CoChat
Sign Up
Cited by 112

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z

Rens, Willem, O'Brien, Patricia CM, Grützner, Frank, Clarke, Oliver, Graphodatskaya, Daria, Tsend-Ayush, Enkhjargal, Trifonov, Vladimir A, Skelton, Helen, Wallis, Mary C, Johnston, Steve, Veyrunes, Frederic, Graves, Jennifer AM, Ferguson-Smith, Malcolm A·2007·Genome Biology
DOI 10.1186/gb-2007-8-11-r243PMC PMC2258203
Open this paper in CoChat — free account

Abstract

Background: Sex-determining systems have evolved independently in vertebrates. Placental mammals and marsupials have an XY system, birds have a ZW system. Reptiles and amphibians have different systems, including temperature-dependent sex determination, and XY and ZW systems that differ in origin from birds and placental mammals. Monotremes diverged early in mammalian evolution, just after the mammalian clade diverged from the sauropsid clade. Our previous studies showed that male platypus has five X and five Y chromosomes, no SRY, and DMRT1 on an X chromosome. In order to investigate monotreme sex chromosome evolution, we performed a comparative study of platypus and echidna by chromosome painting and comparative gene mapping. Results: Chromosome painting reveals a meiotic chain of nine sex chromosomes in the male echidna and establishes their order in the chain. Two of those differ from those in the platypus, three of the platypus sex chromosomes differ from those of the echidna and the order of several chromosomes is rearranged. Comparative gene mapping shows that, in addition to bird autosome regions, regions of bird Z chromosomes are homologous to regions in four platypus X chromosomes, that is, X 1, X 2, X 3, X 5, and in chromosome Y 1. Conclusion: Monotreme sex chromosomes are easiest to explain on the hypothesis that autosomes were added sequentially to the translocation chain, with the final additions after platypus and echidna divergence. Genome sequencing and contig anchoring show no homology yet between platypus and therian Xs; thus, monotremes have a unique XY sex chromosome system that shares some homology with the avian Z.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/gb-2007-8-11-r243

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Only the first X chromosomes are ancestral to both echidna and platypus, and all are unrelated to the mammalian X chromosomes, consistent with their independent evolution.

    “Only the first X chromosomes are ancestral to both echidna and platypus (Rens et al., 2007), and all are unrelated to the mammalian X chromosomes (Figure 2—figure supplement 1), consistent with their independent evolution (Rens et al., 2007).”

    From GENESPACE tracks regions of interest and gene copy number variation across multiple genomes (2022) · cites this paper as Rens et al., 2007

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 31

  1. Flannery TF, Groves CP: A revision of the genus Zaglossus (Monotremata, Tachyglossidae), with description of new species and subspecies. Mammalia. Mammalia. 1998, 62: 367-396. · DOI
  2. Matthey R: Les Chromosomes des Vertebrées. 1949, Lucerne: F Rouge
  3. VanBrink JM: L'expression morphologique de la diagametie chez les sauropsids et les monotremes. Chromosoma. 1959, 10: 1-72. 10.1007/BF00396564. · DOI
  4. Bick YA, Murtagh C, Sharman GB: The chromosomes of an egg-laying mammal Tachyglossus aculeatus (the echidna). Cytobios. 1973, 7: 233-243.
  5. Grützner F, Rens W, Tsend-Ayush E, El Mogharbel N, O'Brien PC, Jones RC, Ferguson-Smith MA, Marshall Graves JA: In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes. Nature. 2004, 432: 913-917. 10.1038/nature03021. · DOI
  6. Rens W, Grutzner F, O'Brien PC, Fairclough H, Graves JA, Ferguson-Smith MA: Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution. Proc Natl Acad Sci USA. 2004, 101: 16257-16261. 10.1073/pnas.0405702101. · DOI
  7. El Mogharbel N, Wakefield M, Deakin JE, Tsend-Ayush E, Grutzner F, Alsop A, Ezaz T, Marshall Graves JA: DMRT gene cluster analysis in the platypus: New insights into genomic organization and regulatory regions. Genomics. 2007, 89: 10-21. 10.1016/j.ygeno.2006.07.017. · DOI
  8. Nanda I, Haaf T, Schartl M, Schmid M, Burt DW: Comparative mapping of Z-orthologous genes in vertebrates: implications for the evolution of avian sex chromosomes. Cytogenet Genome Res. 2002, 99: 178-184. 10.1159/000071591. · DOI
  9. Waters PD, Delbridge ML, Deakin JE, El Mogharbel N, Kirby PJ, Carvalho-Silva DR, Graves JA: Autosomal location of genes from the conserved mammalian X in the platypus (Ornithorhynchus anatinus): implications for mammalian sex chromosome evolution. Chromosome Res. 2005, 13: 401-410. 10.1007/s10577-005-0978-5. · DOI
  10. Grafodatskaya D, Rens W, Wallis MC, Trifonov V, O'Brien PC, Clarke O, Graves JA, Ferguson-Smith MA: Search for the sex-determining switch in monotremes: Mapping WT1, SF1, LHX1, LHX2, FGF9, WNT4, RSPO1 and GATA4 in platypus. Chromosome Res. 2007, 15: 777-785. 10.1007/s10577-007-1161-y. · DOI
  11. Hore TA, Koina E, Wakefield MJ, Marshall Graves JA: The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals. Chromosome Res. 2007, 15: 147-161. 10.1007/s10577-007-1119-0. · DOI · Paper page
  12. Mitchell MJ, Wilcox SA, Watson JM, Lerner JL, Woods DR, Scheffler J, Hearn JP, Bishop CE, Graves JA: The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome. Hum Mol Genet. 1998, 7: 429-434. 10.1093/hmg/7.3.429. · DOI
  13. Spencer JA, Watson JM, Lubahn DB, Joseph DR, French FS, Wilson EM, Graves JA: The androgen receptor gene is located on a highly conserved region of the X chromosomes of marsupial and monotreme as well as eutherian mammals. J Hered. 1991, 82: 134-139. · DOI
  14. Watson JM, Spencer JA, Riggs AD, Graves JA: The X chromosome of monotremes shares a highly conserved region with the eutherian and marsupial X chromosomes despite the absence of X chromosome inactivation. Proc Natl Acad Sci USA. 1990, 87: 7125-7129. 10.1073/pnas.87.18.7125. · DOI
  15. Watson JM, Spencer JA, Riggs AD, Graves JA: Sex chromosome evolution: platypus gene mapping suggests that part of the human X chromosome was originally autosomal. Proc Natl Acad Sci USA. 1991, 88: 11256-11260. 10.1073/pnas.88.24.11256. · DOI
  16. Wilcox SA, Watson JM, Spencer JA, Graves JA: Comparative mapping identifies the fusion point of an ancient mammalian X-autosomal rearrangement. Genomics. 1996, 35: 66-70. 10.1006/geno.1996.0323. · DOI
  17. Rens W, Moderegger K, Skelton H, Clarke O, Trifonov V, Ferguson-Smith MA: A procedure for image enhancement in chromosome painting. Chromosome Res. 2006, 14: 497-503. 10.1007/s10577-006-1056-3. · DOI
  18. Watson JM, Meyne J, Graves JAM: Chromosomal composition and position in the echidna meiotic translocation chain. Platypus and Echidnas. Edited by: Augee M. 1992, Sydney: Royal Zoological Society of New South Wales, 53-63.
  19. Wrigley JM, Graves JA: Karyotypic conservation in the mammalian order monotremata (subclass Prototheria). Chromosoma. 1988, 96: 231-247. 10.1007/BF00302363. · DOI
  20. Delbridge ML, Wallis MC, Kirby PJ, Alsop AE, Grutzner F, Graves JA: Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridization. Cytogenet Genome Res. 2006, 112: 342L-10.1159/000089902. · DOI
  21. Kirby PJ, Waters PD, Delbridge M, Svartman M, Stewart AN, Nagai K, Graves JA: Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution. Cytogenet Genome Res. 2002, 98: 96-100. 10.1159/000068539. · DOI
  22. Wallis MC, Delbridge ML, Pask AJ, Alsop AE, Grutzner F, O'Brien PCM, Rens W, Ferguson-Smith MA, Graves JAM: Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role. Cytogenet Genome Res. 2007, 116: 232-234. 10.1159/000098192. · DOI
  23. Murtagh CE: Unique cytogenetic system in monotremes. Chromosoma. 1977, 65: 37-57. 10.1007/BF00293129. · DOI
  24. Grützner F, Ashley T, Rowell DM, Marshall Graves JA: How did the platypus get its sex chromosome chain? A comparison of meiotic multiples and sex chromosomes in plants and animals. Chromosoma. 2006, 115: 75-88. 10.1007/s00412-005-0034-4. · DOI
  25. Dohm JC, Tsend-Ayush E, Reinhardt R, Grutzner F, Himmelbauer H: Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes. Genome Biol. 2007, 8: R175-10.1186/gb-2007-8-8-r175. · DOI
  26. Ashley T: Chromosome chains and platypus sex: kinky connections. Bioessays. 2005, 27: 681-684. 10.1002/bies.20265. · DOI
  27. Lahn BT, Page DC: Four evolutionary strata on the human X chromosome. Science. 1999, 286: 964-967. 10.1126/science.286.5441.964. · DOI
  28. Rens W, O'Brien PC, Yang F, Graves JA, Ferguson-Smith MA: Karyotype relationships between four distantly related marsupials revealed by reciprocal chromosome painting. Chromosome Res. 1999, 7: 461-474. 10.1023/A:1009249813617. · DOI
  29. Hardt T, Himmelbauer H, Mann W, Ropers H, Haaf T: Towards identification of individual homologous chromosomes: comparative genomic hybridization and spectral karyotyping discriminate between paternal and maternal euchromatin in Mus musculus × M. spretus interspecific hybrids. Cytogenet Cell Genet. 1999, 86: 187-193. 10.1159/000015337. · DOI
  30. Weimer J, Kiechle M, Senger G, Wiedemann U, Ovens-Raeder A, Schuierer S, Kautza M, Siebert R, Arnold N: An easy and reliable procedure of microdissection technique for the analysis of chromosomal breakpoints and marker chromosomes. Chromosome Res. 1999, 7: 355-362. 10.1023/A:1009263913478. · DOI
  31. Sonnhammer EL, Koonin EV: Orthology, paralogy and proposed classification for paralog subtypes. Trends Genet. 2002, 18: 619-620. 10.1016/S0168-9525(02)02793-2. · DOI

Cited by

Sorted by citations

Metadata

Authors
Rens, W., O'Brien, P. C., Grützner, F., Clarke, O., Graphodatskaya, D., Tsend-Ayush, E., Trifonov, V. A., Skelton, H., Wallis, M. C., Johnston, S., Veyrunes, F., Graves, J. A., & Ferguson-Smith, M. A.
Venue
Genome Biology
Publisher
Springer Science and Business Media LLC
Published
2007-11-16
Volume
8
Issue
11
ISSN
1474-760X
DOI
10.1186/gb-2007-8-11-r243
PMC
PMC2258203
Cited by
112
References
4
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review