The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
Open accessAbstract
Introduction: Serum creatinine concentration (sCr) is the marker used for diagnosing and staging acute kidney injury (AKI) in the RIFLE and AKIN classification systems, but is influenced by several factors including its volume of distribution. We evaluated the effect of fluid accumulation on sCr to estimate severity of AKI. Methods: In 253 patients recruited from a prospective observational study of critically-ill patients with AKI, we calculated cumulative fluid balance and computed a fluid-adjusted sCr concentration reflecting the effect of volume of distribution during the development phase of AKI. The time to reach a relative 50% increase from the reference sCr using the crude and adjusted sCr was compared. We defined late recognition to estimate severity of AKI when this time interval to reach 50% relative increase between the crude and adjusted sCr exceeded 24 hours. Results: The median cumulative fluid balance increased from 2.7 liters on day 2 to 6.5 liters on day 7. The difference between adjusted and crude sCr was significantly higher at each time point and progressively increased from a median difference of 0.09 mg/dL to 0.65 mg/dL after six days. Sixty-four (25%) patients met criteria for a late recognition to estimate severity progression of AKI. This group of patients had a lower urine output and a higher daily and cumulative fluid balance during the development phase of AKI. They were more likely to need dialysis but showed no difference in mortality compared to patients who did not meet the criteria for late recognition of severity progression. Conclusions: In critically-ill patients, the dilution of sCr by fluid accumulation may lead to underestimation of the severity of AKI and increases the time required to identify a 50% relative increase in sCr. A simple formula to correct sCr for fluid balance can improve staging of AKI and provide a better parameter for earlier recognition of severity progression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B. A., Ronco, C., Warnock, D. G., Levin, A., & the Acute Kidney Injury Network (2007) · Critical Care · doi:10.1186/cc5713 · Cited by 7,048
Self-citationBellomo, R., Ronco, C., Kellum, J. A., Mehta, R. L., Palevsky, P., & workgroup, T. A. (2004) · Critical Care · doi:10.1186/cc2872 · Cited by 6,781
Self-citationComparison of Two Fluid-Management Strategies in Acute Lung Injury
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa062200 · Cited by 3,538
Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized Patients
Chertow, G. M., Burdick, E., Honour, M., Bonventre, J. V., & Bates, D. W. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004090740 · Cited by 3,408
Self-citationHoste, E. A., Clermont, G., Kersten, A., Venkataraman, R., Angus, D. C., De Bacquer, D., & Kellum, J. A. (2006) · Critical Care · doi:10.1186/cc4915 · Cited by 1,471
Independent Association between Acute Renal Failure and Mortality following Cardiac Surgery
Chertow, G. M., Levy, E. M., Hammermeister, K. E., Grover, F., & Daley, J. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00058-8 · Cited by 1,177
Self-citationSpectrum of acute renal failure in the intensive care unit: The PICARD experience
Mehta, R. L., Pascual, M. T., Soroko, S., Savage, B. R., Himmelfarb, J., Ikizler, T. A., Paganini, E. P., & Chertow, G. M. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00927.x · Cited by 962
Self-citationAn assessment of the RIFLE criteria for acute renal failure in hospitalized patients*
Uchino, S., Bellomo, R., Goldsmith, D., Bates, S., & Ronco, C. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000224227.70642.4f · Cited by 934
Metnitz, P. G. H., Krenn, C. G., Steltzer, H., Lang, T., Ploder, J., Lenz, K., Le Gall, J.-R., & Druml, W. (2002) · Critical Care Medicine · doi:10.1097/00003246-200209000-00016 · Cited by 919
Incidence and Outcomes in Acute Kidney Injury: A Comprehensive Population-Based Study
Ali, T., Khan, I., Simpson, W., Prescott, G., Townend, J., Smith, W., & MacLeod, A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070756 · Cited by 825
Cited by
Mehta, R. L., Cerdá, J., Burdmann, E. A., Tonelli, M., García-García, G., Jha, V., Susantitaphong, P., Rocco, M., Vanholder, R., Sever, M. S., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60126-x · Cited by 1,154
Self-citation(2012) · Kidney International Supplements · doi:10.1038/kisup.2011.32 · Cited by 757
Acute kidney injury-epidemiology, outcomes and economics
Rewa, O., & Bagshaw, S. M. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.282 · Cited by 734
The definition of acute kidney injury and its use in practice
Thomas, M. E., Blaine, C., Dawnay, A., Devonald, M. A. J., Ftouh, S., Laing, C., Latchem, S., Lewington, A., Milford, D. V., & Ostermann, M. (2015) · Kidney International · doi:10.1038/ki.2014.328 · Cited by 722
Malbrain, M. L. N. G., Van Regenmortel, N., Saugel, B., De Tavernier, B., Van Gaal, P.-J., Joannes-Boyau, O., Teboul, J.-L., Rice, T. W., Mythen, M., & Monnet, X. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0402-x · Cited by 632
Metadata
- Authors
- Macedo, E., Bouchard, J., Soroko, S. H., Chertow, G. M., Himmelfarb, J., Ikizler, T. A., Paganini, E. P., Mehta, R. L., & study, F. T. P. T. I. C. I. A. R. D. (.
- Venue
- Critical Care
- Published
- 2010-05-06
- Volume
- 14
- Issue
- 3
- Pages
- R82-R82
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2098441893
- Cited by
- 416
- References
- 25
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients. https://app.cochat.ai/papers/10.1186/cc9004
- The paper
- Macedo, E., Bouchard, J., Soroko, S. H., Chertow, G. M., Himmelfarb, J., Ikizler, T. A., Paganini, E. P., Mehta, R. L., & study, F. T. P. T. I. C. I. A. R. D. (. (2010). Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients. Critical Care. https://doi.org/10.1186/cc9004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
