The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Defects in mitochondrial metabolism and cancer
Open accessAbstract
Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to grasp the complexity of cancer by mapping the genetic aberrations associated with it. In these efforts, the contribution of mitochondria to the pathogenesis of cancer has tended to be neglected. However, more recently, a growing body of evidence suggests that mitochondria play a key role in cancer. In fact, dysfunctional mitochondria not only contribute to the metabolic reprogramming of cancer cells but they also modulate a plethora of cellular processes involved in tumorigenesis. In this review, we describe the link between mutations to mitochondrial enzymes and tumor formation. We also discuss the hypothesis that mutations to mitochondrial and nuclear DNA could cooperate to promote the survival of cancer cells in an evolving metabolic landscape.
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Cites
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White, E., Mehnert, J. M., & Chan, C. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0490 · Cited by 664
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Cardaci, S., Zheng, L., MacKay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3233 · Cited by 286
Lussey-Lepoutre, C., Hollinshead, K. E. R., Ludwig, C., Menara, M., Morin, A., Castro-Vega, L.-J., Parker, S. J., Janin, M., Martinelli, C., Ottolenghi, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms9784 · Cited by 227
Mitochondria targeted fluorogenic theranostic agents for cancer therapy
Singh, H., Sareen, D., George, J. M., Bhardwaj, V., Rha, H., Lee, S. J., Sharma, S., Sharma, A., & Kim, J. S. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214283 · Cited by 72
Metadata
- Authors
- Gaude, E., & Frezza, C.
- Venue
- Cancer & Metabolism
- Published
- 2014-07-17
- Volume
- 2
- Issue
- 1
- Pages
- 10-10
- ISSN
- 2049-3002 (ISSN-L)
- OpenAlex
- W2170460043
- Cited by
- 251
- References
- 32
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
