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Pharmacology of Antihistamines

Church, Diana S, Church, Martin K·2011·World Allergy Organization Journal
DOI 10.1186/1939-4551-4-s3-s22
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FIGURE 1 A, Diagram of a histamine H 1 -receptor in a membrane showing the 7 transmembrane domains. Histamine stimulates the receptor after its penetration into the central core of the receptor. B, A surface view of an activated receptor with histamine linking domains III and V. C, A surface view of an inactive receptor with cetirizine linking domains IV and VI.
FIGURE 1 A, Diagram of a histamine H 1 -receptor in a membrane showing the 7 transmembrane domains. Histamine stimulates the receptor after its penetration into the central core of the receptor. B, A surface view of an activated receptor with histamine linking domains III and V. C, A surface view of an inactive receptor with cetirizine linking domains IV and VI.CC-BY-NC-ND · From the PDF
FIGURE 2 Diagrammatic representation of the absorption of an H 1 -antihistamine. Histamine H 1 -receptors are indicated by stars on the surface of cells and a sensory nerve in the extravascular space.
FIGURE 2 Diagrammatic representation of the absorption of an H 1 -antihistamine. Histamine H 1 -receptors are indicated by stars on the surface of cells and a sensory nerve in the extravascular space.CC-BY-NC-ND · From the PDF
FIGURE 3 Hysteresis loop of the inhibition of the histamine-induced flare response plotted against the plasma concentration of unbound levocetirizine after administration of a single 5-mg dose to children. Redrawn from Ref. 39.
FIGURE 3 Hysteresis loop of the inhibition of the histamine-induced flare response plotted against the plasma concentration of unbound levocetirizine after administration of a single 5-mg dose to children. Redrawn from Ref. 39.CC-BY-NC-ND · From the PDF

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Research works printed but not linked: 68

  1. Windaus, 1907, Synthese des imidazolylathylamins, Ber Dtsch Chem Ges, 3, 3691, 10.1002/cber.190704003164 · DOI
  2. Staub, 1937, Action de la thymoxyethyldiethylamine (929F) et des ethers phenoliques sur le choc anaphylactique, Compt Rend Soc Biol, 125, 818
  3. Halpern, 1942, Les antihistaminiques desynthese. Essais de chemotherapie des etats allergiques, Arch Int Pharmacodyn Ther, 681, 339
  4. Loew, 1946, The antihistamine properties of benadryl, B dimethylaminoethyl benzhydryl ether hydrochloride, J Pharmacol Exp Ther, 86, 229, 10.1016/S0022-3565(25)07849-8 · DOI
  5. Emanuel, 1999, Histamine and the antiallergic antihistamines: a history of their discoveries, Clin Exp Allergy, 29, 1, 10.1046/j.1365-2222.1999.00004.x-i1 · DOI
  6. Leurs, 2001, Histamine receptors are finally 'coming out.', Trends Pharmacol Sci, 22, 337, 10.1016/S0165-6147(00)01691-6 · DOI
  7. Hill, 2006, G-protein-coupled receptors: past, present and future, Br J Pharmacol, 147, S27, 10.1038/sj.bjp.0706455 · DOI
  8. Fukui, 1994, Molecular cloning of the human histamine H1 receptor gene, Biochem Biophys Res Commun, 201, 894, 10.1006/bbrc.1994.1786 · DOI
  9. De Backer, 1998, Structure of the human histamine H1 receptor gene, Biochem J, 335, 663, 10.1042/bj3350663 · DOI
  10. McCudden, 2005, G-protein signaling: back to the future, Cell Mol Life Sci, 62, 551, 10.1007/s00018-004-4462-3 · DOI
  11. Wieland, 1999, Mutational analysis of the antagonist-binding site of the histamine H-1 receptor, J Biol Chem, 274, 29994, 10.1074/jbc.274.42.29994 · DOI
  12. Gillard, 2002, Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194), Mol Pharmacol, 61, 391, 10.1124/mol.61.2.391 · DOI
  13. Leurs, 2002, H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects, Clin Exp Allergy, 32, 489, 10.1046/j.0954-7894.2002.01314.x · DOI
  14. Haas, 2003, The role of histamine and the tuberomamillary nucleus in the nervous system, Nat Rev Neurosci, 4, 121, 10.1038/nrn1034 · DOI · Paper page
  15. Brown, 2001, The physiology of brain histamine, Prog Neurobiol, 63, 637, 10.1016/S0301-0082(00)00039-3 · DOI
  16. Simons, 2004, Advances in H1-antihistamines, N Engl J Med, 351, 2203, 10.1056/NEJMra033121 · DOI
  17. Juniper, 2005, Clinical outcomes and adverse effect monitoring in allergic rhinitis, J Allergy Clin Immunol, 115, S390, 10.1016/j.jaci.2004.12.014 · DOI
  18. Adam, 1986, The hypnotic effects of an antihistamine: promethazine, Br J Clin Pharmacol, 22, 715, 10.1111/j.1365-2125.1986.tb02962.x · DOI
  19. Boyle, 2006, Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects, Curr Med Res Opin, 22, 1343, 10.1185/030079906X112660 · DOI
  20. Rojas-Zamorano, 2009, The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats, Pharmacol Biochem Behav, 91, 291, 10.1016/j.pbb.2008.07.011 · DOI
  21. Kay, 1997, Initial and steady-state effects of diphenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance, Arch Intern Med, 157, 2350, 10.1001/archinte.1997.00440410082009 · DOI
  22. Church, 2010, Should first-generation H1-antihistamines still be available as over-the-counter medications? A GA[2]LEN task force report, Allergy, 65, 459, 10.1111/j.1398-9995.2009.02325.x · DOI · Paper page
  23. Starke, 2005, Boxed warning added to promethazine labeling for pediatric use, N Engl J Med, 352, 2653, 10.1056/NEJM200506233522522 · DOI
  24. Holgate, 2003, Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations, Clin Exp Allergy, 33, 1305, 10.1046/j.1365-2222.2003.01769.x · DOI
  25. Hunt, 2000, Endogenous airway acidification. Implications for asthma pathophysiology, Am J Respir Crit Care Med, 161, 694, 10.1164/ajrccm.161.3.9911005 · DOI
  26. Gillard, 2006, Changes in pH differently affect the binding properties of histamine H1 receptor antagonists, Eur J Pharmacol, 530, 205, 10.1016/j.ejphar.2005.11.051 · DOI
  27. Russell, 1998, Pharmacokinetics, pharmacodynamics, and tolerance of single-and multiple-dose fexofenadine hydrochloride in healthy male volunteers, Clin Pharmacol Ther, 64, 612, 10.1016/S0009-9236(98)90052-2 · DOI
  28. Tannergren, 2003, Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine, Clin Pharmacol Ther, 74, 423, 10.1016/S0009-9236(03)00238-8 · DOI
  29. Gillard, 2005, Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines, Inflamm Res, 54, 367, 10.1007/s00011-005-1368-3 · DOI
  30. Molimard, 2004, Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans, Fundam Clin Pharmacol, 18, 399, 10.1111/j.1472-8206.2004.00254.x · DOI
  31. Popov, 2006, A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo, Inflamm Res, 55, 241, 10.1007/s00011-006-0075-z · DOI
  32. Gillman, 2009, The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines, Allergy Asthma Proc, 30, 366, 10.2500/aap.2009.30.3226 · DOI
  33. Berger, 2006, Efficacy of desloratadine, 5 mg, compared with fexofenadine, 180 mg, in patients with symptomatic seasonal allergic rhinitis, Allergy Asthma Proc, 27, 214, 10.2500/aap.2006.27.2851 · DOI
  34. Bachert, 2009, A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis, Clin Ther, 31, 921, 10.1016/j.clinthera.2009.05.017 · DOI
  35. Potter, 2009, Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients, Allergy, 64, 596, 10.1111/j.1398-9995.2008.01893.x · DOI
  36. Staevska, 2010, The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria, J Allergy Clin Immunol, 125, 676, 10.1016/j.jaci.2009.11.047 · DOI
  37. Simons, 2007, Relevance of H1-receptor occupancy to H1-antihistamine dosing in children, J Allergy Clin Immunol, 119, 1551, 10.1016/j.jaci.2007.02.048 · DOI
  38. Grant, 2002, A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects, Ann Allergy Asthma Immunol, 88, 190, 10.1016/S1081-1206(10)61995-3 · DOI
  39. Purohit, 2003, Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin, Br J Clin Pharmacol, 56, 388, 10.1046/j.1365-2125.2003.01897.x · DOI
  40. Purohit, 2004, Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours, Ann Allergy Asthma Immunol, 92, 635, 10.1016/S1081-1206(10)61429-9 · DOI
  41. Purohit, 2001, Twenty-four hours of activity of cetirizine and fexofenadine in the skin, Ann Allergy Asthma Immunol, 86, 387, 10.1016/S1081-1206(10)62483-0 · DOI
  42. Miura, 2010, Clinical pharmacokinetics of fexofenadine enantiomers, Expert Opin Drug Metab Toxicol, 6, 69, 10.1517/17425250903382615 · DOI
  43. Bakker, 2001, Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling, Mol Pharmacol, 60, 1133, 10.1124/mol.60.5.1133 · DOI
  44. Cheng J, Yang XN, Liu X, Zhang SP: Capsaicin for allergic rhinitis in adults. Cochrane Database Syst Rev. 2006, CD004460-2 · DOI
  45. Canonica, 2008, Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study, Curr Med Res Opin, 24, 2829, 10.1185/03007990802395927 · DOI
  46. Devillier, 2008, Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine: a comparative review, Clin Pharmacokinet, 47, 217, 10.2165/00003088-200847040-00001 · DOI
  47. Schinkel, 1999, P-Glycoprotein, a gatekeeper in the blood-brain barrier, Adv Drug Deliv Rev, 36, 179, 10.1016/S0169-409X(98)00085-4 · DOI
  48. Chen, 2003, P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists, Drug Metab Dispos, 31, 312, 10.1124/dmd.31.3.312 · DOI
  49. Cvetkovic, 1999, OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine, Drug Metab Dispos, 27, 866
  50. Tashiro, 2004, Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography, J Clin Pharmacol, 44, 890, 10.1177/0091270004267590 · DOI
  51. Hindmarch, 2002, An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers, Clin Exp Allergy, 32, 133, 10.1046/j.0022-0477.2001.01245.x · DOI
  52. Tashiro, 2009, Dose dependency of brain histamine H1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [(11)C]doxepin, Hum Psychopharmacol, 24, 540, 10.1002/hup.1051 · DOI
  53. Meltzer, 1996, Comparative outdoor study of the efficacy, onset and duration of action, and safety of cetirizine, loratadine, and placebo for seasonal allergic rhinitis, J Allergy Clin Immunol, 97, 617, 10.1016/S0091-6749(96)70307-X · DOI
  54. Howarth, 1999, Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis, J Allergy Clin Immunol, 104, 927, 10.1016/S0091-6749(99)70070-9 · DOI
  55. Salmun, 2000, Loratadine versus cetirizine: assessment of somnolence and motivation during the workday, Clin Ther, 22, 573, 10.1016/S0149-2918(00)80045-4 · DOI
  56. Mann, 2000, Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice, BMJ, 320, 1184, 10.1136/bmj.320.7243.1184 · DOI · Paper page
  57. De Vos, 2008, Non-interventional study comparing treatment satisfaction in patients treated with antihistamines, Clin Drug Investig, 28, 221, 10.2165/00044011-200828040-00003 · DOI
  58. Day, 2004, Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU), Int J Clin Pract, 58, 109, 10.1111/j.1368-5031.2004.0117.x · DOI · Paper page
  59. Woosley, 1996, Cardiac actions of antihistamines, Annu Rev Pharmacol Toxicol, 36, 233, 10.1146/annurev.pa.36.040196.001313 · DOI
  60. Jo, 2009, H(1) antihistamine drug promethazine directly blocks hERG K(+) channel, Pharmacol Res, 60, 429, 10.1016/j.phrs.2009.05.008 · DOI
  61. Park, 2008, Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656, J Appl Toxicol, 28, 104, 10.1002/jat.1252 · DOI
  62. Zareba, 1997, Electrocardiographic findings in patients with diphenhydramine overdose, Am J Cardiol, 80, 1168, 10.1016/S0002-9149(97)00634-6 · DOI
  63. Ten Eick, 2001, Safety of antihistamines in children, Drug Saf, 24, 119, 10.2165/00002018-200124020-00003 · DOI
  64. DuBuske, 1999, Second-generation antihistamines: the risk of ventricular arrhythmias, Clin Ther, 21, 281, 10.1016/S0149-2918(00)88286-7 · DOI
  65. Simons, 2003, Efficacy and safety of desloratadine in the treatment of perennial allergic rhinitis, J Allergy Clin Immunol, 111, 617, 10.1067/mai.2003.168 · DOI
  66. Hulhoven, 2007, Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study, Eur J Clin Pharmacol, 63, 1011, 10.1007/s00228-007-0366-5 · DOI
  67. Simons, 2002, Comparative pharmacology of H1 antihistamines: clinical relevance, Am J Med, 113, 38S, 10.1016/S0002-9343(02)01436-5 · DOI
  68. Simons, 2002, Clinical pharmacology of H1-antihistamines in the skin, J Allergy Clin Immunol, 110, 777, 10.1067/mai.2002.129123 · DOI

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Metadata

Authors
Church, D. S., & Church, M. K.
Venue
World Allergy Organization Journal
Publisher
Elsevier BV
Published
2011
Volume
4
Pages
S22-S27
ISSN
1939-4551
DOI
10.1186/1939-4551-4-s3-s22
Cited by
57
References
1
Language
en
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Church, D. S., & Church, M. K. (2011). Pharmacology of Antihistamines. World Allergy Organization Journal. https://doi.org/10.1186/1939-4551-4-s3-s22