Cited by 85Receptor Mechanisms and SignalingProtein Structure and DynamicsGene Regulatory Network Analysis

Molecular machines or pleiomorphic ensembles: signaling complexes revisited

Open access
Mayer, Bruce J, Blinov, Michael L, Loew, Leslie M·2009·Journal of Biology

Abstract

Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us away from investigating critical issues.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/jbiol185

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Mayer, B. J., Blinov, M. L., & Loew, L. M.
Affiliations
UConn Health (US)
Corresponding author
Mayer, Bruce J
Venue
Journal of Biology
Published
2009
Volume
8
Issue
9
Pages
81
ISSN
1475-4924 (ISSN-L)
OpenAlex
W2159629828
Cited by
85
References
24
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 8
FWCI
3.46
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5u54rr022232-05)
  • National Cancer Institute (R01CA082258)
  • National Institute of General Medical Sciences (R01GM076570)
  • National Center for Research Resources (U54-RR022232, P41RR013186)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
signaling complexes, molecular ensembles, molecular machines
MeSH terms
Algorithms, Binding Sites, Computer Simulation, Models, Molecular, Nucleic Acid Conformation, Phosphorylation, Protein Binding, Protein Conformation, Thermodynamics, Models, Statistical, Signal Transduction, Protein Folding, Computational Biology, Adaptor Proteins, Signal Transducing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review