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Cited by 444

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists

Open access
Steinke, John W, Borish, Larry·2001·Respiratory Research
DOI 10.1186/rr40
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Abstract

Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release. Asthma is a complex genetic disorder that has been linked to polymorphisms in the IL-4 gene promoter and proteins involved in IL-4 signaling. Soluble recombinant IL-4 receptor lacks transmembrane and cytoplasmic activating domains and can therefore sequester IL-4 without mediating cellular activation. We report the results of initial clinical trials, which demonstrate clinical efficacy of this naturally occurring IL-4 antagonist as a therapeutic agent in asthma.

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Metadata

Authors
Steinke, J. W., & Borish, L.
Venue
Respiratory Research
Publisher
Springer Science and Business Media LLC
Published
2001-02-19
Volume
2
Issue
2
Pages
66-70
ISSN
  • 1465-9921 (ISSN-L)
  • 1465-993X
DOI
10.1186/rr40
OpenAlex
W1947221834
Cited by
444
References
32
FWCI
6.45
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.