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Cited by 418Antifungal resistance and susceptibilityFungal Infections and StudiesOcular Infections and Treatments

International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections

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Edwards, Jr., John E., Bodey, Gerald P., Bowden, Raleigh A., Buchner, Thomas, de Pauw, Ben E., Filler, Scott G., Ghannoum, Mahmoud A., Glauser, Michel +14 more·1997·Clinical Infectious Diseases
DOI 10.1086/514504
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Abstract

Because of the rapidly increasing incidence of serious candidal infections, a consensus conference of 22 investigators from the United States, Europe, and Japan was held to discuss strategies for the prevention and treatment of deep-organ infections caused by Candida species. Commonly asked questions concerning the management of candidal infections were selected for discussion by the participating investigators. Possible answers to the questions were developed by the investigators, who then voted anonymously for their preferences. In certain instances, unanimity or a strong consensus was the result. In all cases, the full spectrum of responses was recorded and is presented in this report. The forms of candidal infection addressed included candidemia, candiduria, hepatosplenic candidiasis (chronic systemic candidiasis), candidal endophthalmitis, and candidal peritonitis. Prevention and treatment strategies were considered for patients who have undergone surgery, for neutropenic and nonneutropenic patients, and for patients who have undergone bone marrow and solid organ transplantation. The therapeutic roles of amphotericin B (standard and lipid formulations) and the azoles were considered.

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Crossref · 10.1086/514504

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  • Amphotericin B deoxycholate has a broader spectrum than fluconazole.

    “many authorities prefer amphotericin B deoxycholate (у0.7 mg/kg per day) [126, 127] because of its broader spectrum.”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [126]

  • Fluconazole has been used successfully in clinically unstable patients infected with an unspeciated isolate.

    “For clinically unstable patients infected with an unspeciated isolate, fluconazole has been used successfully”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [126]

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Authors
Edwards, Jr., Bodey, G. P., Bowden, R. A., Buchner, T., de Pauw, B. E., Filler, S. G., Ghannoum, M. A., Glauser, M., Herbrecht, R., Kauffman, C. A., Kohno, S., Martino, P., Meunier, F., Mori, T., Pfaller, M. A., Rex, J. H., Rogers, T. R., Rubin, R. H., Solomkin, J., Viscoli, C., Walsh, T. J., & White, M.
Affiliations
University of California, Los Angeles (US)
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1997-07
Volume
25
Issue
1
Pages
43-59
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/514504
OpenAlex
W2106715375
Cited by
418
References
77
Citations by year
2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 2 · 2012: 5
FWCI
25.65
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • National Institutes of Health (n01ai015082-002, n01ai065296-009)
  • National Institute of Allergy and Infectious Diseases (N01AI65296, R01AI019990, N01 AI15082, R01-AI19990-12)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
candidiasis, Candida, candidemia, candiduria, hepatosplenic candidiasis, antifungal therapy, amphotericin B, lipid amphotericin B, azoles, neutropenia, bone marrow transplantation, solid organ transplantation, surgical patients, infection control, consensus recommendations
MeSH terms
Animals, Antifungal Agents, Candidiasis, Humans

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