Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis
Open accessAbstract
BACKGROUND: It is unclear if anaesthesia maintenance with propofol is advantageous or beneficial over inhalational agents. This study is intended to compare the effects of propofol vs. inhalational agents in maintaining general anaesthesia on patient-relevant outcomes and patient satisfaction. METHODS: Studies were identified by electronic database searches in PubMed™, EMBASE™ and the Cochrane™ library between 01/01/1985 and 01/08/2016. Randomized controlled trials (RCTs) of peer-reviewed journals were studied. Of 6688 studies identified, 229 RCTs were included with a total of 20,991 patients. Quality control, assessment of risk of bias, meta-bias, meta-regression and certainty in evidence were performed according to Cochrane. Common estimates were derived from fixed or random-effects models depending on the presence of heterogeneity. Post-operative nausea and vomiting (PONV) was the primary outcome. Post-operative pain, emergence agitation, time to recovery, hospital length of stay, post-anaesthetic shivering and haemodynamic instability were considered key secondary outcomes. RESULTS: The risk for PONV was lower with propofol than with inhalational agents (relative risk (RR) 0.61 [0.53, 0.69], p < 0.00001). Additionally, pain score after extubation and time in the post-operative anaesthesia care unit (PACU) were reduced with propofol (mean difference (MD) - 0.51 [- 0.81, - 0.20], p = 0.001; MD - 2.91 min [- 5.47, - 0.35], p = 0.03). In turn, time to respiratory recovery and tracheal extubation were longer with propofol than with inhalational agents (MD 0.82 min [0.20, 1.45], p = 0.01; MD 0.70 min [0.03, 1.38], p = 0.04, respectively). Notably, patient satisfaction, as reported by the number of satisfied patients and scores, was higher with propofol (RR 1.06 [1.01, 1.10], p = 0.02; MD 0.13 [0.00, 0.26], p = 0.05). Secondary analyses supported the primary results. CONCLUSIONS: Based on the present meta-analysis there are several advantages of anaesthesia maintenance with propofol over inhalational agents. While these benefits result in an increased patient satisfaction, the clinical and economic relevance of these findings still need to be addressed in adequately powered prospective clinical trials.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compared with inhalational anesthesia, TIVA reduces the risk of postoperative nausea and vomiting, pain scores after extubation, and duration of postoperative anesthesia care unit stay, but prolongs the time to respiratory recovery and tracheal extubation.
“Compared with inhalational anesthesia, TIVA reduces the risk of postoperative nausea and vomiting, pain scores after extubation, and duration of in postoperative anesthesia care unit stay; on the other hand, it prolongs the time to respiratory recovery and tracheal extubation.69”
From A call for immediate climate action in anesthesiology: routine use of minimal or metabolic fresh gas flow reduces our ecological footprint (2023) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · see citing works
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,759 · see citing works
Wan, X., Wang, W., Liu, J., & Tong, T. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-135 · Cited by 11,735 · see citing works
An estimation of the global volume of surgery: a modelling strategy based on available data
Weiser, T. G., Regenbogen, S. E., Thompson, K. D., Haynes, A. B., Lipsitz, S. R., Berry, W. R., & Gawande, A. A. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60878-8 · Cited by 2,517 · see citing works
A Factorial Trial of Six Interventions for the Prevention of Postoperative Nausea and Vomiting
Apfel, C. C., Korttila, K. T., Abdalla, M., Kerger, H., Turan, A., Vedder, I., Zernak, C., Danner, K., Jokela, R. M., Pocock, S., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032196 · Cited by 1,550 · see citing works
Consensus Guidelines for the Management of Postoperative Nausea and Vomiting
Gan, T. J., Diemunsch, P. A., Habib, A. S., Kovac, A. L., Kranke, P., Meyer, T. A., Watcha, M. F., Chung, F. F., Angus, S., Apfel, C. C., et al. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000002 · Cited by 1,483 · see citing works
Validity and reliability of a postoperative quality of recovery score: the QoR-40.
Myles, P., Weitkamp, B., Jones, K., Melick, J., & Hensen, S. (2000) · British Journal of Anaesthesia · doi:10.1093/oxfordjournals.bja.a013366 · Cited by 857 · see citing works
Pandit, J. J., Andrade, J., Bogod, D. G., Hitchman, J., Jonker, W. R., Lucas, N., Mackay, J. H., Nimmo, A., O'Connor, K., O’Sullivan, E., et al. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu313 · Cited by 549 · see citing works
Long-term Survival for Patients Undergoing Volatile versus IV Anesthesia for Cancer Surgery
Wigmore, T., Mohammed, K., & Jhanji, S. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000936 · Cited by 511 · see citing works
Murad, M. H., Montori, V. M., Ioannidis, J. P. A., Jaeschke, R., Devereaux, P. J., Prasad, K., Neumann, I., Carrasco-Labra, A., Agoritsas, T., Hatala, R., et al. (2014) · JAMA · doi:10.1001/jama.2014.5559 · Cited by 454 · see citing works
Subhypnotic Doses of Propofol Possess Direct Antiemetic Properties
Borgeat, A., Wilder‐Smith, O. H. G., le Saiah, M., & Rifat, K. (1992) · Anesthesia & Analgesia · doi:10.1213/00000539-199204000-00013 · Cited by 361 · see citing works
Tramèr, M. R., Moore, A., & McQuay, H. J. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/78.3.247 · Cited by 301 · see citing works
Shuster, J. J. (2011) · Research Synthesis Methods · doi:10.1002/jrsm.38 · Cited by 297 · see citing works
Kleif, J., Waage, J., Christensen, K. B., & Gögenür, I. (2017) · British Journal of Anaesthesia · doi:10.1016/j.bja.2017.11.013 · Cited by 291 · see citing works
Walker, E. M. K., Bell, M., Cook, T. M., Grocott, M. P. W., & Moonesinghe, R. (2016) · British Journal of Anaesthesia · doi:10.1093/bja/aew381 · Cited by 288 · see citing works
Landoni, G., Greco, T., Biondi‐Zoccai, G., Neto, C. N., Febres, D., Pintaudi, M., Pasin, L., Cabrini, L., Finco, G., & Zangrillo, A. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet231 · Cited by 185 · see citing works
Uhlig, C., Bluth, T., Schwarz, K., Deckert, S., Heinrich, L., Hert, S. G. D., Landoni, G., Neto, A. S., Schultz, M. J., Pelosi, P. P., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001120 · Cited by 179 · see citing works
Hert, S. G. D., Vlasselaers, D., Barbé, R., Ory, J., Dekegel, D., Donnadonni, R., Demeere, J. L., Mulier, J. P., & Wouters, P. F. (2009) · Anaesthesia · doi:10.1111/j.1365-2044.2009.06008.x · Cited by 169 · see citing works
Kumar, G., Stendall, C., Mistry, R., Gurusamy, K. S., & Walker, D. A. (2014) · Anaesthesia · doi:10.1111/anae.12713 · Cited by 156 · see citing works
Lee, W., Kim, M.-S., Kang, S.-W., Kim, S., & Lee, J.-R. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aeu405 · Cited by 147 · see citing works
Cheng, S., Yeh, J. T., & Flood, P. D. (2008) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000287653.77372.d9 · Cited by 138 · see citing works
Jellish, W. S., Lien, C. A., Fontenot, H. J., & Hall, R. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199603000-00009 · Cited by 136 · see citing works
Buse, G. L., Schumacher, P., Seeberger, E. E., Studer, W., Schuman, R. M., Faßl, J., Kasper, J., Filipovic, M., Bolliger, D., & Seeberger, M. D. (2012) · Circulation · doi:10.1161/circulationaha.112.126144 · Cited by 135 · see citing works
Seitz, D. P., Shah, P. S., Herrmann, N., Beyene, J., & Siddiqui, N. T. (2011) · BMC Geriatrics · doi:10.1186/1471-2318-11-83 · Cited by 131 · see citing works
Shin, S.-W., Cho, A.-R., Lee, H., Kim, H.-J., Byeon, G., Yoon, J.-W., Kim, K.-H., & Kwon, J. Y. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq257 · Cited by 127 · see citing works
Chui, J., Mariappan, R., Mehta, J., Manninen, P. H., & Venkatraghavan, L. (2014) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-014-0118-9 · Cited by 126 · see citing works
Hofer, C. K., Zollinger, A., Bu¨chi, S., Klaghofer, R., Serafino, D., Bühlmann, S., Buddeberg, C., Pasch, T., & Spahn, D. R. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg243 · Cited by 124 · see citing works
Peng, K., Liu, H., Wu, S.-R., Liu, H., Zhang, Z.-C., & Ji, F. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001504 · Cited by 86 · see citing works
Cai, Y., Hu, H., Liu, P., Feng, G., Dong, W., Yu, B., Zhu, Y., Song, J.-X., & Zhao, M. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31823da7a2 · Cited by 81 · see citing works
Qiu, Q., Choi, S. W., Wong, S. S. C., Irwin, M. G., & Cheung, C. W. (2016) · Anaesthesia · doi:10.1111/anae.13578 · Cited by 77 · see citing works
Hedin, R. J., Umberham, B. A., Detweiler, B., Kollmorgen, L., & Vassar, M. B. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001452 · Cited by 76 · see citing works
Meta-analysis of the cardioprotective effect of sevoflurane versus propofol during cardiac surgery
Li, F., & Yuan, Y. (2015) · BMC Anesthesiology · doi:10.1186/s12871-015-0107-8 · Cited by 75 · see citing works
Predictors of patient satisfaction with anaesthesia and surgery care
Royse, C. F., Chung, F. F., Newman, S. P., Stygall, J., & Wilkinson, D. J. (2012) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e328357e584 · Cited by 73 · see citing works
Hopewell, S., Boutron, I., Altman, D. G., & Ravaud, P. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003342 · Cited by 66 · see citing works
Landoni, G., Guarracino, F., Cariello, C., Franco, A., Baldassarri, R., Borghi, G., Covello, R. D., Gerli, C., Crivellari, M., & Zangrillo, A. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu290 · Cited by 64 · see citing works
Herling, S. F., Dreijer, B., Lam, G. W., Thomsen, T., & Møller, A. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011387.pub2 · Cited by 62 · see citing works
Systematic Reviews and Meta-Analyses of Randomized Controlled Trials on Perioperative Outcomes
Kehlet, H., & Joshi, G. P. (2015) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000687 · Cited by 58 · see citing works
White, P. F., & Warner, D. S. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31818ddba8 · Cited by 44 · see citing works
Detweiler, B., Kollmorgen, L., Umberham, B. A., Hedin, R. J., & Vassar, M. B. (2016) · Anaesthesia · doi:10.1111/anae.13520 · Cited by 40 · see citing works
Berning, V., Laupheimer, M., Nübling, M., & Heidegger, T. (2017) · Anaesthesia · doi:10.1111/anae.13906 · Cited by 40 · see citing works
Does Propofol Anesthesia Lead to Less Postoperative Pain Compared With Inhalational Anesthesia?
Peng, K., Liu, H. Y., Wu, S. R., Liu, H., Zhang, Z. C., & Ji, F. (2017) · Survey of Anesthesiology · doi:10.1097/01.sa.0000515466.89182.ca · Cited by 38 · see citing works
Propofol and survival: a meta‐analysis of randomized clinical trials
Pasin, L., Landoni, G., Cabrini, L., Borghi, G., Taddeo, D., Saleh, O., Greco, T., Monti, G., Chiesa, R., & Zangrillo, A. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12415 · Cited by 29 · see citing works
Kortekaas, K. A., van der Baan, A., Aarts, L. P. H. J., Palmen, M., Cobbaert, C. M., Verhagen, J. C. M., Engbers, F. H. M., Klautz, R. J. M., & Lindeman, J. H. N. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aet588 · Cited by 25 · see citing works
Yamamoto, N., Arima, H., Sugiura, T., Hirate, H., Taniura, H., Suzuki, K., & Sobue, K. (2013) · Anesthesiology · doi:10.1097/aln.0b013e31828afc16 · Cited by 21 · see citing works
Takechi, K., Carstens, M. I., Klein, A. H., & Carstens, E. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31827f560d · Cited by 19 · see citing works
Chui, J., Mehta, J., & Venkatraghavan, L. (2014) · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 52 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting
Gan, T. J., Belani, K. G., Bergese, S. D., Chung, F. F., Diemunsch, P. A., Habib, A. S., Jin, Z., Kovac, A. L., Meyer, T. A., Urman, R. D., et al. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004833 · Cited by 1,307 · see citing works
The Surgical Stress Response and Anesthesia: A Narrative Review
Ivaşcu, R., Torsin, L. I., Hostiuc, L., Niţipir, C., Corneci, D. E., & Duţu, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13103017 · Cited by 178 · see citing works
Irani, J., Hedrick, T. L., Miller, T. E., Lee, L., Steinhagen, E. F., Shogan, B. D., Goldberg, J. E., Feingold, D. L., Lightner, A. L., & Paquette, I. M. (2022) · Surgical Endoscopy · doi:10.1007/s00464-022-09758-x · Cited by 140 · see citing works
Irani, J., Hedrick, T., Miller, T., Lee, L., Steinhagen, E., Shogan, B., Goldberg, J., Feingold, D., Lightner, A., & Paquette, I. M. (2022) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000002650 · Cited by 71 · see citing works
Jin, Z., Gan, T. J., & Bergese, S. D. (2020) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s256234 · Cited by 95 · see citing works
Irwin, M. G., Chung, C. K. E., Ip, K. Y., & Wiles, M. D. (2020) · Anaesthesia · doi:10.1111/anae.14905 · Cited by 87 · see citing works
Postoperative Nausea and Vomiting in Pediatric Patients
Kovac, A. L. (2020) · Pediatric Drugs · doi:10.1007/s40272-020-00424-0 · Cited by 85 · see citing works
Kampman, J. M., Hermanides, J., Hollmann, M. W., Gilhuis, C. N., Bloem, W. A., Schraag, S., Pradelli, L., Repping, S., & Weiland, N. H. S. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102636 · Cited by 74 · see citing works
Self-citationManagement of postoperative nausea and vomiting in adults: current controversies
Rajan, N., & Joshi, G. P. (2021) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001063 · Cited by 66 · see citing works
Hari, Y., Satomi, S., Murakami, C., Narasaki, S., Morio, A., Kato, T., Tsutsumi, Y. M., Kakuta, N., & Tanaka, K. (2022) · Journal of Anesthesia · doi:10.1007/s00540-022-03041-y · Cited by 56 · see citing works
Cui, Y., Li, G., Cao, R., Luan, L., & Kla, K. M. (2019) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2019.06.028 · Cited by 59 · see citing works
Abandoning inhalational anaesthesia
White, S. M., & Shelton, C. L. (2020) · Anaesthesia · doi:10.1111/anae.14853 · Cited by 51 · see citing works
Enhanced Recovery Programs in an Ambulatory Surgical Oncology Center
Afonso, A. M., McCormick, P. J., Assel, M. J., Rieth, E. F., Barnett, K. M., Tokita, H. K., Masson, G., Laudone, V. P., Simon, B. A., & Twersky, R. S. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005356 · Cited by 47 · see citing works
Niu, Z., Gao, X., Shi, Z., Liu, T., Wang, M., Guo, L., & Qi, D. (2021) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2021.110374 · Cited by 46 · see citing works
Hughes, M., Culpin, E., Darley, R., McKinlay, J., Nix, P., Smedley, A., Tyagi, A. K., Sheikh, A., & Phillips, N. I. (2020) · Acta Neurochirurgica · doi:10.1007/s00701-020-04282-0 · Cited by 44 · see citing works
Anesthetic Approaches and Their Impact on Cancer Recurrence and Metastasis: A Comprehensive Review
Choi, H., & Hwang, W. (2024) · Cancers · doi:10.3390/cancers16244269 · Cited by 43 · see citing works
Kampmeier, T., Rehberg, S. W., Alsaleh, A. J. O., Schraag, S., Pham, J., & Westphal, M. (2021) · Value in Health · doi:10.1016/j.jval.2021.01.008 · Cited by 40 · see citing works
Self-citationRübsam, M.-L., Kruse, P., Dietzler, Y., Kropf, M., Bette, B., Zarbock, A., Kim, S.-C., & Hönemann, C. (2023) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/s12630-022-02393-z · Cited by 39 · see citing works
“Compared with inhalational anesthesia, TIVA reduces the risk of postoperative nausea and vomiting, pain scores after extubation, and duration of in postoperative anesthesia care unit stay; on the other hand, it prolongs the time to respiratory recovery and tracheal extubation.(69) Nevertheless, performing TIVA instead…”
BackgroundEnhanced recovery protocols for ambulatory surgery
Cukierman, D. S., Cata, J. P., & Gan, T. J. (2023) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2023.04.007 · Cited by 39 · see citing works
Licina, A., Silvers, A. J., Laughlin, H., Russell, J. H., & Wan, C. (2021) · BMC Anesthesiology · doi:10.1186/s12871-021-01281-1 · Cited by 38 · see citing works
Talıh, G., Yüksek, A., & Şahin, E. (2020) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102387 · Cited by 38 · see citing works
Shin, S., Kim, S. H., Park, K. K., Kim, S. J., Bae, J. C., & Choi, Y. S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061605 · Cited by 36 · see citing works
Ludwig, K. K., Wexelman, B. A., Chen, S., Cheng, G. S., DeSnyder, S. M., Golesorkhi, N., Greenup, R. A., James, T. A., Lee, B. T., Pockaj, B. A., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-11799-4 · Cited by 35 · see citing works
Adverse respiratory events with sevoflurane compared with desflurane in ambulatory surgery
Chen, W.-S., Chiang, M., Hung, K., Lin, K.-L., Wang, C., Poon, Y., Luo, S., & Wu, S. (2020) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001375 · Cited by 34 · see citing works
Wilent, W. B., Tesdahl, E. A., Trott, J., Tassone, S., Harrop, J. S., Klineberg, E. O., & Sestokas, A. K. (2021) · The Spine Journal · doi:10.1016/j.spinee.2021.07.002 · Cited by 32 · see citing works
Guidelines on perioperative optimization protocol for the adult patient 2023
Bloc, S., Alfonsi, P., Belbachir, A., Beaussier, M., Bouvet, L., Campard, S., Campion, S., Cazenave, L., Diemunsch, P. A., Maria, S. D., et al. (2023) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2023.101264 · Cited by 31 · see citing works
Pennington, B. R. T., Politi, M. C., Abdallah, A. B., Janda, A. M., Eshun-Wilsonova, I., deBourbon, N. G., Siderowf, L., Klosterman, H., Kheterpal, S., & Avidan, M. S. (2023) · BMC Anesthesiology · doi:10.1186/s12871-023-02219-5 · Cited by 30 · see citing works
Daccache, N., Wu, Y., Jeffries, S. D., Zako, J., Harutyunyan, R., Pelletier, E. D., Langlois, P. L., & Hemmerling, T. M. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.02.007 · Cited by 28 · see citing works
Propofol use in newborns and children: is it safe? A systematic review
Filho, E. M., & Riechelmann, M. B. (2020) · Jornal de Pediatria · doi:10.1016/j.jped.2019.08.011 · Cited by 27 · see citing works
Tang, L., Sun, Y., Hao, X., Sun, X., Xie, C., Wang, T., Hu, C., Lu, Y., & Liu, X.-S. (2023) · BJA Open · doi:10.1016/j.bjao.2023.100237 · Cited by 22 · see citing works
Yalcin, E. K., Kim, D. D., Mao, G., Rivas, E., Markwei, M. T., Chahar, P., Keebler, A., Cywiński, J. B., Kurz, A. M., & Turan, A. (2022) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2022.110672 · Cited by 24 · see citing works
General anesthesia during atrial fibrillation ablation: Standardized protocol and experience
Osorio, J., Rajendra, A. B., Varley, A. L., Henry, R., Cunningham, J., Spear, W., & MORALES, G. X. (2020) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13928 · Cited by 24 · see citing works
Li, X., Yu, L., Yang, J., & Tan, H. (2019) · BMC Anesthesiology · doi:10.1186/s12871-019-0835-2 · Cited by 23 · see citing works
de Carli, D., Meletti, J. F. A., Neto, N. E. U., Martinez, G. A., Kim, A. L. C., & de Camargo, R. P. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228805 · Cited by 23 · see citing works
Filum terminale lipomas—the role of intraoperative neuromonitoring
Srinivasan, H. L., Barrera, P. V., Agur, A., Soleman, J., Ekstein, M. P., Korn, A., Vendrov, I., Roth, J., & Constantini, S. (2020) · Child s Nervous System · doi:10.1007/s00381-020-04856-4 · Cited by 22 · see citing works
Anesthetic considerations for functional endoscopic sinus surgery: a narrative review
Saxena, A. R., & Nekhendzy, V. (2020) · Journal of Head & Neck Anesthesia · doi:10.1097/hn9.0000000000000025 · Cited by 21 · see citing works
Zheng, V., Wee, I., Abdullah, H., Tan, S., Tan, E., & Seow-En, I. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04408-7 · Cited by 20 · see citing works
Cost of Total Intravenous Anesthesia Versus Inhalation Anesthesia in Obstructive Sleep Apnea Surgery
Alnemri, A. E., Sussman, S. M., Estephan, L. E., Hamilton, C., Stewart, M., Zhan, T., Thaler, A., Ananth, A., Boon, M. S., Huntley, C. T., et al. (2022) · The Laryngoscope · doi:10.1002/lary.30094 · Cited by 20 · see citing works
The role of NMDARs in the anesthetic and antidepressant effects of ketamine
Zhou, L., & Duan, J. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14464 · Cited by 17 · see citing works
Guasch, E., Gómez, R., Brogly, N., & Gilsanz, F. (2019) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000715 · Cited by 17 · see citing works
Kim, D., Min, K. T., Kim, E. H., Choi, Y. S., & Choi, S. H. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.72758 · Cited by 16 · see citing works
Recommendation for the practice of total intravenous anesthesia
Obara, S., Kamata, K., Nakao, M., Yamaguchi, S., & Kiyama, S. (2024) · Journal of Anesthesia · doi:10.1007/s00540-024-03398-2 · Cited by 16 · see citing works
Total Intravenous Anesthesia for the Small Animal Critical Patient
Raffe, M. R. (2020) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2020.07.007 · Cited by 16 · see citing works
On the horns of a dilemma: choosing total intravenous anaesthesia or volatile anaesthesia
Riedel, B., Dubowitz, J. A., Yeung, J., Jhanji, S., Kheterpal, S., & Avidan, M. S. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.06.008 · Cited by 16 · see citing works
Luo, J., Xie, C., & Fan, D. (2025) · Pediatric Anesthesia · doi:10.1111/pan.15078 · Cited by 15 · see citing works
Ambulatory anesthesia and discharge: an update around guidelines and trends
Rohi, A., Olofsson, M. E. T., & Jakobsson, J. (2022) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001194 · Cited by 15 · see citing works
Aghababaie, Z., Wang, T. H., Nisbet, L. A., Matthee, A., Dowrick, J. M., Sands, G. B., Paskaranandavadivel, N., Cheng, L. K., O’Grady, G., & Angeli, T. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-38612-w · Cited by 15 · see citing works
Šprung, J., Deljou, A., Schroeder, D. R., Warner, D. O., & Weingarten, T. N. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006906 · Cited by 15 · see citing works
Jo, J.-Y., Kim, Y. J., Choi, S.-S., Park, J.-H., Park, H., & Hahm, K. (2021) · Pain Research and Management · doi:10.1155/2021/8876906 · Cited by 15 · see citing works
Sethi, N., Dutta, A., Puri, G. D., Sood, J., Choudhary, P. K., Gupta, M., Panday, B. C., & Malhotra, S. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006849 · Cited by 14 · see citing works
Management of anesthesia for procedures in the cardiac electrophysiology laboratory
Rajagopalan, B., Lakkireddy, D., Al‐Ahmad, A., Chrispin, J., Cohen, M. I., Biase, L. D., Gopinathannair, R., Nasr, V. G., Navara, R., Patel, P. J., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.06.048 · Cited by 14 · see citing works
Flamée, P., Viaene, K., Tosi, M., Carvalho, H. N., de Asmundis, C., Forget, P., & Poelaert, J. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005540 · Cited by 13 · see citing works
Pennington, B. R. T., Colquhoun, D. A., Neuman, M. D., Politi, M. C., Janda, A. M., Spino, C., Thelen-Perry, S., Wu, Z., Kumar, S. S., Gregory, S. H., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-070096 · Cited by 13 · see citing works
Hung, K.-C., Wang, W.-T., Liu, W.-C., Hsu, C.-W., Huang, Y.-T., Wu, J.-Y., & Chen, I.-W. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02660-8 · Cited by 14 · see citing works
Reduced Recovery Times with Total Intravenous Anesthesia in Patients with Obstructive Sleep Apnea
Stewart, M., Estephan, L. E., Thaler, A., Zhan, T., Connors, K., Malkani, K. V., Hunt, P., Boon, M. S., & Huntley, C. T. (2020) · The Laryngoscope · doi:10.1002/lary.29216 · Cited by 13 · see citing works
Lost in the Ether: The Environmental Impact of Anesthesia
Herr, M. M., Outterson, R. E., & Aggarwal, S. (2022) · Operative Techniques in Orthopaedics · doi:10.1016/j.oto.2022.100997 · Cited by 14 · see citing works
Total intravenous anaesthesia in ambulatory care
McIlroy, E., & Leslie, K. (2019) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000786 · Cited by 13 · see citing works
Drugs in anesthesia: preventing postoperative nausea and vomiting
Schlesinger, T., Weibel, S., Meybohm, P., & Kranke, P. (2021) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001010 · Cited by 13 · see citing works
Flexman, A. M., Wang, T., & Meng, L. (2019) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000747 · Cited by 12 · see citing works
Zhang, W., Wang, R., Li, B., Zhao, Y., Liu, X., & Yuan, J. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.863249 · Cited by 12 · see citing works
Radtke, L. E., Blackburn, B. E., Kapron, C. R., Erickson, J. A., Meier, A. W., Anderson, L. A., Gililland, J. M., Archibeck, M. J., & Pelt, C. E. (2024) · The Journal of Arthroplasty · doi:10.1016/j.arth.2024.01.027 · Cited by 11 · see citing works
Kim, S. H., Ju, H. M., Choi, C., Park, H. R., & Shin, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247089 · Cited by 11 · see citing works
Lee, J., Han, D.-W., Song, Y., Lee, J., Jeon, S., & Kim, M. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14040382 · Cited by 8 · see citing works
Stjernberg, M., Schlichting, E., Rustøen, T., Valeberg, B. T., Småstuen, M. C., & Raeder, J. C. (2021) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.14015 · Cited by 11 · see citing works
Raeder, J. C. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000922 · Cited by 10 · see citing works
Lehmann, F., Mader, J., Koch, C., Markmann, M., Leicht, D., & Sander, M. (2025) · BMC Anesthesiology · doi:10.1186/s12871-025-02982-7 · Cited by 9 · see citing works
de Carli, D., Meletti, J. F. A., de Camargo, R. P. S., Gratacós, L. S., Gomes, V. C. R., & Marques, N. D. (2021) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2021.01.013 · Cited by 9 · see citing works
Estephan, L. E., Sussman, S. M., Stewart, M., Zhan, T., Thaler, A., Boon, M. S., Hunt, P., & Huntley, C. T. (2022) · The Laryngoscope · doi:10.1002/lary.30438 · Cited by 10 · see citing works
Anaesthetic gases and the environment: Is it time for a rethink?
O'Brien, O., & Conlon, N. P. (2024) · The Surgeon · doi:10.1016/j.surge.2024.04.014 · Cited by 9 · see citing works
Kaur, G., Kaur, P., Gupta, R., Kullar, K. K., Bhangu, G. S., & Sandhu, S. S. (2021) · Indian Journal of Anaesthesia · doi:10.4103/ija.ija_998_20 · Cited by 9 · see citing works
High turnover for ambulatory orthopedic surgery
Shariat, A. N., Marcus, B., & Latmore, M. (2021) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001045 · Cited by 9 · see citing works
Yeung, J., Jhanji, S., Braun, J., Dunn, J., Eggleston, L., Frempong, S., Hiller, L., Jacques, C., Jefford, M. L., Mason, J. M., et al. (2024) · Trials · doi:10.1186/s13063-024-08159-w · Cited by 8 · see citing works
Beyond the Operating Room: A Narrative Review of Enhanced Recovery Strategies in Colorectal Surgery
Albalawi, H. I., Alyoubi, R., Alsuhaymi, N. M., Aldossary, F. A., Alkathiry Abdulrahman Mohammed, G., Albishi, F., Aljeddawi, J., Najm, F., Najem, N. A., & Almarhoon, M. M. A. (2024) · Cureus · doi:10.7759/cureus.76123 · Cited by 9 · see citing works
Hasegawa, H., Abe, A., Hayashi, H., Furuta, H., & Ishihama, T. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01481-8 · Cited by 8 · see citing works
Oxford guidelines for adult day-case tonsillectomy
Chaidas, K., & Winterborn, C. (2021) · Journal of Perioperative Practice · doi:10.1177/17504589211031067 · Cited by 8 · see citing works
Aditianingsih, D., Sukmono, R. B., Agung, T. A., Kartolo, W. Y., ADIWONGSO, E. S., & Mochtar, C. A. (2019) · Anesthesiology Research and Practice · doi:10.1155/2019/5629371 · Cited by 8 · see citing works
Jin, Z., Zhu, M., Gupta, A., Page, C. R., Gan, T. J., & Bergese, S. D. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1982893 · Cited by 8 · see citing works
Feng, Y., Xu, J., Ma, H., Wang, E., Bian, J., Fang, X., Shen, L., Zhu, T., Liu, K., Jiang, L., et al. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.09.038 · Cited by 7 · see citing works
Environmental Externalities of Switching From Inhalational to Total Intravenous Anesthesia
Kostrubiak, M., Johns, Z. R., Vatovec, C. M., Malgeri, M. P., & Tsai, M. H. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005448 · Cited by 7 · see citing works
Li, J., Zhou, D., Jin, Y., Zhou, H.-S., Fang, C., Zhu, Z.-Q., & Xiong, L. (2021) · Ibrain · doi:10.1002/j.2769-2795.2021.tb00081.x · Cited by 7 · see citing works
Yoon, H., Joo, S., Yoon, S., Seo, J., Kim, W. H., & Lee, H. (2023) · Korean Journal of Anesthesiology · doi:10.4097/kja.23083 · Cited by 7 · see citing works
Ovechkin, A. M., Евгеньевич, П. М., Sokologorskiy, S. V., & Evsyukova, M. A. (2021) · Russian Journal of Anesthesiology and Reanimatology · doi:10.17116/anaesthesiology202105171 · Cited by 6 · see citing works
Schwer, C. I., Roth, T., Gass, M., Rothweiler, R. M., Loop, T., Metzger, M. C., & Kalbhenn, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133829 · Cited by 6 · see citing works
Kamei, N., Higo, S., Mizuno, T., Mori, K., Sakamoto, A., & Ozawa, H. (2022) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.21-00091 · Cited by 6 · see citing works
Shirozu, K., Umehara, K., Ikeda, M., Kammura, Y., & Yamaura, K. (2020) · Journal of Anesthesia · doi:10.1007/s00540-020-02763-1 · Cited by 6 · see citing works
Barrera, A., & Zhu, V. (2025) · Aesthetic Plastic Surgery · doi:10.1007/s00266-024-04650-6 · Cited by 5 · see citing works
Verlis, K. M., Davies, J. F., McGain, F., Burch, H., Barratt, A. L., & Kazda, L. (2025) · The Medical Journal of Australia · doi:10.5694/mja2.70046 · Cited by 5 · see citing works
Hu, J. T., Wang, Z., Ma, B., Wang, T., Wang, E., & Yu, W. (2025) · Journal of Anesthesia and Translational Medicine · doi:10.1016/j.jatmed.2025.12.002 · Cited by 11 · see citing works
Anesthetic Management of Asleep and Awake Craniotomy for Supratentorial Tumor Resection
Xu, Y., & Vagnerova, K. (2021) · Anesthesiology Clinics · doi:10.1016/j.anclin.2020.11.007 · Cited by 5 · see citing works
Recovery Benefit With Total Intravenous Anesthesia in Patients Receiving Rhinoplasty
Sagalow, E. S., Estephan, L. E., Kumar, A., Hwang, M. S., Krein, H. D., & Heffelfinger, R. N. (2023) · Otolaryngology · doi:10.1002/ohn.319 · Cited by 5 · see citing works
Cablay, K., Arney, L. A., Peterman, N. J., Yu-Shan, A. A., Smith, G. L., Kazemi, A., Joseph, J. A., & Tuttle, J. R. (2024) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.23.00954 · Cited by 5 · see citing works
Charbonneau, H., Mrozek, S., Pradère, B., Cornu, J., & Misraï, V. (2020) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2020.07.007 · Cited by 5 · see citing works
Kuroki, M., Suzuki, H., Kurota, M., Nakane, M., & Kawamae, K. (2021) · JA Clinical Reports · doi:10.1186/s40981-021-00449-5 · Cited by 4 · see citing works
Majumdar, J. R., Vertosick, E., Assel, M. J., Soeprono, M., Groeger, H., Marte, M., Lin, E., & Twersky, R. S. (2021) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2021.110419 · Cited by 5 · see citing works
Ambulatory surgery for cancer patients: current controversies and concerns
Guerra‐Londono, C. E., Kim, D., & Manotas, M. F. R. (2021) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001049 · Cited by 5 · see citing works
Shirozu, K., Nobukuni, K., Umehara, K., Nagamatsu, M., Higashi, M., & Yamaura, K. (2022) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2021.0029 · Cited by 5 · see citing works
Perioperative management and surgical field optimization in functional endoscopic sinus surgery
Stamenković, D., Ahmad, J. G., Corso, R. M., Unic-Stojanovic, D. R., Radabaugh, J. P., Citardi, M. J., & Cattano, D. (2023) · Minerva Anestesiologica · doi:10.23736/s0375-9393.22.16887-2 · Cited by 5 · see citing works
Murakami, Y., Ueki, R., Tachikawa, T., & Hirose, M. (2019) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.89417 · Cited by 5 · see citing works
Veterinary anesthesia: an opportunity to reduce the environmental footprint of clinical care
Viola, L., Quintana, J., Sanchez, V., Scott, D., Griffenhagen, G. M., & Duncan, C. (2024) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.24.01.0059 · Cited by 4 · see citing works
Total intravenous anesthesia for liver resections: anesthetic implications and safety
Tan, S. Y. L., & Hwang, N. C. (2022) · Korean Journal of Anesthesiology · doi:10.4097/kja.22517 · Cited by 4 · see citing works
- Authors
- Schraag, S., Pradelli, L., Alsaleh, A. J. O., Bellone, M., Ghetti, G., Chung, T. L., Westphal, M., & Rehberg, S.
- Affiliations
- Golden Jubilee National Hospital (GB)
- Fresenius (Germany) (DE)
- University Hospital Münster (DE)
- Universitätsmedizin Greifswald (DE)
- Corresponding author
- Schraag, Stefan
- Venue
- BMC Anesthesiology
- Published
- 2018-11-08
- Volume
- 18
- Issue
- 1
- Pages
- 162-162
- ISSN
- 1471-2253 (ISSN-L)
- PMC
- PMC6225663
- OpenAlex
- W2899852599
- Cited by
- 194
- References
- 52
- Citations by year
- 2026: 25 · 2025: 23 · 2024: 29 · 2023: 21 · 2022: 25 · 2021: 38 · 2020: 25 · 2019: 8
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Anesthesiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fresenius Kabi (Not applicable)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Keywords
- propofol, inhalational anesthetics, postoperative nausea and vomiting, postoperative pain, emergence agitation, recovery time, extubation, patient satisfaction, outpatient surgery, inpatient surgery, hemodynamic instability, length of hospital stay, patient safety
- MeSH terms
- Ambulatory Surgical Procedures, Anesthesia, General, Hospitalization, Humans, Pain, Postoperative, Postoperative Pain, Propofol, Randomized Controlled Trials as Topic, Anesthetics, Inhalation, Anesthetics, Intravenous
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
