Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis
Open accessAbstract
Introduction: Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects the microvasculature, yet the relationships between RAS and organ injury in clinical sepsis remain unclear. We tested our hypothesis that systemic RAS mediators are associated with dysregulation of the microvasculature and with organ failure in clinical severe sepsis. Methods: We studied 30 subjects with severe sepsis, and 10 healthy control subjects. Plasma was analyzed for plasma renin activity (PRA) and angiotensin II concentration (Ang II). Using near-infrared spectroscopy, we measured the rate of increase in the oxygen saturation of thenar microvascular hemoglobin after five minutes of induced forearm ischemia. In so doing, we assessed bulk microvascular hemoglobin influx to the tissue during reactive hyperemia. We studied all subjects 24 hours after the development of organ failure. We studied a subset of 12 subjects at an additional timepoint, eight hours after recognition of organ failure (early sepsis). Results: After 24 hours of resuscitation to clinically-defined endpoints of preload and arterial pressure, Ang II and PRA were elevated in septic subjects and the degree of elevation correlated negatively with the rate of microvascular reoxygenation during reactive hyperemia. Early RAS mediators correlated with microvascular dysfunction. Early Ang II also correlated with the extent of organ failure realized during the first day of sepsis. Conclusions: RAS is activated in clinical severe sepsis. Systemic RAS mediators correlate with measures of microvascular dysregulation and with organ failure.
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Patients with sepsis demonstrate increased activity of the RAAS.
“Patients with sepsis demonstrate increased activity of the RAAS [143].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [143]
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Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743 · see citing works
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun‐Buisson, C., Beale, R. J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,722 · see citing works
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E. H., Angus, D. C., Cook, D., Cohen, J., Opal, S. M., Vincent, J., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,976 · see citing works
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference
(1992) · Critical Care Medicine · doi:10.1097/00003246-199206000-00025 · Cited by 5,091 · see citing works
Vincent, J.-L., de Mendonca, A., Cantraine, F., Moreno, R., Takala, J., Suter, P. M., Sprung, C. L., Colardyn, F., & Blecher, S. (1998) · Critical Care Medicine · doi:10.1097/00003246-199811000-00016 · Cited by 3,463 · see citing works
Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
Ferreira, F. L. (2001) · JAMA · doi:10.1001/jama.286.14.1754 · Cited by 2,862 · see citing works
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453 · see citing works
Microvascular Blood Flow Is Altered in Patients with Sepsis
Backer, D. D., Créteur, J., Preiser, J., Dubois, M., & Vincent, J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200109-016oc · Cited by 1,462 · see citing works
Sakr, Y. L., Dubois, M., Backer, D. D., Créteur, J., & Vincent, J. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000138558.16257.3f · Cited by 1,254 · see citing works
Pulmonary-Artery versus Central Venous Catheter to Guide Treatment of Acute Lung Injury
The National Heart, L. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061895 · Cited by 976 · see citing works
Validation of near-infrared spectroscopy in humans
Mancini, D. M., Bolinger, L., Li, H., Kendrick, K., Chance, B., & Wilson, J. R. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.6.2740 · Cited by 669 · see citing works
Nitroglycerin in septic shock after intravascular volume resuscitation
Spronk, P. E., İnce, C., Gardien, M., Mathura, K. R., Straaten, H. M. O., & Zandstra, D. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11393-6 · Cited by 541 · see citing works
Dubín, A., Pozo, M. O., Casabella, C. A., Pálizas, F., Murias, G. E., Moseinco, M. C., Edul, V. S. K., Pálizas, F., Estenssoro, E., & İnce, C. (2009) · Critical Care · doi:10.1186/cc7922 · Cited by 467 · see citing works
The prognostic value of muscle StO2 in septic patients
Créteur, J., Carollo, T., Soldati, G., Büchele, G. L., Backer, D. D., & Vincent, J. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0739-3 · Cited by 351 · see citing works
Near‐infrared spectroscopy for monitoring muscle oxygenation
Boushel, R., & Piantadosi, C. A. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00713.x · Cited by 300 · see citing works
Effect of a maldistribution of microvascular blood flow on capillary O2 extraction in sepsis
Ellis, C. G., Bateman, R. M., Sharpe, M. D., Sibbald, W. J., & Gill, R. S. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2002.282.1.h156 · Cited by 277 · see citing works
Jhanji, S., Stirling, S., Patel, N. G., Hinds, C., & Pearse, R. M. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a00a1c · Cited by 252 · see citing works
Pastore, L., Tessitore, A., Martinotti, S., Toniato, E., Alesse, E., Bravi, M. C., Ferri, C., Desideri, G., Gulino, A., & Santucci, A. (1999) · Circulation · doi:10.1161/01.cir.100.15.1646 · Cited by 249 · see citing works
Impairments in microvascular reactivity are related to organ failure in human sepsis
Doerschug, K. C., Delsing, A. S., Schmidt, G. A., & Haynes, W. G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01237.2006 · Cited by 242 · see citing works
Self-citationHeenen, S., Backer, D. D., & Vincent, J. (2006) · Critical Care · doi:10.1186/cc4970 · Cited by 197 · see citing works
Myers, D. E., Anderson, L. D., Seifert, R. P., Ortner, J. P., Cooper, C. E., Beilman, G. J., & Mowlem, J. D. (2005) · Journal of Biomedical Optics · doi:10.1117/1.1925250 · Cited by 187 · see citing works
Direct evidence of leukocyte adhesion in arterioles by angiotensin II
Álvarez, Á., Cerdá‐Nicolás, M., Nabah, Y. N. A., Mata, M., Issekutz, A. C., Panés, J., Lobb, R. R., & Sanz, M. (2004) · Blood · doi:10.1182/blood-2003-08-2974 · Cited by 180 · see citing works
DYNAMIC NEAR-INFRARED SPECTROSCOPY MEASUREMENTS IN PATIENTS WITH SEVERE SEPSIS
Skarda, D. E., Mulier, K. E., Myers, D. E., Taylor, J. H., & Beilman, G. J. (2007) · Shock · doi:10.1097/01.shk.0000239779.25775.e4 · Cited by 179 · see citing works
Fluid Therapy in Resuscitated Sepsis
Durairaj, L., & Schmidt, G. A. (2008) · CHEST Journal · doi:10.1378/chest.07-1496 · Cited by 150 · see citing works
Self-citationBlasi, R. A. D., Palmisani, S., Alampi, D., Mercieri, M., Romano, R., Collini, S., & Pinto, G. (2005) · Intensive Care Medicine · doi:10.1007/s00134-005-2822-y · Cited by 138 · see citing works
Wheeler, A. P., Thompson, B., Schoenfeld, D., Wiede, H. P., & deBoisblanc, B. (2006) · Cited by 129 · see citing works
Mateo, T., Nabah, Y. N. A., Abu-Taha, M. I., Mata, M., Cerdá‐Nicolás, M., Proudfoot, A. E. I., Stahl, R. A. K., Issekutz, A. C., Cortijo, J., Morcillo, E. J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5577 · Cited by 98 · see citing works
Gómez, H., Mesquida, J., Simon, P., Kim, H. K., Puyana, J. C., Ince, C., & Pinsky, M. R. (2009) · Critical Care · doi:10.1186/cc8001 · Cited by 94 · see citing works
Microvascular resuscitation as a therapeutic goal in severe sepsis.
Bateman, R. M., & Walley, K. R. (2005) · Critical Care · doi:10.1186/cc3756 · Cited by 76 · see citing works
Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis
Tyml, K., Yu, J., & McCormack, D. G. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.3.837 · Cited by 71 · see citing works
Higashi, Y., Sasaki, S., Nakagawa, K., Matsuura, H., Kajiyama, G., & Oshima, T. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01177-3 · Cited by 68 · see citing works
Comparison of buccal microcirculation between septic and hemorrhagic shock
Fang, X., Tang, W., Sun, S., Huang, L., Chang, Y.-T., Castillo, C., & Weil, M. H. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000246011.86907.3a · Cited by 65 · see citing works
Bechara, R. I., Peláez, A., Palacio, A., Joshi, P. C., Hart, C. M., Brown, L. A. S., Raynor, R. L., & Guidot, D. M. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00141.2005 · Cited by 63 · see citing works
Effect of Angiotensin II on Microvascular Permeability
Victorino, G. P., Newton, C. R., & Curran, B. C. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6412 · Cited by 59 · see citing works
Peripheral Vascular Tone in Sepsis
Astiz, M. E., Tilly, E., Rackow, E. C., & Weil, M. H. (1991) · CHEST Journal · doi:10.1378/chest.99.5.1072 · Cited by 53 · see citing works
Tadros, T., Traber, D. L., Heggers, J. P., & Herndon, D. N. (2000) · Annals of Surgery · doi:10.1097/00000658-200004000-00017 · Cited by 49 · see citing works
Role of angiotensin II in endothelial dysfunction induced by lipopolysaccharide in mice
Lund, D. D., Brooks, R. M., Faraci, F. M., & Heistad, D. D. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01116.2007 · Cited by 48 · see citing works
Boldt, J., Papsdorf, M., Kumle, B., Piper, S., & Hempelmann, G. (1998) · Critical Care Medicine · doi:10.1097/00003246-199810000-00018 · Cited by 47 · see citing works
ENALAPRILAT IMPROVES GUT PERFUSION IN CRITICALLY INJURED PATIENTS
Kincaid, E. H., Miller, P. R., Meredith, J. W., & Chang, M. (1998) · Shock · doi:10.1097/00024382-199802000-00001 · Cited by 42 · see citing works
Renin-Angiotensin System in Sepsis
Hilgenfeldt, U., Kienapfel, G., Kellermann, W., Schott, R., & Schmidt, M. (1987) · Clinical and Experimental Hypertension · doi:10.3109/10641968709158998 · Cited by 41 · see citing works
Oldner, A., Wanecek, M., Weitzberg, E., Rundgren, M., Alving, K., Ullman, J., & Rudehill, A. (1999) · Shock · doi:10.1097/00024382-199902000-00010 · Cited by 22 · see citing works
Vascular responses to norepinephrine, angiotensin, vasopressin and serotonin.
Abboud, F. M. (1969) · PubMed · Cited by 22 · see citing works
Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives
Murphey, L. J., Morrow, J. D., Sawathiparnich, P., Williams, G. H., Vaughan, D. E., & Brown, N. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00395-2 · Cited by 21 · see citing works
Itoh, T., Kajikuri, J., Tada, T., Suzuki, Y., & Mabuchi, Y. (2003) · The Journal of Physiology · doi:10.1111/j..2003.t01-1-00893.x · Cited by 21 · see citing works
Itoh, T., Kajikuri, J., Tada, T., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034116 · Cited by 16 · see citing works
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun-Buisson, C., Beale, R., et al. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0000298158.12101.41 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Khan, A., Benthin, C., Zeno, B. R., Albertson, T. E., Boyd, J. H., Christie, J. D., Hall, R., Poirier, G., Ronco, J. J., Tidswell, M., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1823-x · Cited by 600 · see citing works
Cognitive impact of COVID-19: looking beyond the short term
Miners, J. S., Kehoe, P. G., & Love, S. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00744-w · Cited by 248 · see citing works
Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System
Brojakowska, A., Narula, J., Shimony, R. Y., & Bander, J. A. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.04.028 · Cited by 156 · see citing works
Ronco, C., & Lullo, L. D. (2014) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.12.003 · Cited by 126 · see citing works
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“Furthermore, the SNS is the important stimulator of the renin-angiotensin-aldosterone system (RAAS) leading to water and sodium retention (see below).”
BackgroundInfluentialRenin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients*
Gleeson, P. J., Crippa, I. A., Mongkolpun, W., Cavicchi, F. Z., Meerhaeghe, T. V., Brimioulle, S., Taccone, F. S., Vincent, J., & Créteur, J. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003544 · Cited by 106 · see citing works
Angiotensin II in septic shock
Corrêa, T. D., Takala, J. A., & Jakob, S. M. (2015) · Critical Care · doi:10.1186/s13054-015-0802-3 · Cited by 105 · see citing works
Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill
Bitker, L., & Burrell, L. M. (2019) · Critical Care Clinics · doi:10.1016/j.ccc.2018.11.002 · Cited by 101 · see citing works
Renin–Angiotensin–Aldosterone System and Immunomodulation: A State-of-the-Art Review
Laghlam, D., Jozwiak, M., & Nguyen, L. S. (2021) · Cells · doi:10.3390/cells10071767 · Cited by 96 · see citing works
Drenger, B., Fontes, M. L., Miao, Y., Mathew, J. P., Gozal, Y., Aronson, S., Dietzel, C., & Mangano, D. T. (2012) · Circulation · doi:10.1161/circulationaha.111.059527 · Cited by 85 · see citing works
Zheng, H., & Cao, J. J. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.07.009 · Cited by 79 · see citing works
Angiotensin II in Septic Shock
Corrêa, T. D., Jeger, V., Pereira, A. J., Takala, J. A., Djafarzadeh, S., & Jakob, S. M. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000397 · Cited by 79 · see citing works
Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury
Leisman, D. E., Fernandes, T., Bijol, V., Abraham, M. N., Lehman, J. R., Taylor, M. D., Capone, C., Yaipan, O. Y., Bellomo, R., & Deutschman, C. S. (2020) · Kidney International · doi:10.1016/j.kint.2020.07.047 · Cited by 69 · see citing works
Wang, D., Chai, X., Magnussen, C. G., Zosky, G. R., Shu, S., Wei, X., & Hu, S. (2019) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2019.101833 · Cited by 65 · see citing works
Neto, A. S., Pereira, V. G. M., Manetta, J. A., Espósito, D. C., & Schultz, M. J. (2013) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3182a9221f · Cited by 65 · see citing works
Florescu, S. A., Stanciu, D., Zaharia, M. F., Kosa, A. G., Codreanu, D. R., Fareed, K., Kidwai, A., Kaye, C. T., Coutts, A., MacKay, L., et al. (2023) · JAMA · doi:10.1001/jama.2023.4480 · Cited by 64 · see citing works
Angiotensin II in Refractory Septic Shock
Antonucci, E., Gleeson, P. J., Annoni, F., Agosta, S., Orlando, S., Taccone, F. S., Velissaris, D., & Scolletta, S. (2016) · Shock · doi:10.1097/shk.0000000000000807 · Cited by 64 · see citing works
Beta‐Adrenergic Blockers as a Potential Treatment for COVID‐19 Patients
Vasanthakumar, N. (2020) · BioEssays · doi:10.1002/bies.202000094 · Cited by 63 · see citing works
Chen, X.-S., Cui, J.-R., Meng, X.-L., Wang, S., Wei, W., Gao, Y., Shou, S., Liu, Y., & Chai, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-022-03842-5 · Cited by 61 · see citing works
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis*
Lankadeva, Y. R., Booth, L. C., Kosaka, J., Evans, R. G., Quintin, L., Bellomo, R., & May, C. N. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000963 · Cited by 58 · see citing works
Öz, M., & Lorke, D. E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111193 · Cited by 55 · see citing works
Flannery, A. H., Ortiz-Soriano, V., Li, X., Gianella, F. G., Toto, R. D., Moe, O. W., Devarajan, P., Goldstein, S. L., & Neyra, J. A. (2021) · Critical Care · doi:10.1186/s13054-021-03725-z · Cited by 55 · see citing works
Vasopressor Therapy and Blood Pressure Management in the Setting of Acute Kidney Injury
Busse, L. W., & Ostermann, M. (2019) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2019.06.006 · Cited by 52 · see citing works
Mehta, R. L., Rabb, H., Shaw, A., Singbartl, K., Ronco, C., McCullough, P. A., Kellum, J. A., & for the Acute Dialysis Quality Initiative (ADQI) 11 Working Group (2013) · Contributions to nephrology · doi:10.1159/000349970 · Cited by 52 · see citing works
Nakada, T., Russell, J. A., Boyd, J. H., McLaughlin, L., Nakada, E., Thair, S. A., Hirasawa, H., Oda, S., & Walley, K. R. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318218665a · Cited by 51 · see citing works
Forebrain control of breathing: Anatomy and potential functions
Schottelkotte, K. M., & Crone, S. A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1041887 · Cited by 48 · see citing works
Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis
Tsai, H.-J., Liao, M., Shih, C.-C., Ka, S., Tsao, C., & Wu, C.-C. (2018) · Critical Care · doi:10.1186/s13054-018-2210-y · Cited by 47 · see citing works
Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019
Camargo, R. L., Bombassaro, B., Monfort‐Pires, M., Mansour, E., Palma, A. C., Ribeiro, L. C., Ulaf, R. G., Bernardes, A. F., Nunes, T. A., de Agrela, M. V. R., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.847809 · Cited by 46 · see citing works
Hsieh, M., How, C., Hsieh, V. C., & Chen, P. (2019) · Shock · doi:10.1097/shk.0000000000001382 · Cited by 45 · see citing works
Antihypertensive agents acting on the renin–angiotensin system and the risk of sepsis
Dial, S., Nessim, S. J., Kezouh, A., Benisty, J. I., & Suissa, S. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12419 · Cited by 44 · see citing works
Dembek, K. A., Onasch, K., Hurcombe, S. D. A., MacGillivray, K., Slovis, N. M., Barr, B. S., Reed, S. M., & Toribio, R. E. (2013) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12043 · Cited by 44 · see citing works
Nguyen, M., Denimal, D., Dargent, A., Guinot, P., Duvillard, L., Quenot, J., & Bouhemad, B. (2018) · Shock · doi:10.1097/shk.0000000000001285 · Cited by 41 · see citing works
Kasal, D. A. B., Lorenzo, A. D., & Tibiriçá, E. V. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.08.010 · Cited by 41 · see citing works
D’Elia, J. A., & Weinrauch, L. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092465 · Cited by 39 · see citing works
Angiotensin II in septic shock
Jadhav, A. P., & Sadaka, F. G. (2019) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2019.03.026 · Cited by 39 · see citing works
Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications
Ning, L., Rong, J., Zhang, Z., & Xu, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105409 · Cited by 36 · see citing works
Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone
Proczka, M. S., Przybylski, J., Cudnoch‐Jędrzejewska, A., Szczepanska‐Sadowska, E. K., & Żera, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.744177 · Cited by 34 · see citing works
Year in review 2010: Critical Care - multiple organ dysfunction and sepsis
de Montmollin, É., & Annane, D. (2011) · Critical Care · doi:10.1186/cc10359 · Cited by 34 · see citing works
Cheng, X., Tong, J., Hu, Q., Chen, S., Yin, Y., & Liu, Z. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu330 · Cited by 34 · see citing works
Angiotensin II: a new therapeutic option for vasodilatory shock
Bussard, R. L., & Busse, L. W. (2018) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s150434 · Cited by 34 · see citing works
Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19
Aladağ, E., Taş, Z., Ozdemir, B. S., Akbaba, T. H., Akpınar, M. G., Göker, H., Ünalan-Altıntop, T., İnkaya, A. Ç., Alp, A., Metan, G., et al. (2021) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2021/5509280 · Cited by 33 · see citing works
Senatore, F. F., Balakumar, P., & Jagadeesh, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105916 · Cited by 29 · see citing works
Razeghian‐Jahromi, I., Zibaeenezhad, M. J., Lu, Z., Elyaspour, Z., Razmkhah, M., & Lionetti, V. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-10016-2 · Cited by 28 · see citing works
Chung, K. S., Song, J. H., Jung, W. J., Kim, Y. S., Kim, S. I., Chang, J., & Park, M. S. (2017) · The Korean Journal of Critical Care Medicine · doi:10.4266/kjccm.2017.00094 · Cited by 28 · see citing works
Lee, H. W., Suh, J. K., Jang, E.-J., & Lee, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2019.262 · Cited by 26 · see citing works
Leśnik, P., Łysenko, L., Krzystek‐Korpacka, M., Woźnica-Niesobska, E., Mierzchała-Pasierb, M., & Janc, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169133 · Cited by 26 · see citing works
R1 autonomic nervous system in acute kidney injury
Hering, D., & Winklewski, P. J. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12694 · Cited by 24 · see citing works
Angiotensin II receptor type 1 blockade improves hyporesponsiveness to vasopressors in septic shock
Fernandes, D., Pacheco, L. K., Sordi, R., Scheschowitsch, K., Ramos, G. C., & Assreuy, J. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173953 · Cited by 23 · see citing works
Pulmonary midkine inhibition ameliorates sepsis induced lung injury
Xu, J., Chang, W., Sun, Q., Peng, F., & Yang, Y. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02755-z · Cited by 22 · see citing works
Genetic Susceptibility to Non-Necrotizing Erysipelas/Cellulitis
Hannula‐Jouppi, K., Massinen, S., Siljander, T., Mäkelä, S., Kivinen, K., Leinonen, R., Jiao, H., Aitos, P., Karppelin, M., Vuopio, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056225 · Cited by 22 · see citing works
Mechanisms of Post-critical Illness Cardiovascular Disease
Owen, A., Patel, J. M., Parekh, D., & Bangash, M. N. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.854421 · Cited by 21 · see citing works
Xu, D., Liu, Y., Mao, Y., Wang, Y., Xu, C., Zhu, X., & Jiang, L. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16382 · Cited by 19 · see citing works
Julien, C., Oréa, V., Quintin, L., Piriou, V., & Barrès, C. (2017) · Physiological Reports · doi:10.14814/phy2.13139 · Cited by 18 · see citing works
Wu, C., Chen, Y., Zhou, P., & Hu, Z. (2023) · Annals of Translational Medicine · doi:10.21037/atm-22-6016 · Cited by 17 · see citing works
Wang, J., Li, J., Lou, A., Lin, Y. H., Xu, Q., Cui, W., Huang, W., Wang, G., Li, Y., Sun, J., et al. (2022) · FEBS Journal · doi:10.1111/febs.16696 · Cited by 16 · see citing works
A primitive type of renin-expressing lymphocyte protects the organism against infections
Belyea, B., Santiago, A. E., Vasconez, W. A., Nagalakshmi, V. K., Xu, F. L., Mehalic, T. C., Sequeira-Lόpez, M. L. S., & Gómez, R. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-86629-w · Cited by 16 · see citing works
Correlations between ACE single nucleotide polymorphisms and prognosis of patients with septic shock
Dou, X., Cheng, H., Meng, L., Zhou, L., Ke, Y.-H., Liu, L., & Li, Y. (2017) · Bioscience Reports · doi:10.1042/bsr20170145 · Cited by 15 · see citing works
Zhang, G., & Zhang, K. (2024) · Inflammation · doi:10.1007/s10753-024-02059-6 · Cited by 13 · see citing works
Acute toll‐like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour
Beusecum, J. P. V., Zhang, S., Cook, A. K., & Inscho, E. W. (2017) · Acta Physiologica · doi:10.1111/apha.12899 · Cited by 13 · see citing works
Meijvis, S. C. A., Cornips, M. C. A., Endeman, H., Ruven, H. J. T., Danser, A. H. J., Biesma, D. H., Leufkens, H. G. M., Bos, W. J. W., & van de Garde, E. M. W. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.626 · Cited by 12 · see citing works
Meurer, M., Ebert, K., Schweda, F., & Höcherl, K. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2183-3 · Cited by 12 · see citing works
Perioperative Hypertensive Crisis
Fontes, M. L., & Varón, J. (2012) · International Anesthesiology Clinics · doi:10.1097/aia.0b013e31825430fd · Cited by 11 · see citing works
Чумаченко, А. Г., Grigoriev, E. K., & Писарев, В. М. (2021) · General Reanimatology · doi:10.15360/1813-9779-2021-5-35-51 · Cited by 11 · see citing works
Bernardelli, A. K., Silva, R. D. C. V. D. A. F. D., Corrêa, T., & da Silva‐Santos, J. E. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0514 · Cited by 11 · see citing works
Roles of Angiotensin II as Vasopressor in Vasodilatory Shock
Lumlertgul, N., & Ostermann, M. (2020) · Future Cardiology · doi:10.2217/fca-2020-0019 · Cited by 10 · see citing works
Dong, L., Li, H., Zhang, S., & Su, L. (2018) · Medicine · doi:10.1097/md.0000000000010362 · Cited by 10 · see citing works
Zhan, Z., Lian, Z., & Bai, H. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308557 · Cited by 9 · see citing works
Putowski, Z., Pluta, M. P., Rachfalska, N., Krzych, Ł. J., & Backer, D. D. (2023) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2023.05.028 · Cited by 8 · see citing works
Tsantes, A. Ε., Tsangaris, I., Kopterides, P., Nikolopoulos, G. K., Kalamara, E., Antonakos, G., Kapsimali, V., Gialeraki, A., Dimopoulou, I., Orfanos, S. E., et al. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.752 · Cited by 8 · see citing works
Shi, S., Pan, X., Feng, H., Zhang, S., Shi, S., & Lin, W. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06888-w · Cited by 7 · see citing works
Zheng, X., Xu, Z., Xu, L., Wang, L., Qin, S., Liu, Y., Dong, S., & Tang, L. (2024) · Inflammation · doi:10.1007/s10753-024-02037-y · Cited by 7 · see citing works
Asfar, P., Chawla, L. S., Lerolle, N., & Radermacher, P. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000436 · Cited by 7 · see citing works
Kobayashi, D., Kuriyama, N., Yanase, F., Takahashi, O., Aoki, K., & Komatsu, Y. (2019) · Journal of Nephrology · doi:10.1007/s40620-019-00603-4 · Cited by 7 · see citing works
A Saudi Heart Association Position Statement on Cardiovascular Diseases and Diabetes Mellitus
AlHabeeb, W., Elasfar, A., Kinsara, A. J., Aljizeeri, A. H., Jelaidan, I., Alghalayini, K. W., AlKheraiji., M. F., Akbar, M. A. J., Lawand, S., Alyousif, S. M., et al. (2024) · Journal of the Saudi Heart Association · doi:10.37616/2212-5043.1407 · Cited by 6 · see citing works
Jakob, S. M., Bracht, H., Porta, F., Balsiger, B. M., Brander, L., Knuesel, R., Feng, H.-Q., Kolarova, A., Ma, Y., & Takala, J. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00433.2011 · Cited by 6 · see citing works
Vieweg, R., Järemo, M., Steinvall, I., Elmasry, M., Abdelrahman, I., & Sjöberg, F. (2020) · PubMed Central · Cited by 6 · see citing works
Role of the renin-angiotensin-aldosterone system in sepsis and its therapeutic targets
Chen, X., Shao, M. L., Liu, Y., Zhou, J., Cao, F., Liu, Y., Qiu, G., Jiang, T., Huang, M., & Zhang, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115192 · Cited by 5 · see citing works
D’Elia, J. A., Gleason, R. E., Monaco, A. P., & Weinrauch, L. A. (2016) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s121492 · Cited by 5 · see citing works
Dysnatremia and mortality: do sweat the small stuff...
Klinck, J. R., McNeill, L., & Menon, D. K. (2013) · Critical Care · doi:10.1186/cc12560 · Cited by 5 · see citing works
Pharmacologic Agents for the Treatment of Vasodilatory Shock
Knotzer, H., Poidinger, B., & Kleinsasser, A. T. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190704101907 · Cited by 5 · see citing works
Angiotensin II in Septic Shock
Corrêa, T. D., Takala, J. A., & Jakob, S. M. (2015) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-13761-2_10 · Cited by 5 · see citing works
BAYKAN, S., Bıçakcıoğlu, M., Bulut, N., Yücel, N., Ersoy, Y., Uysal, N. K., & Özer, A. B. (2022) · Minerva Anestesiologica · doi:10.23736/s0375-9393.22.16766-0 · Cited by 4 · see citing works
Shih, C., Chen, S., Chang, W., Tsai, H.-J., Huang, H.-C., Wu, C., & Tsao, C. (2023) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000911 · Cited by 4 · see citing works
Lee, G. T., Ko, B. S., Kim, D. S., Kim, M., Park, J. E., Hwang, S. Y., Jeong, D., Chung, C. R., Kang, H., Oh, J., et al. (2024) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.0425 · Cited by 3 · see citing works
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19
Wen, T.-Z., Li, T., Chen, X., Chen, H.-Y., Wang, S., Fu, W.-J., Xiao, S., Luo, J., Tang, R., Ji, J.-L., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155980 · Cited by 3 · see citing works
Year in review 2010: Critical Care - cardiology
Backer, D. D., & Scolletta, S. (2011) · Critical Care · doi:10.1186/cc10542 · Cited by 3 · see citing works
Olivier, P., Moal, V., Saulnier, P., Lasocki, S., Radermacher, P., & Asfar, P. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05912-7 · Cited by 3 · see citing works
Fundamental role of Warburg effect in various pathophysiological processesPreprint
Vasanthakumar, N. (2017) · doi:10.31219/osf.io/gq8hx · Cited by 3 · see citing works
Chen, C.-E., Chou, R., Guo, J., Lu, Y., Chang, C., Wu, C.-H., & Huang, P. (2025) · PLoS ONE · doi:10.1371/journal.pone.0330668 · Cited by 2 · see citing works
Shrestha, D. B., Sedhai, Y. R., Oli, P. R., Proskuriakova, E., Adelkhanova, A., Shtembari, J., Khan, T. M. A., Singh, K., Ahmed, M. A., Waheed, I., et al. (2023) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001491 · Cited by 2 · see citing works
Changes in Insulin-like Growth Factor-1 Level in Patients with Sepsis and Septic Shock
Lee, S. H., Park, B. H., Song, J. H., Kim, S. Y., Chung, K. S., Kim, E. Y., Jung, J. Y., Kim, Y. S., Kim, S. I., Chang, J., et al. (2016) · The Korean Journal of Critical Care Medicine · doi:10.4266/kjccm.2016.00024 · Cited by 2 · see citing works
Fundamental role of warburg effect in various pathophysiological processes
Vasanthakumar, N. (2018) · International Journal of Clinical and Experimental Physiology · doi:10.4103/ijcep.ijcep_55_17 · Cited by 2 · see citing works
Bui, A., Helgeson, S. A., Guru, P. K., & Sanghavi, D. (2020) · BMJ Case Reports · doi:10.1136/bcr-2019-233432 · Cited by 2 · see citing works
Patel, J. S., Hidalgo, D. C., Capistrano, I., Mancl, E. E., & Rech, M. A. (2021) · Journal of Pharmacy Practice · doi:10.1177/08971900211048623 · Cited by 2 · see citing works
Beta-adrenergic blocker treatment for COVID-19Preprint
Vasanthakumar, N. (2020) · doi:10.31219/osf.io/wdp4g · Cited by 2 · see citing works
Dlouhý, P., Petráš, M., Lesná, I. K., Máčalík, R., Polák, J., Jabor, A., Filová, V., Pitha, J. V., Kuchar, O., & Rosina, J. (2026) · Vaccine · doi:10.1016/j.vaccine.2026.128535 · Cited by 1 · see citing works
Clover-Brown, I., Fuhrman, D. Y., & Stanski, N. L. (2026) · Pediatric Nephrology · doi:10.1007/s00467-026-07487-0 · Cited by 1 · see citing works
The Autonomic Cardiorenal Crosstalk: Pathophysiology and Implications for Heart Failure Management
Costanzo, M. R., & Gronda, E. (2015) · Springer eBooks · doi:10.1007/978-3-319-24993-3_10 · Cited by 1 · see citing works
Pathogenesis and Neuroendocrine Immunology
Straub, R. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-803321-0.00002-1 · Cited by 1 · see citing works
Classification of Cardiorenal Syndrome
Lullo, L. D., & Bellasi, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44942-7.00110-2 · Cited by 1 · see citing works
- Authors
- Doerschug, K. C., Delsing, A. S., Schmidt, G. A., & Ashare, A.
- Affiliations
- University of Iowa (US)
- Dartmouth College (US)
- Corresponding author
- Doerschug, Kevin C
- Venue
- Critical Care
- Published
- 2010-02-22
- Volume
- 14
- Issue
- 1
- Pages
- R24-R24
- ISSN
- 1364-8535 (ISSN-L)
- PMC
- PMC2875539
- OpenAlex
- W2134540051
- Cited by
- 119
- References
- 45
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Critical Care (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (K08DK073519-AA)
- National Heart, Lung, and Blood Institute (K23HL071246)
- National Institute of Allergy and Infectious Diseases (L30 AI062287)
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK084057, K08DK073519)
- National Center for Research Resources (UL1RR024979)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- renin-angiotensin system, severe sepsis, microvascular dysfunction, angiotensin II, plasma renin activity, reactive hyperemia, organ failure, septic shock, near-infrared spectroscopy, forearm ischemia
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prospective Studies, Renin-Angiotensin System, Case-Control Studies, Sepsis, Microvessels
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