The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
Open accessAbstract
Introduction: Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with fresh frozen plasma (FFP)-based haemostatic therapy. Methods: This retrospective analysis compared patients from the Salzburg Trauma Centre (Salzburg, Austria) treated with fibrinogen concentrate and/or PCC, but no FFP (fibrinogen-PCC group, n = 80), and patients from the TraumaRegister DGU receiving ≥ 2 units of FFP, but no fibrinogen concentrate/PCC (FFP group, n = 601). Inclusion criteria were: age 18-70 years, base deficit at admission ≥2 mmol/L, injury severity score (ISS) ≥16, abbreviated injury scale for thorax and/or abdomen and/or extremity ≥3, and for head/neck < 5. Results: For haemostatic therapy in the emergency room and during surgery, the FFP group (ISS 35.5 ± 10.5) received a median of 6 units of FFP (range: 2, 51), while the fibrinogen-PCC group (ISS 35.2 ± 12.5) received medians of 6 g of fibrinogen concentrate (range: 0, 15) and 1200 U of PCC (range: 0, 6600). RBC transfusion was avoided in 29% of patients in the fibrinogen-PCC group compared with only 3% in the FFP group (P< 0.001). Transfusion of platelet concentrate was avoided in 91% of patients in the fibrinogen-PCC group, compared with 56% in the FFP group (P< 0.001). Mortality was comparable between groups: 7.5% in the fibrinogen-PCC group and 10.0% in the FFP group (P = 0.69). Conclusions: TEM-guided haemostatic therapy with fibrinogen concentrate and PCC reduced the exposure of trauma patients to allogeneic blood products.
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Cites
Brohi, K., Singh, J., Heron, M., & Coats, T. (2003) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000069184.82147.06 · Cited by 1,726
Borgman, M. A., Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Repine, T., Beekley, A. C., Sebesta, J., Jenkins, D., Wade, C. E., & Holcomb, J. B. (2007) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e3181271ba3 · Cited by 1,582
Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma
Holcomb, J. B., Jenkins, D., Rhee, P., Johannigman, J., Mahoney, P., Mehta, S., Cox, E. D., Gehrke, M. J., Beilman, G. J., Schreiber, M., et al. (2007) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e3180324124 · Cited by 1,370
Management of bleeding following major trauma: an updated European guideline
Rossaint, R., Bouillon, B., Cerny, V., Coats, T. J., Duranteau, J., Fernández-Mondéjar, E., Hunt, B. J., Komadina, R., Nardi, G., Neugebauer, E., et al. (2010) · Critical Care · doi:10.1186/cc8943 · Cited by 818
Activity‐based costs of blood transfusions in surgical patients at four hospitals
Shander, A., Hofmann, A., Ozawa, S., Theusinger, O. M., Gombotz, H., & Spahn, D. R. (2010) · Transfusion · doi:10.1111/j.1537-2995.2009.02518.x · Cited by 747
Schöchl, H., Nienaber, U., Hofer, G., Voelckel, W., Jambor, C., Scharbert, G., Kozek-Langenecker, S., & Solomon, C. (2010) · Critical Care · doi:10.1186/cc8948 · Cited by 637
Self-citationFresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion
Gonzalez, E. A., Moore, F. A., Holcomb, J. B., Miller, C. C., Kozar, R. A., Todd, S. R., Cocanour, C. S., Balldin, B. C., & McKinley, B. A. (2007) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000250497.08101.8b · Cited by 568
Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography
RUGERI, L., LEVRAT, A., DAVID, J. S., DELECROIX, E., FLOCCARD, B., GROS, A., ALLAOUCHICHE, B., & NEGRIER, C. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02319.x · Cited by 491
Platelet receptors and signaling in the dynamics of thrombus formation
Rivera, J., Lozano, M. L., Navarro-Nunez, L., & Vicente, V. (2009) · Haematologica · doi:10.3324/haematol.2008.003178 · Cited by 416
Stinger, H. K., Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Salinas, J., Martini, W. Z., Hess, J. R., Dubick, M. A., Simon, C. D., Beekley, A. C., et al. (2008) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e318160a57b · Cited by 414
Cited by
Haas, T., Fries, D., Tanaka, K. A., Asmis, L., Curry, N. S., & Schöchl, H. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aeu303 · Cited by 249
Self-citationMallaiah, S., Barclay, P., Harrod, I., Chevannes, C., & Bhalla, A. (2015) · Anaesthesia · doi:10.1111/anae.12859 · Cited by 213
Walsh, M., Fritz, S., Hake, D., Son, M., Greve, S., Jbara, M., Chitta, S., Fritz, B., Miller, A., K Bader, M., et al. (2016) · Current Drug Targets · doi:10.2174/1389450117666160310153211 · Cited by 58
Metadata
- Authors
- Schöchl, H., Nienaber, U., Maegele, M., Hochleitner, G., Primavesi, F., Steitz, B., Arndt, C., Hanke, A., Voelckel, W., & Solomon, C.
- Venue
- Critical Care
- Published
- 2011-03-04
- Volume
- 15
- Issue
- 2
- Pages
- R83-R83
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2028679380
- Cited by
- 398
- References
- 37
- FWCI
- 29.97
- Type
- journal article
- Language
- en
- Open access
- gold
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