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Cited by 138Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryNanotechnology research and applications

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Nanoparticles: A New Approach to Upgrade Cancer Diagnosis and Treatment

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Yu, Zhongyang, Gao, Lei, Chen, Kehan, Zhang, Wenqiang, Zhang, Qihang, Li, Quanwang, Hu, Kaiwen·2021·Nanoscale Research Letters
DOI 10.1186/s11671-021-03489-zPMC PMC8137776
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Abstract

Traditional cancer therapeutics have been criticized due to various adverse effects and insufficient damage to targeted tumors. The breakthrough of nanoparticles provides a novel approach for upgrading traditional treatments and diagnosis. Actually, nanoparticles can not only solve the shortcomings of traditional cancer diagnosis and treatment, but also create brand-new perspectives and cutting-edge devices for tumor diagnosis and treatment. However, most of the research about nanoparticles stays in vivo and in vitro stage, and only few clinical researches about nanoparticles have been reported. In this review, we first summarize the current applications of nanoparticles in cancer diagnosis and treatment. After that, we propose the challenges that hinder the clinical applications of NPs and provide feasible solutions in combination with the updated literature in the last two years. At the end, we will provide our opinions on the future developments of NPs in tumor diagnosis and treatment.

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Fig. 1 Schematic diagram of the sol–gel method
Fig. 1 Schematic diagram of the sol–gel methodCC BY · PubMed Central
Fig. 2 Diagrammatic illustration of imaging improved of NPs
Fig. 2 Diagrammatic illustration of imaging improved of NPsCC BY · PubMed Central
Fig. 3 Diagrammatic illustration of passive targeting of NPs
Fig. 3 Diagrammatic illustration of passive targeting of NPsCC BY · PubMed Central
Fig. 4 Diagrammatic illustration of active targeting of NPs
Fig. 4 Diagrammatic illustration of active targeting of NPsCC BY · PubMed Central
Fig. 5 Diagrammatic illustration of NPs for cryosurgery. a NPs protect health cells during cryosurgery. b NPs enhance the freezing damage and control the freezing coverage. c With the help of NPs, more ice has been formed
Fig. 5 Diagrammatic illustration of NPs for cryosurgery. a NPs protect health cells during cryosurgery. b NPs enhance the freezing damage and control the freezing coverage. c With the help of NPs, more ice has been formedCC BY · PubMed Central
Fig. 6 Diagrammatic illustration of NPs-mediated PDT and PTT. a NPs promote the generation of reactive oxygen. b NPs enhance tumor damage during PTT
Fig. 6 Diagrammatic illustration of NPs-mediated PDT and PTT. a NPs promote the generation of reactive oxygen. b NPs enhance tumor damage during PTTCC BY · PubMed Central

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Metadata

Authors
Yu, Z., Gao, L., Chen, K., Zhang, W., Zhang, Q., Li, Q., & Hu, K.
Affiliations
  • Beijing University of Chinese Medicine (CN)
  • China Agricultural University (CN)
  • University of New Brunswick (CA)
Corresponding author
Hu, Kaiwen
ORCID
Venue
Nanoscale Research Letters
Publisher
Springer Science and Business Media LLC
Published
2021-05-20
Volume
16
Issue
1
Pages
88-88
ISSN
1556-276X (ISSN-L)
DOI
10.1186/s11671-021-03489-z
PMC
PMC8137776
OpenAlex
W3162697468
Cited by
138
References
1
Citations by year
2026: 6 · 2025: 21 · 2024: 29 · 2023: 35 · 2022: 36 · 2021: 11
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Nanoscale Research Letters (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
Keywords
nanoparticles, cancer diagnosis, cancer therapy, tumor targeting, clinical translation, drug delivery, nanomedicine

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