The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
Open accessAbstract
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family are known to exist. Based on substrate specificity and domain organization, the MMPs can be loosely divided into four main groups: the interstitial collagenases, gelatinases, stromelysins and membrane-type MMPs. Recent data from model systems suggest that MMPs are involved in breast cancer initiation, invasion and metastasis. Consistent with their role in breast cancer progression, high levels of at least two MMPs (MMP-2 and stromelysin-3) have been found to correlate with poor prognosis in patients with breast cancer. Because MMPs are apparently involved in breast cancer initiation and dissemination, inhibition of these proteinases may be of value both in preventing breast cancer and in blocking metastasis of established tumours
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Ohuchi, E., Imai, K., Fujii, Y., Sato, H., Seiki, M., & Okada, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2446 · Cited by 938
Baker, A. H., George, S. J., Zaltsman, A. B., Murphy, G., & Newby, A. C. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690217 · Cited by 286
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Liou, G.-Y., & Storz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,382
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Sansone, P., Storci, G., Tavolari, S., Guarnieri, T., Giovannini, C., Taffurelli, M., Ceccarelli, C., Santini, D., Paterini, P., Marcu, K. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32533 · Cited by 779
Metadata
- Authors
- Duffy, M. J., Maguire, T. M., Hill, A., McDermott, E., & O'Higgins, N.
- Venue
- Breast Cancer Research
- Published
- 2000-08
- Volume
- 2
- Issue
- 4
- Pages
- 252-7
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- OpenAlex
- W1605046409
- Cited by
- 628
- References
- 2
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Duffy, M. J., Maguire, T. M., Hill, A., McDermott, E., & O'Higgins, N. (2000). Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Research. https://doi.org/10.1186/bcr65
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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