The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index, and 1 are not checked yet.
The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia
Open accessAbstract
INTRODUCTION: Timely diagnosis of invasive candidiasis (IC) remains difficult as the clinical presentation is not specific and blood cultures lack sensitivity and need a long incubation time. Thus, non-culture-based methods for diagnosing IC have been developed. Mannan antigen (Mn) and anti-mannan antibodies (A-Mn) are present in patients with IC. On behalf of the Third European Conference on Infections in Leukemia, the performance of these tests was analysed and reviewed. METHODS: The literature was searched for studies using the commercially available sandwich enzyme-linked immunosorbent assays (Platelia™, Bio-Rad Laboratories, Marnes-la-Coquette, France) for detecting Mn and A-Mn in serum. The target condition of this review was IC defined according to 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. Sensitivity, specificity and diagnostic odds ratios (DOR) were calculated for Mn, A-Mn and combined Mn/A-Mn testing. RESULTS: Overall, 14 studies that comprised 453 patients and 767 controls were reviewed. The patient populations included in the studies were mainly haematological and cancer cases in seven studies and mainly intensive care unit and surgery cases in the other seven studies. All studies but one were retrospective in design. Mn sensitivity was 58% (95% confidence interval [CI], 53-62); specificity, 93% (95% CI, 91-94) and DOR, 18 (95% CI 12-28). A-Mn sensitivity was 59% (95% CI, 54-65); specificity, 83% (95% CI, 79-97) and DOR, 12 (95% CI 7-21). Combined Mn/A-Mn sensitivity was 83% (95% CI, 79-87); specificity, 86% (95% CI, 82-90) and DOR, 58 (95% CI 27-122). Significant heterogeneity of the studies was detected. The sensitivity of both Mn and A-Mn varied for different Candida species, and it was the highest for C. albicans, followed by C. glabrata and C. tropicalis. In 73% of 45 patients with candidemia, at least one of the serological tests was positive before the culture results, with mean time advantage being 6 days for Mn and 7 days for A-Mn. In 21 patients with hepatosplenic IC, 18 (86%) had Mn or A-Mn positive test results at a median of 16 days before radiological detection of liver or spleen lesions. CONCLUSIONS: Mn and A-Mn are useful for diagnosis of IC. The performance of combined Mn/A-Mn testing is superior to either Mn or A-Mn testing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“An assay that detects both mannan and anti-mannan IgG (Platelia, Bio-rad, Hercules, CA, USA) has a combined sensitivity and specificity of 83% and 86%, respectively [81].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [81]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917
Self-citationEpidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · cited 1×
“Introduction Invasive candidiasis (IC) is an important infectious complication in immunocompromised patients and is associated with severe morbidity and high mortality [1].”
BackgroundPappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191
Self-citationAşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315
Statistics Notes: The odds ratio
Bland, J. M. (2000) · BMJ · doi:10.1136/bmj.320.7247.1468 · Cited by 1,298
Parczewska, O. K., Posaconazol, przeciwgrzybicze, L., Anidulafungina, Micafungina, & wrażliwość, O. (2009) · Cited by 656
Review: Cell wall assembly in yeast
Klis, F. M. (1994) · Yeast · doi:10.1002/yea.320100702 · Cited by 552
Edwards, Jr., Bodey, G. P., Bowden, R. A., Buchner, T., de Pauw, B. E., Filler, S. G., Ghannoum, M. A., Glauser, M., Herbrecht, R., Kauffman, C. A., et al. (1997) · Clinical Infectious Diseases · doi:10.1086/514504 · Cited by 418
Self-citationWalsh, T. J., Hathorn, J. W., Sobel, J. D., Merz, W. G., Sánchez, V., Maret, S., BUCKLEY, H. R., Pfaller, M. A., Schaufele, R. L., Sliva, C., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104113241504 · Cited by 246
Laboratory diagnosis of invasive candidiasis
Jones, J. M. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.32 · Cited by 221
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–320 of 320
Le point sur les endocardites infectieuses
Bertholom, C. (2023) · Option/Bio · doi:10.1016/s0992-5945(23)00354-9
Diagnostics of Candida and Candidiasis: Current Methods and Future Perspectives
Banik, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-4909-6_1
Candidemie e candidosi invasive
Benitha, Y., & Bleibtreu, A. (2025) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(24)49999-4
Candidemia y candidiasis invasiva
Benitha, Y., & Bleibtreu, A. (2025) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(25)50394-8
Benders, P. M. B., Schouten, J. A., Vena, A., Buil, J. B., Bronkhorst, E., & Bassetti, M. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-10644-9 · Cited by 1
Greenberg, R. G., Fisher, B. T., & Otto, W. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-82763-8.00217-x
Hamamah, S., Teskey, G., Chow, W., Wilder, E., Reddy, L., & Hai, F. (2025) · Cureus · doi:10.7759/cureus.88115
Carr, A. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-11611-7.00019-0
Abdullah, A., Khan, M. T., Khan, Z., Iqbal, H., Bukhari, S. M., Khan, H., Ahmad, S., & Salman, M. (2025) · BioScientific Review · doi:10.32350/bsr.73.03
Fongémies : épidémiologie, diagnostic et conduite à tenir
Dellière, S., Chantelot, L., Garnaud, C., & Cornet, M. (2026) · EMC - Biologie Médicale · doi:10.1016/s2211-9698(25)48322-8
Interactions hôte-candida au cours des péritonites fongiques graves de réanimation
Novy, E. (2024) · theses.fr (ABES) · doi:10.70675/bb875beazbffcz45cdz85b2z2ac1b68c7226
Old and Modern Identification Techniques of medically important yeasts
Bhattacharyya, S. (2025) · Eastern Journal of Medical Sciences · doi:10.32677/ejms.v10i4.7832
Lu, G., Dan, J., Yang, X., Tan, L., & Jiang, J. (2026) · Biosafety and Health · doi:10.1016/j.bsheal.2026.05.006
Krylov, V. B., Kuznetsov, A. N., Dorokhova, V. S., Tsarapaev, P. V., Кушлинский, Н. Е., & Nifantiev, N. E. (2026) · Russian Journal for Personalized Medicine · doi:10.18705/2782-3806-2026-6-3-200-210
The future of fungal diagnostics: What’s next in laboratory testing for invasive fungal infection?
Southern-Thomas, R., Goyal, S., Wild, A. L., & Stone, N. R. H. (2026) · Medical Mycology · doi:10.1093/mmy/myag085
Neri, G., Mazza, G., Ielapi, J., Russo, A., Serapide, F., Mastrangelo, H., Mesiti, A., Caroleo, Z., Fresilli, S., Bruni, A., et al. (2026) · Journal of Fungi · doi:10.3390/jof12090681
Athouf, D. A., Mohammed, H. A., & Al-musawy, F. A. B. (2026) · Indonesian Journal of Microbiology · doi:10.47134/ijm.v3i1.6038
Metadata
- Authors
- Mikulska, M., Calandra, T., Sanguinetti, M., Poulain, D., Viscoli, C., & the Third European Conference on Infections in Leukemia Group
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Centre Hospitalier Universitaire Vaudois (CH)
- Università Cattolica del Sacro Cuore (IT)
- Inserm (FR)
- Corresponding author
- Mikulska, Małgorzata
- Venue
- Critical Care
- Published
- 2010-12-08
- Volume
- 14
- Issue
- 6
- Pages
- R222-R222
- ISSN
- 1364-8535 (ISSN-L)
- PMC
- PMC3219989
- OpenAlex
- W2141329212
- Cited by
- 319
- References
- 38
- Citations by year
- 2026: 8 · 2025: 25 · 2024: 10 · 2023: 25 · 2022: 17 · 2021: 22 · 2020: 25 · 2019: 21 · 2018: 19 · 2017: 14 · 2016: 22 · 2015: 27 · 2014: 29 · 2013: 29 · 2012: 19
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Critical Care (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- IRIS (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- mannan antigen, anti-mannan antibodies, candidemia, diagnostic accuracy, sensitivity and specificity, Candida species, Candida albicans, Candida glabrata, Candida tropicalis, hematologic malignancies, intensive care unit patients, sandwich ELISA
- MeSH terms
- Animals, Antibodies, Fungal, Antigens, Fungal, Candida, Congresses as Topic, Europe, Humans, Leukemia, Mannans, Randomized Controlled Trials as Topic, Practice Guidelines as Topic, Candidiasis, Invasive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
