The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
Open accessAbstract
Introduction: Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain. Methods: We used medical chart reviews to collect data on ICU adult patients reported in a standardized form. Influenza A (H1N1)v infection was confirmed in specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR) assay. Results: Illness onset of the 32 patients occurred between 23 June and 31 July, 2009. The median age was 36 years (IQR = 31 - 52). Ten (31.2%) were obese, 2 (6.3%) pregnant and 16 (50%) had pre-existing medical complications. Twenty-nine (90.6%) had primary viral pneumonitis, 2 (6.3%) exacerbation of structural respiratory disease and 1 (3.1%) secondary bacterial pneumonia. Twenty-four patients (75.0%) developed multiorgan dysfunction, 7 (21.9%) received renal replacement techniques and 24 (75.0%) required mechanical ventilation. Six patients died within 28 days, with two additional late deaths. Oseltamivir administration delay ranged from 2 to 8 days after illness onset, 31.2% received high-dose (300 mg/day), and treatment duration ranged from 5 to 10 days (mean 8.0 ± 3.3). Conclusions: Over a 5-week period, influenza A (H1N1)v infection led to ICU admission in 32 adult patients, with frequently observed severe hypoxemia and a relatively high case-fatality rate. Clinicians should be aware of pulmonary complications of influenza A (H1N1)v infection, particularly in pregnant and young obese but previously healthy persons.
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Cites
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325
Harper, S. A., Bradley, J. S., Englund, J. A., File, T. M., Gravenstein, S., Hayden, F. G., McGeer, A. J., Neuzil, K. M., Pavia, A. T., Tapper, M. L., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/598513 · Cited by 647
Cited by
Rice, T. W., Rubinson, L., Uyeki, T. M., Vaughn, F. L., John, B. B., Miller, R. R., Higgs, E., Randolph, A. G., Smoot, B. E., & Thompson, B. T. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182416f23 · Cited by 391
Bacterial Coinfection in Influenza: A Grand Rounds Review
Chertow, D. S., & Memoli, M. J. (2013) · JAMA · doi:10.1001/jama.2012.194139 · Cited by 390
MacIntyre, C. R., Chughtai, A. A., Barnes, M., Ridda, I., Seale, H., Toms, R., & Heywood, A. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3548-0 · Cited by 323
Pandemic 2009 Influenza A in Argentina: A Study of 337 Patients on Mechanical Ventilation
Estenssoro, E., Ríos, F. G., Apezteguía, C., Reina, R., Neira, J., Ceraso, D. H., Orlandi, C., Valentini, R., Tiribelli, N., Brizuela, M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/201001-0037oc · Cited by 230
Martín-Loeches, I., Sanchez-Corral, A., Diaz, E., Granada, R. M., Zaragoza, R., Villavicencio, C., Albaya, A., Cerdá, E., Catalán, R. M., Luque, P., et al. (2011) · Chest · doi:10.1378/chest.10-1396 · Cited by 203
Self-citationFatalities Associated with the 2009 H1N1 Influenza A Virus in New York City
Lee, E. H., Wu, C., Lee, E. U., Stoute, A., Hanson, H., Cook, H. A., Nivin, B., Fine, A. D., Kerker, B. D., Harper, S. A., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/652446 · Cited by 126
Cui, W., Zhao, H., Lu, X., Wen, Y., Zhou, Y., Deng, B., Wang, Y., Wang, W., Kang, J., & Liu, P. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-145 · Cited by 98
Muscedere, J., Ofner, M., Kumar, A., Long, J., Lamontagne, F., Cook, D., McGeer, A., Chant, C., Marshall, J., Jouvet, P., et al. (2013) · Chest · doi:10.1378/chest.12-1861 · Cited by 40
Metadata
- Authors
- Rello, J., Rodríguez, A., Ibañez, P., Socias, L., Cebrian, J., Marques, A., Guerrero, J., Ruiz-Santana, S., Marquez, E., Del Nogal-Saez, F., Alvarez-Lerma, F., Martínez, S., Ferrer, M., Avellanas, M., Granada, R., Maraví-Poma, E., Albert, P., Sierra, R., Vidaur, L., Ortiz, P., Prieto del Portillo, I., Galván, B., León-Gil, C., & the H1N1 SEMICYUC working group
- Venue
- Critical Care
- Published
- 2009-09-11
- Volume
- 13
- Issue
- 5
- Pages
- R148-R148
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2097837491
- Cited by
- 446
- References
- 3
- FWCI
- 58.81
- Type
- journal article
- Language
- en
- Open access
- gold
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