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Visceral adiposity, insulin resistance and cancer risk
Open accessAbstract
BACKGROUND: There is a well established link between obesity and cancer. Emerging research is characterising this relationship further and delineating the specific role of excess visceral adiposity, as opposed to simple obesity, in promoting tumorigenesis. This review summarises the evidence from an epidemiological and pathophysiological perspective. METHODS: Relevant medical literature was identified from searches of PubMed and references cited in appropriate articles identified. Selection of articles was based on peer review, journal and relevance. RESULTS: Numerous epidemiological studies consistently identify increased risk of developing carcinoma in the obese. Adipose tissue, particularly viscerally located fat, is metabolically active and exerts systemic endocrine effects. Putative pathophysiological mechanisms linking obesity and carcinogenesis include the paracrine effects of adipose tissue and systemic alterations associated with obesity. Systemic changes in the obese state include chronic inflammation and alterations in adipokines and sex steroids. Insulin and the insulin-like growth factor axis influence tumorigenesis and also have a complex relationship with adiposity. There is evidence to suggest that insulin and the IGF axis play an important role in mediating obesity associated malignancy. CONCLUSIONS: There is much evidence to support a role for obesity in cancer progression, however further research is warranted to determine the specific effect of excess visceral adipose tissue on tumorigenesis. Investigation of the potential mechanisms underpinning the association, including the role of insulin and the IGF axis, will improve understanding of the obesity and cancer link and may uncover targets for intervention.
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“corroborating the hypothesis that visceral obesity favors insulin resistance, as demonstrated in several previous studies [35,36,37].”
From MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches (2018) · cites this paper as [36]
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Metadata
- Authors
- Donohoe, C. L., Doyle, S. L., & Reynolds, J. V.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Reynolds, John V
- Venue
- Diabetology & Metabolic Syndrome
- Published
- 2011-06-22
- Volume
- 3
- Issue
- 1
- Pages
- 12-12
- ISSN
- 1758-5996 (ISSN-L)
- PMC
- PMC3145556
- OpenAlex
- W2119964718
- Cited by
- 247
- References
- 182
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 22 · 2019: 29 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 11 · 2014: 19 · 2013: 15 · 2012: 19
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Diabetology & Metabolic Syndrome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Irish Cancer Society
- Irish Research Council for Science, Engineering and Technology
- Irish Research Council
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- visceral fat, obesity, cancer risk, insulin resistance, insulin-like growth factor axis, adipose tissue endocrine function, adipokines, sex steroids, chronic inflammation, paracrine effects, carcinogenesis, tumor progression
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