Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets
Open accessAbstract
The present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.31 ± 0.72) kg were randomly allotted into three treatments: (1) control, (2) infusing low SCFA, S1, (3) infusing high SCFA, S2. The experimental period lasted for 7 days. Gastric infusion of SCFA increased the concentrations of SCFA in serum and digesta, and enhanced the mRNA and protein abundances of SCFA receptors in pig intestine ( P < 0.05). Moreover, gastric infusion of SCFA led to alteration of intestinal morphology, elevation of intestinal development-related gene abundances, and decrease of apoptotic cell percentage, as well as reduction of pro-apoptosis gene and protein abundances ( P < 0.05). Besides, the jejunal SLC 7 A 1 and ileal DMT1 mRNA abundances in the SCFA infusion groups were higher than those in the control group ( P < 0.05). Additionally, gastric infusion of SCFA increased the mRNA abundances of Occludin and Claudin-1 in the duodenum and ileum, enhanced Lactobacillus spp counts in the ileal digesta, decreased the mRNA and protein abundances of IL-1β in the colon, and reduced Escherichia coli count in the ileal digesta ( P < 0.05). These data indicated that gastric infusion of SCFA, especially high SCFA concentration, may be beneficial to gut development of piglets via improving gut morphology, decreasing apoptotic cell percentage, and maintaining intestinal barrier function.
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Butyrate treatment resulted in downregulation of IL-1β levels, suggesting it may be beneficial for protection against inflammation-promoted barrier disruption.
“Moreover, butyrate treatment resulted in downregulation of IL-1β levels, suggesting it may be beneficial for protection against inflammation-promoted barrier disruption.87”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [87]
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Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
- Authors
- Diao, H., Jiao, A. R., Yu, B., Mao, X. B., & Chen, D. W.
- Affiliations
- Sichuan Agricultural University (CN)
- Corresponding author
- Mao, X. B.
- Chen, D. W.
- Venue
- Genes & Nutrition
- Published
- 2019-02-01
- Volume
- 14
- Issue
- 1
- Pages
- 4-4
- ISSN
- 1555-8932 (ISSN-L)
- 1865-3499
- PMC
- PMC6359775
- OpenAlex
- W2912903555
- Cited by
- 139
- References
- 55
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 28 · 2023: 12 · 2022: 20 · 2021: 16 · 2020: 20 · 2019: 4
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Genes & Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31672436)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- short-chain fatty acids, gastric infusion, intestinal barrier function, weaned piglets, intestinal development, intestinal morphology, apoptosis, tight junction proteins, occludin, claudin-1, SLC7A1, DMT1, Lactobacillus, Escherichia coli, IL-1β, ileal digesta
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