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The nasal cavity microbiota of healthy adults
Open accessAbstract
BACKGROUND: The microbiota of the nares has been widely studied. However, relatively few studies have investigated the microbiota of the nasal cavity posterior to the nares. This distinct environment has the potential to contain a distinct microbiota and play an important role in health. RESULTS: We obtained 35,142 high-quality bacterial 16S rRNA-encoding gene sequence reads from the nasal cavity and oral cavity (the dorsum of the tongue and the buccal mucosa) of 12 healthy adult humans and deposited these data in the Sequence Read Archive (SRA) of the National Center for Biotechnology Information (NCBI) (Bioproject: PRJNA248297). In our initial analysis, we compared the bacterial communities of the nasal cavity and the oral cavity from ten of these subjects. The nasal cavity bacterial communities were dominated by Actinobacteria, Firmicutes, and Proteobacteria and were statistically distinct from those on the tongue and buccal mucosa. For example, the same Staphylococcaceae operational taxonomic unit (OTU) was present in all of the nasal cavity samples, comprising up to 55% of the community, but Staphylococcaceae was comparatively uncommon in the oral cavity. CONCLUSIONS: There are clear differences between nasal cavity microbiota and oral cavity microbiota in healthy adults. This study expands our knowledge of the nasal cavity microbiota and the relationship between the microbiota of the nasal and oral cavities.
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“In healthy adults, bacteria present in the nasal cavity are typically those associated with skin, predominantly members of the Actinobacteria (e.g., Corynebacterium spp., Propionibacterium spp.), followed by Firmicutes (e.g., Staphylococcus spp.), and Proteobacteria”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [69]
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Metadata
- Authors
- Bassis, C. M., Tang, A. L., Young, V. B., & Pynnonen, M. A.
- Affiliations
- University of Michigan (US)
- University of Cincinnati (US)
- Corresponding author
- Bassis, Christine M
- Venue
- Microbiome
- Published
- 2014-08-11
- Volume
- 2
- Issue
- 1
- Pages
- 27-27
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC4138944
- OpenAlex
- W2161225919
- Cited by
- 209
- References
- 25
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 25 · 2023: 23 · 2022: 22 · 2021: 15 · 2020: 30 · 2019: 14 · 2018: 11 · 2017: 15 · 2016: 13 · 2015: 6
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Microbiome (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- tongue dorsum, buccal mucosa, Staphylococcaceae, bacterial community composition, healthy adults, 16S rRNA gene sequencing, actinobacteria, Firmicutes, Proteobacteria
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