HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

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Functions of S100 Proteins

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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

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The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

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The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

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An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

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IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor <i>in vivo</i>

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Endogenous HMGB1 regulates autophagy

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The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway

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Interleukin-1 (IL-1) Pathway

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Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

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Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

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S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)

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Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

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S100 proteins in cancer

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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

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CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses

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HMGB1: Endogenous Danger Signaling

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Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

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Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

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IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

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The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

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Inflammation and necrosis promote tumour growth

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HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

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IL-33 reduces the development of atherosclerosis

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High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

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IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

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Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

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The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

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Myeloid-related Protein (MRP) 8 and MRP14, Calcium-binding Proteins of the S100 Family, Are Secreted by Activated Monocytes via a Novel, Tubulin-dependent Pathway

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Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation

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The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism

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Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells

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The extracellular release of HMGB1 during apoptotic cell death

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IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

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Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells

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Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

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Secretory autophagy

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IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex

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HMGB1 in Cancer: Good, Bad, or Both?

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