Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia

Martinez-Lavin, Manuel

doi:10.1186/ar2146

Cited by 234Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsHeart Rate Variability and Autonomic Control

Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia

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Martinez-Lavin, Manuel·2007·Arthritis Research & Therapy

DOI 10.1186/ar2146PMC PMC2206360

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Abstract

Stress is a state of disharmony, or threatened homeostasis. A stressor could have a psychological origin or a biological origin. Societies have become more intricate with industrialization, and modern individuals try to adapt to the new defiance by forcing their stress response system. The main component of the stress response network is the autonomic nervous system. The present article reviews current knowledge on autonomic dysfunction in fibromyalgia. Sympathetic hyperactivity has been consistently described by diverse groups of investigators. Fibromyalgia is proposed to be a sympathetically maintained neuropathic pain syndrome, and genomic data support this contention. Autonomic dysfunction may also explain other fibromyalgia features not related to pain.

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The model is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis.
“Third, it is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis [10–17]”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [12]
The Introduction (page unavailable) identifies the HPA axis as a component of the stress-response system and says dysfunction of that system may contribute to fibromyalgia pathogenesis. The paper’s proposal and evidence focus on autonomic dysfunction, however, and our copy does not address a role for the HPG axis. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Both acute stress and chronic stress have been shown to exacerbate the symptoms of fibromyalgia.
“Both acute stress, such as that experienced during traumatic events and chronic stress, such as ongoing conflict or socioeconomic hardships, have been shown to exacerbate the symptoms of fibromyalgia (McEwen 2005; Martinez‐Lavin 2007; Lahat‐Birka et al. 2024).”
From Physical and Mental Health of Fibromyalgia Patients Following October 7th Attack and the Ensuing Military Conflict: A Cross-Sectional Analysis (2025) · cites this paper as Martinez‐Lavin 2007
The section “Fibromyalgia as a sympathetically maintained pain syndrome” reports higher rates of physical or emotional trauma before symptom onset, while the Conclusion proposes a role for stressful lifestyles in fibromyalgia’s development. Neither passage shows that both acute and chronic stress exacerbate symptoms in people who already have fibromyalgia; the claim presents that more specific effect as established. (LLM, conf=0.79)
Experimental — accuracy not yet measured
Fibromyalgia is a stress-related disorder.
“Third, there is evidence that FM is a stress-related disorder [12].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [12]

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Kooh M Martínez-Lavin M Meza S Martín-del-Campo A Hermosillo AG Pineda C Nava A Amigo MC Drucker-Colin R Concurrent heart rate variability and polysomnography analyses in fibromyalgia patients Clin Exp Rheumatol 2003 21 529 530 12942716

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Authors: Martinez-Lavin, M.
Venue: Arthritis Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2007
Volume: 9
Issue: 4
Pages: 216
ISSN: 1478-6354 (ISSN-L)
DOI: 10.1186/ar2146
PMC: PMC2206360
OpenAlex: W2051173145
Cited by: 234
References: 47
Citations by year: 2026: 9 · 2025: 9 · 2024: 14 · 2023: 18 · 2022: 5 · 2021: 17 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 13 · 2012: 12
FWCI: 2.09
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Arthritis Research & Therapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: fibromyalgia, stress, stress system, autonomic dysfunction, sympathetic hyperactivity, sympathetically maintained pain, neuropathic pain, autonomic nervous system, homeostasis
MeSH terms: Fibromyalgia, Homeostasis, Humans, Stress, Physiological, Sympathetic Nervous System

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Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia

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