The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
Open accessAbstract
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release. Asthma is a complex genetic disorder that has been linked to polymorphisms in the IL-4 gene promoter and proteins involved in IL-4 signaling. Soluble recombinant IL-4 receptor lacks transmembrane and cytoplasmic activating domains and can therefore sequester IL-4 without mediating cellular activation. We report the results of initial clinical trials, which demonstrate clinical efficacy of this naturally occurring IL-4 antagonist as a therapeutic agent in asthma.
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CD4 + T Cells: Differentiation and Functions
Luckheeram, R. V., Zhou, R., Verma, A. D., & Xia, B. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/925135 · Cited by 1,381
Halim, T. Y. F., Krauß, R. H., Sun, A. C., & Takei, F. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.020 · Cited by 804
B cells responses and cytokine production are regulated by their immune microenvironment
Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.007 · Cited by 421
Interleukin-17 and innate immunity in infections and chronic inflammation
Isailovic, N., Daigo, K., Mantovani, A., & Selmi, C. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.04.006 · Cited by 363
von Holst, H., Nayak, P., Dembek, Z., Buehler, S., Echeverria, D., Fallacara, D., & John, L. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08160 · Cited by 167
Metadata
- Authors
- Steinke, J. W., & Borish, L.
- Venue
- Respiratory Research
- Published
- 2001-02-19
- Volume
- 2
- Issue
- 2
- Pages
- 66-70
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- DOI
- 10.1186/rr40
- OpenAlex
- W1947221834
- Cited by
- 444
- References
- 32
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- gold
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- Steinke, J. W., & Borish, L. (2001). Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respiratory Research. https://doi.org/10.1186/rr40
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
