Cited by 753Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

Jia, Gang, Han, Yong, An, Yanli, Ding, Yinan, He, Chen, Wang, Xihui, Tang, Qiusha·2018·Biomaterials

Abstract

Currently, glioma treatment is limited by two main factors: timely detection at onset or relapse and restriction of drugs by the blood-brain barrier (BBB) from entering the brain and influencing tumor growth. However, a safe BBB-traversing drug delivery system has brought new hope to glioma treatment. Exosomes have strong cargo-loading capacity and have the ability to cross the BBB. They can also be conferred with the ability for targeted delivery. Therefore, exosomes have great promise to be a targeted drug delivery vehicles. In this study, we firstly loaded superparamagnetic iron oxide nanoparticles (SPIONs) and curcumin (Cur) into exosomes and then conjugated the exosome membrane with neuropilin-1-targeted peptide (RGERPPR, RGE) by click chemistry to obtain glioma-targeting exosomes with imaging and therapeutic functions. When administered to glioma cells and orthotopic glioma models, we found that these engineered exosomes could cross the BBB smoothly and provided good results for targeted imaging and therapy of glioma. Furthermore, SPION-mediated magnetic flow hyperthermia (MFH) and Cur-mediated therapy also showed a potent synergistic antitumor effect. Therefore, the diagnostic and therapeutic effects on glioma were significantly improved, while reducing the side effects. We have designed a new type of glioma-targeting exosomes, which can carry nanomaterials and chemical agents for simultaneous diagnosis and treatment of glioma, thus providing a potential approach for improving the diagnosis and treatment effects of intracranial tumors.

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Crossref · 10.1016/j.biomaterials.2018.06.029

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Authors
Jia, G., Han, Y., An, Y., Ding, Y., He, C., Wang, X., & Tang, Q.
Affiliations
  • Southeast University (CN)
  • Zhongda Hospital Southeast University (CN)
Corresponding author
Tang, Qiusha
Venue
Biomaterials
Publisher
Elsevier BV
Published
2018-09
Volume
178
Pages
302-316
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2809103633
Cited by
753
References
43
Citations by year
2026: 47 · 2025: 118 · 2024: 139 · 2023: 125 · 2022: 136 · 2021: 104 · 2020: 55 · 2019: 26 · 2018: 3
FWCI
16.63
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81271635, 81301270)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
glioma, exosomes, neuropilin-1, blood-brain barrier penetration, superparamagnetic iron oxide nanoparticles, curcumin, click chemistry, targeted drug delivery, theranostics, orthotopic glioma model, intracranial tumors
MeSH terms
RAW 264.7 Cells, Animals, Brain Neoplasms, Curcumin, Female, Glioma, Humans, Mice, Inbred BALB C, Mice, Nude, Peptides, Reproducibility of Results, Neuropilin-1, Cell Line, Tumor, Mice, Kaplan-Meier Estimate, Exosomes, Magnetite Nanoparticles, Molecular Targeted Therapy

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