The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage
Open accessAbstract
NSAIDs are among the most commonly used drugs worldwide and their beneficial therapeutic properties are thoroughly accepted. However, they are also associated with gastrointestinal (GI) adverse events. NSAIDs can damage the whole GI tract including a wide spectrum of lesions. About 1 to 2% of NSAID users experienced a serious GI complication during treatment. The relative risk of upper GI complications among NSAID users depends on the presence of different risk factors, including older age (>65 years), history of complicated peptic ulcer, and concomitant aspirin or anticoagulant use, in addition to the type and dose of NSAID. Some authors recently reported a decreasing trend in hospitalizations due to upper GI complications and a significant increase in those from the lower GI tract, causing the rates of these two types of GI complications to converge. NSAID-induced enteropathy has gained much attention in the last few years and an increasing number of reports have been published on this issue. Current evidence suggests that NSAIDs increase the risk of lower GI bleeding and perforation to a similar extent as that seen in the upper GI tract. Selective cyclooxygenase-2 inhibitors have the same beneficial effects as nonselective NSAIDs but with less GI toxicity in the upper GI tract and probably in the lower GI tract. Overall, mortality due to these complications has also decreased, but the in-hospital case fatality for upper and lower GI complication events has remained constant despite the new therapeutic and prevention strategies.
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Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis
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Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs
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Schnitzer, T. J., Burmester, G. R., Mysler, E., Hochberg, M. C., Doherty, M., Ehrsam, E., Gitton, X., Krammer, G., Mellein, B., Matchaba, P., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16893-1 · Cited by 701
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Self-citationGoldstein, J. L., Eisen, G. M., Lewis, B., Gralnek, I. M., Zlotnick, S., & Fort, J. G. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00619-6 · Cited by 659
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Self-citationChan, F. K. L., Hung, L. C. T., Suen, B. Y., Wu, J. C. Y., Lee, K. C., Leung, V. K. S., Hui, A. J., To, K. F., Leung, W. K., Wong, V. W. S., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021907 · Cited by 555
Cited by
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
Bindu, S., Mazumder, S., & Bandyopadhyay, U. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114147 · Cited by 1,920
for the SIF-AIGO-FIMMG Group, Scarpignato, C., on behalf of the Italian Society of Pharmacology, T. I. A. O. H. G., Gatta, L., Zullo, A., & Blandizzi, C. (2016) · BMC Medicine · doi:10.1186/s12916-016-0718-z · Cited by 469
Gwee, K.-A., Goh, V., Lima, G., & Setia, S. (2018) · Journal of Pain Research · doi:10.2147/jpr.s156938 · Cited by 117
Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis
Bannuru, R. R., Osani, M. C., Al-Eid, F., & Wang, C. (2018) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2018.03.001 · Cited by 110
Marlicz, W., Łoniewski, I., Grimes, D. S., & Quigley, E. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.015 · Cited by 91
Metadata
- Authors
- Sostres, C., Gargallo, C. J., & Lanas, A.
- Venue
- Arthritis Research & Therapy
- Published
- 2013
- Volume
- 15
- Issue
- Suppl 3
- Pages
- S3
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W2097111776
- Cited by
- 406
- References
- 49
- Type
- conference abstract
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
