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Cited by 37Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentNosocomial Infections in ICU

Effects of omega-3 fatty acid nutrition on mortality in septic patients: a meta-analysis of randomized controlled trials

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Tao, Wei, Li, Ping-Song, Shen, Zhou, Shu, Yu-Sheng, Liu, Sen·2015·BMC Anesthesiology
DOI 10.1186/s12871-016-0200-7PMC PMC4950703
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Abstract

BACKGROUND: A previous systematic review and meta-analysis reported that omega-3 fatty acids nutrition may reduce mortality in septic patients. As new randomized controlled trials began to accumulate, we conducted an update. METHODS: A PubMed database was searched through Feb 2016, and randomized controlled trials comparing omega-3 fatty acids with control were selected by two reviewers independently. RESULTS: Eleven trials randomly assigning 808 patients were included in the present study. Using a fixed effects model, we found no significant effect of omega-3 fatty acids on overall mortality (risk ratio 0.84; 95 % confidence interval (CI): 0.67 to 1.05, P = 0.12), or infectious complications (risk ratio 0.95; 95 % CI: 0.72 to 1.25, P = 0.70). However, the duration of mechanical ventilation was markedly reduced by omega-3 fatty acids (weighted mean differences (WMD) = -3.82; 95 % CI: -4.61 to -3.04; P < 0.00001). A significant heterogeneity was found when the duration of hospital (I (2) = 93 %; WMD = -2.82; 95 % CI: -9.88 to 4.23, P = 0.43), or intensive care stay (I (2) = 87 %; WMD = -2.70; 95 % CI: -6.40 to 1.00, P = 0.15) were investigated. CONCLUSIONS: Omega-3 fatty acids confer no mortality benefit but are associated with a reduction in mechanical ventilation duration in septic patients. However, low sample size and heterogeneity of the cohorts included in this analysis limits the generalizability of our findings.

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  • Manzanares et al. and Zhu et al. also showed a decrease in infections.

    “Those of Palmer et al. (267), Chen et al. (268), Pradelli et al. (269), Manzanares et al. (270) and Zhu et al. (271) showed a decrease in length of stay, while Manzanares et al. (270) and Zhu et al. (271) also showed a decrease in infections.”

    From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [270]

    The Results section (page not specified) reports that omega-3 fatty acids did not reduce infectious complications in septic patients (risk ratio 0.95; 95% CI 0.72–1.25). The paper lists works by Manzanares and Zhu in its References but does not report that those works found fewer infections. (LLM, conf=0.84)

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  • In that meta-analysis, ω-3 PUFA recipients had a markedly reduced ventilation need.

    “However, ω-3 PUFA recipients had a markedly reduced ventilation need [64].”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [64]

    The Results section reports a marked reduction in the duration of mechanical ventilation among septic patients receiving omega-3 fatty acids, but it does not establish that fewer patients needed ventilation. The same section cautions that the duration finding was not robust in a sensitivity analysis. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • A meta-analysis of 11 RCTs in 808 septic patients found no significant effect of ω-3 PUFAs on overall mortality or infectious complications.

    “A meta-analysis of 11 randomized controlled trials (RCTs) in 808 septic patients found no significant effect of ω-3 PUFAs on overall mortality or infectious complications.”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [64]

  • Lu et al. and Manzanares et al. reported similar findings in other meta-analyses.

    “Lu et al (274) and Manzanares et al. (270) reported similar findings in other meta-analyses.”

    From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [270]

    The References list Manzanares meta-analyses, but our copy does not state their findings and does not identify a Lu meta-analysis. The Discussion says a previous meta-analysis found a mortality benefit inconsistent with this paper’s result, without identifying it as either named work. Searches for Lu, Manzanares, and similar meta-analysis findings did not establish the attributed comparison. (LLM, conf=0.76)

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Research works printed but not linked: 29

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Cited by

Sorted by citations

Authors
Tao, W., Li, P.-S., Shen, Z., Shu, Y.-S., & Liu, S.
Corresponding author
Liu, Sen
ORCID
Liu, Sen
Venue
BMC Anesthesiology
Publisher
Springer Science and Business Media LLC
Published
2015-12
Volume
16
Issue
1
Pages
39-39
ISSN
1471-2253 (ISSN-L)
DOI
10.1186/s12871-016-0200-7
PMC
PMC4950703
OpenAlex
W2485177285
Cited by
37
References
4
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 14 · 2019: 5 · 2018: 6 · 2017: 2 · 2014: 1
FWCI
0.34
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Anesthesiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords
omega-3 fatty acids, sepsis, mortality, mechanical ventilation duration, infectious complications, length of hospital stay, ICU length of stay, dietary supplementation
MeSH terms
Humans, Length of Stay, Respiration, Artificial, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Sepsis

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