R. J. (2013) · World Journal of Surgery · doi:10.1007/s00268-013-2162-y · Cited by 42
Xu, W., Qu, Y., Wang, J., Wang, H., Wan, F., Zhao, J., Zhang, H., & Ye, D. (2019) · Journal of Cancer · doi:10.7150/jca.30989 · Cited by 43
Obesity-related insulin resistance: implications for the surgical patient
Tewari, N., Awad, S., Macdonald, I. A., & Lobo, D. N. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.100 · Cited by 40
Guaita‐Esteruelas, S., Saavedra-García, P., Bosquet, A., Borràs, J., Girona, J., Amiliano, K., Rodríguez-Balada, M., Heras, M., Masana, L., & Gumà, J. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0483 · Cited by 41
Adipocyte Secreted Factors Enhance Aggressiveness of Prostate Carcinoma Cells
Moreira, Â., Pereira, S. S., Costa, M. M., Morais, T., Pinto, A., Fernandes, R., & Monteiro, M. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123217 · Cited by 39
Impact of Visceral Fat on Survival and Metastasis of Stage III Colorectal Cancer
Park, J.-W., Chang, S. Y., Lim, J. S., Park, S. J., Park, J. J., Cheon, J. H., Kim, W. H., & Kim, T. I. (2021) · Gut and Liver · doi:10.5009/gnl20266 · Cited by 39
Lettieri‐Barbato, D., Vegliante, R., Desideri, E., & Ciriolo, M. R. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.02.003 · Cited by 39
Tamboli, R. A., Hajri, T., Jiang, A., Marks–Shulman, P. A., Williams, D. B., Clements, R. H., Melvin, W. V., Bowen, B. P., Shyr, Y., Abumrad, N. N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028577 · Cited by 38
Heus, C., Bakker, N., Verduin, W. M., Doodeman, H. J., & Houdijk, A. P. J. (2019) · World Journal of Surgery · doi:10.1007/s00268-019-04925-z · Cited by 37
De Ridder, J., Julián-Almárcegui, C., Mullee, A., Rinaldi, S., Van Herck, K., Vicente-Rodríguez, G., & Huybrechts, I. (2016) · Cancer Causes & Control · doi:10.1007/s10552-015-0709-y · Cited by 36
Bocca, G., Mastoridis, S., Yeung, T. M., James, D. R. C., & Cunningham, C. (2022) · International Journal of Colorectal Disease · doi:10.1007/s00384-022-04221-8 · Cited by 41
Hata, K., Kubota, M., Shimizu, M., Moriwaki, H., Kuno, T., Tanaka, T., Hara, A., & Hirose, Y. (2012) · Carcinogenesis · doi:10.1093/carcin/bgr323 · Cited by 36
Lim, L., Tan, A. T. B., Moses, K., Rajadhyaksha, V., & Chan, S. P. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.008 · Cited by 34
Filgueira, C. S., Bruno, G., Smith, Z. W., Chua, C. Y. X., Ballerini, A., Folci, M., Gilbert, A. L., Jain, P., Sastry, K. J., Nehete, P. N., et al. (2018) · Biomedical Microdevices · doi:10.1007/s10544-018-0296-2 · Cited by 34
Prognostic role of visceral fat for overall survival in metastatic colorectal cancer: A pilot study
Basile, D., Bartoletti, M., Polano, M., Bortot, L., Gerratana, L., Nardo, P. D., Borghi, M., Fanotto, V., Pelizzari, G., Lisanti, C., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.019 · Cited by 35
Visceral Fat Accumulation Is Associated with Colorectal Cancer in Postmenopausal Women
Lee, J., Lee, H. S., Lee, D., Chu, S. H., Jeon, J. Y., Kim, N. K., & Lee, J.-W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110587 · Cited by 34
Stevens, V. L., Carter, B. D., McCullough, M. L., Campbell, P. T., & Wang, Y. (2019) · Obesity · doi:10.1002/oby.22670 · Cited by 35
Ma, Y., Gao, J., Yin, J., Gu, L., Liu, X., Su, C., Huang, Q., Lu, H., Yang, Y., Zhou, H., et al. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b01030 · Cited by 33
Therapeutic Treatment for Abdominal Obesity in Adults
Kesztyüs, D., Erhardt, J., Schönsteiner, D., & Kesztyüs, T. (2018) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2018.0487 · Cited by 35
Zhang, Y., Zheng, Y., Fu, Y., & Wang, C. (2019) · Adipocyte · doi:10.1080/21623945.2019.1649578 · Cited by 32
Association of interleukin-6 polymorphisms with obesity: A systematic review and meta-analysis
Gholami, M., Sharifi, F., Shahriari, S., Khoshnevisan, K., Larijani, B. A., & Amoli, M. M. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154769 · Cited by 32
Pahk, K., Joung, C., & Kim, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-57937-4 · Cited by 32
Republished: Obesity and colorectal cancer
Bardou, M., Barkun, A. N., & Martel, M. (2013) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2013-304701rep · Cited by 32
Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
Im, S., Park, H., Shon, J., Chung, I.-S., Ho, C.-C., Liu, K.-H., & Song, D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213285 · Cited by 27
Manilla, V., Tommaso, N. D., Santopaolo, F., Gasbarrini, A., & Ponziani, F. R. (2023) · Microorganisms · doi:10.3390/microorganisms11020267 · Cited by 32
Liu, G., Wu, X., Li, Y., Rui, Y., Stocchi, L., Remzi, F. H., & Shen, B. (2016) · Gastroenterology report · doi:10.1093/gastro/gow028 · Cited by 30
Lung cancer and obesity: A contentious relationship (Review)
Georgakopoulou, V., Lempesis, I. G., Τράκας, Ν., Sklapani, P., He, Y., & Spandidos, D. A. (2024) · Oncology Reports · doi:10.3892/or.2024.8817 · Cited by 31
Smith, N. J. G., Caldwell, J. L., van der Merwe, M., Sharma, S., Butawan, M. B., Puppa, M., & Bloomer, R. J. (2019) · Nutrients · doi:10.3390/nu11020350 · Cited by 31
Cheng, T. D., Shankar, J., Zirpoli, G., Roberts, M., Hong, C., Bandera, E. V., Ambrosone, C. B., & Yao, S. (2016) · Cancer Causes & Control · doi:10.1007/s10552-016-0774-x · Cited by 27
Chung, W., Park, J. H., Chung, H. S., Yu, J. M., Kim, D. S., & Moon, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45717-8 · Cited by 27
Han, Q., Kim, S. I., Yoon, S. H., Kim, T. M., Kang, H., Kim, H. J., Cho, J. Y., & Kim, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.741071 · Cited by 27
Kowal, M., KRYST, Ł., Sobiecki, J., & Woronkowicz, A. (2012) · Journal of Biosocial Science · doi:10.1017/s0021932012000284 · Cited by 29
Ota, U., Hara, T., Nakagawa, H., Tsuru, E., Tsuda, M., Kamiya, A., Kuroda, Y., Kitajima, Y., Koda, A., Ishizuka, M., et al. (2017) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0108-3 · Cited by 28
Tahmasebpour, N., Feizi, M. A. H., Ziamajidi, N., Pouladi, N., Montazeri, V., Farhadian, M., & Abbasalipourkabir, R. (2019) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2020.013 · Cited by 27
Kim, J. H., Kim, J. N., Lee, W. J., Seong, H., Choi, H., Ahn, J. Y., Jeong, S. J., Ku, N. S., Son, T., Kim, H., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040494 · Cited by 26
Pérez-Martín, A. R., Castro-Eguiluz, D., Cetina, L., Velasco-Torres, Y., Bahena-González, A., Montes-Servín, E., González-Ibarra, E., Espinosa-Romero, R., & Gallardo‐Rincón, D. (2022) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2021.6963 · Cited by 29
Venniyoor, A. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0185-8 · Cited by 26
Moon, S., Oh, C., Choi, M., Park, Y.-K., Chun, S., Choi, M., Yu, J. M., & Yoo, H. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185127 · Cited by 24
Giudice, A., Crispo, A., Massimiliano, G., D'Arena, G. F., Tecce, M. F., Grimaldi, M., Amore, A., Esposito, E., & Montella, M. (2014) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-1282 · Cited by 24
Prognostic Significance of Sarcopenia in Patients with Unresectable Advanced Esophageal Cancer
Onishi, S., Tajika, M., Tanaka, T., Hirayama, Y., Hara, K., Mizuno, N., Kuwahara, T., Okuno, N., Inaba, Y., Kodaira, T., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101647 · Cited by 24
Abdominal radiation and diabetes: one more piece in the puzzle
Oeffinger, K. C., & Sklar, C. A. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70340-6 · Cited by 23
Visceral Adiposity and Progression of ADPKD: A Cohort Study of Patients From the TEMPO 3:4 Trial
Nowak, K. L., Moretti, F., Bussola, N., Steele, C. N., Gregory, A., Kline, T. L., Ramanathan, S., Trapletti, G. P., Furlanello, C., Mccormick, L., et al. (2024) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2024.02.014 · Cited by 24
Mizuno, R., Miyajima, A., Hibi, T., Masuda, A., Shinojima, T., Kikuchi, E., Jinzaki, M., & Oya, M. (2017) · Medical Oncology · doi:10.1007/s12032-017-0908-3 · Cited by 22
Ye, S., Wen, H., Jiang, Z., & Wu, X. (2016) · BMC Cancer · doi:10.1186/s12885-016-2230-4 · Cited by 22
Metadata
- Authors
- Donohoe, C. L., Doyle, S. L., & Reynolds, J. V.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Reynolds, John V
- Venue
- Diabetology & Metabolic Syndrome
- Published
- 2011-06-22
- Volume
- 3
- Issue
- 1
- Pages
- 12-12
- ISSN
- 1758-5996 (ISSN-L)
- PMC
- PMC3145556
- OpenAlex
- W2119964718
- Cited by
- 247
- References
- 182
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 22 · 2019: 29 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 11 · 2014: 19 · 2013: 15 · 2012: 19
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Diabetology & Metabolic Syndrome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Irish Cancer Society
- Irish Research Council for Science, Engineering and Technology
- Irish Research Council
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- visceral fat, obesity, cancer risk, insulin resistance, insulin-like growth factor axis, adipose tissue endocrine function, adipokines, sex steroids, chronic inflammation, paracrine effects, carcinogenesis, tumor progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
