Molecular machines or pleiomorphic ensembles: signaling complexes revisited
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Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us away from investigating critical issues.
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A conventional mechanical description of protein complexes requiring well-defined quaternary structures is misleading because signaling and regulatory complexes are highly dynamic ensembles.
“Since signaling and other regulatory complexes typically consist of highly dynamic molecular ensembles a ‘conventional’ mechanical description of protein complexes that requires well-defined quaternary structures is misleading.534–535”
From Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell (2016) · cites this paper as [534]
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- Authors
- Mayer, B. J., Blinov, M. L., & Loew, L. M.
- Affiliations
- UConn Health (US)
- Corresponding author
- Mayer, Bruce J
- Venue
- Journal of Biology
- Published
- 2009
- Volume
- 8
- Issue
- 9
- Pages
- 81
- ISSN
- 1475-4924 (ISSN-L)
- PMC
- PMC2776906
- OpenAlex
- W2159629828
- Cited by
- 85
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 8
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u54rr022232-05)
- National Cancer Institute (R01CA082258)
- National Institute of General Medical Sciences (R01GM076570)
- National Center for Research Resources (U54-RR022232, P41RR013186)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- signaling complexes, molecular ensembles, molecular machines
- MeSH terms
- Algorithms, Binding Sites, Computer Simulation, Models, Molecular, Nucleic Acid Conformation, Phosphorylation, Protein Binding, Protein Conformation, Thermodynamics, Models, Statistical, Signal Transduction, Protein Folding, Computational Biology, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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