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Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells
Open accessAbstract
Silver nanoparticles (AgNPs) are prominent group of nanomaterials and are recognized for their diverse applications in various health sectors. This study aimed to synthesize the AgNPs using the leaf extract of Artemisia princeps as a bio-reductant. Furthermore, we evaluated the multidimensional effect of the biologically synthesized AgNPs in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma (A549) cells. UV-visible (UV-vis) spectroscopy confirmed the synthesis of AgNPs. X-ray diffraction (XRD) indicated that the AgNPs are specifically indexed to a crystal structure. The results from Fourier transform infrared spectroscopy (FTIR) indicate that biomolecules are involved in the synthesis and stabilization of AgNPs. Dynamic light scattering (DLS) studies showed the average size distribution of the particle between 10 and 40 nm, and transmission electron microscopy (TEM) confirmed that the AgNPs were significantly well separated and spherical with an average size of 20 nm. AgNPs caused dose-dependent decrease in cell viability and biofilm formation and increase in reactive oxygen species (ROS) generation and DNA fragmentation in H. pylori and H. felis. Furthermore, AgNPs induced mitochondrial-mediated apoptosis in A549 cells; conversely, AgNPs had no significant effects on L132 cells. The results from this study suggest that AgNPs could cause cell-specific apoptosis in mammalian cells. Our findings demonstrate that this environmentally friendly method for the synthesis of AgNPs and that the prepared AgNPs have multidimensional effects such as anti-bacterial and anti-biofilm activity against H. pylori and H. felis and also cytotoxic effects against human cancer cells. This report describes comprehensively the effects of AgNPs on bacteria and mammalian cells. We believe that biologically synthesized AgNPs will open a new avenue towards various biotechnological and biomedical applications in the near future.
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Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Cited by
Zhang, X.-F., Liu, Z.-G., Shen, W., & Gurunathan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091534 · Cited by 3,220
Self-citationSmart Nanomaterials in Cancer Theranostics: Challenges and Opportunities
Kashyap, B. K., Singh, V. V., Solanki, M. K., Kumar, A., Ruokolainen, J., & Kesari, K. K. (2023) · ACS Omega · doi:10.1021/acsomega.2c07840 · Cited by 348
Green Chemistry Synthesis of Silver Nanoparticles and Their Potential Anticancer Effects
Ratan, Z. A., Haidere, M. F., Nurunnabi, M., Shahriar, S. M., Ahammad, A. J. S., Shim, Y. Y., Reaney, M. J. T., & Cho, J. Y. (2020) · Cancers · doi:10.3390/cancers12040855 · Cited by 328
Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
Zhang, X.-F., Shen, W., & Gurunathan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101603 · Cited by 308
Self-citationFlores‐López, L. Z., Espinoza‐Gómez, H., & Somanathan, R. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3654 · Cited by 299
Metadata
- Authors
- Gurunathan, S., Jeong, J.-K., Han, J. W., Zhang, X.-F., Park, J. H., & Kim, J.-H.
- Venue
- Nanoscale Research Letters
- Published
- 2015-02-05
- Volume
- 10
- Issue
- 1
- Pages
- 35-35
- ISSN
- 1556-276X (ISSN-L)
- 1931-7573
- OpenAlex
- W2153448170
- Cited by
- 220
- References
- 3
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gurunathan, S., Jeong, J.-K., Han, J. W., Zhang, X.-F., Park, J. H., & Kim, J.-H. (2015). Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells. Nanoscale Research Letters. https://doi.org/10.1186/s11671-015-0747-0
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