Measuring inter-rater reliability for nominal data – which coefficients and confidence intervals are appropriate?
Open accessAbstract
BACKGROUND: Reliability of measurements is a prerequisite of medical research. For nominal data, Fleiss' kappa (in the following labelled as Fleiss' K) and Krippendorff's alpha provide the highest flexibility of the available reliability measures with respect to number of raters and categories. Our aim was to investigate which measures and which confidence intervals provide the best statistical properties for the assessment of inter-rater reliability in different situations. METHODS: We performed a large simulation study to investigate the precision of the estimates for Fleiss' K and Krippendorff's alpha and to determine the empirical coverage probability of the corresponding confidence intervals (asymptotic for Fleiss' K and bootstrap for both measures). Furthermore, we compared measures and confidence intervals in a real world case study. RESULTS: Point estimates of Fleiss' K and Krippendorff's alpha did not differ from each other in all scenarios. In the case of missing data (completely at random), Krippendorff's alpha provided stable estimates, while the complete case analysis approach for Fleiss' K led to biased estimates. For shifted null hypotheses, the coverage probability of the asymptotic confidence interval for Fleiss' K was low, while the bootstrap confidence intervals for both measures provided a coverage probability close to the theoretical one. CONCLUSIONS: Fleiss' K and Krippendorff's alpha with bootstrap confidence intervals are equally suitable for the analysis of reliability of complete nominal data. The asymptotic confidence interval for Fleiss' K should not be used. In the case of missing data or data or higher than nominal order, Krippendorff's alpha is recommended. Together with this article, we provide an R-script for calculating Fleiss' K and Krippendorff's alpha and their corresponding bootstrap confidence intervals.
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The agreement on the eligibility of the included studies between the two authors resulted in a 0.78 kappa value.
“The agreement on the eligibility of the included studies, performed by the two authors (DB and DR), resulted in a 0.78 kappa value.23”
From Efficacy and safety of osteopathic manipulative treatment: an overview of systematic reviews (2022) · cites this paper as [23]
The Methods section explains that Fleiss’ K can measure agreement between two or more raters. The case-study Results concern breast-cancer assessments, not eligibility decisions by DB and DR. A search for the eligibility assessment and 0.78 found no passage reporting the claimed result. (LLM, conf=0.76)
Experimental — accuracy not yet measuredInter-rater agreement between the two overview authors on the ranking of quality achieved a 0.89 kappa value.
“Inter-rater agreement between the two overview authors (DB and FB) on the ranking of quality achieved a 0.89 kappa value.23”
From Efficacy and safety of osteopathic manipulative treatment: an overview of systematic reviews (2022) · cites this paper as [23]
The Methods discuss kappa as a measure of agreement, and the case-study Results report estimates for clinical measures, not quality rankings by overview authors. Searches for “0.89 kappa” and “ranking of quality” found no passage reporting the claimed agreement between DB and FB. (LLM, conf=0.77)
Experimental — accuracy not yet measured
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Efficacy and safety of osteopathic manipulative treatment: an overview of systematic reviews
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“The dataset contains 1,000 records annotated by three humans (Krippendorff’s 𝛼 of 0.88, 95% CI: 0.85, 0.90 [75]).”
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“Percentage agreement, Fleiss' kappa and its bootstrapped confidence interval were calculated in line with and utilizing R code provided by Zapf et al. (2016).”
Method
- Authors
- Zapf, A., Castell, S., Morawietz, L., & Karch, A.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Helmholtz Centre for Infection Research (DE)
- Klinikum Ernst von Bergmann (DE)
- German Center for Infection Research (DE)
- Corresponding author
- Zapf, Antonia
- Venue
- BMC Medical Research Methodology
- Published
- 2016-08-05
- Volume
- 16
- Issue
- 1
- Pages
- 93-93
- ISSN
- 1471-2288 (ISSN-L)
- PMC
- PMC4974794
- OpenAlex
- W2477907264
- Cited by
- 377
- References
- 9
- Citations by year
- 2026: 31 · 2025: 43 · 2024: 63 · 2023: 54 · 2022: 62 · 2021: 41 · 2020: 41 · 2019: 25 · 2018: 13 · 2017: 4
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Medical Research Methodology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- GRO (submittedVersion, cc-by)
- Funders
- Universiteit Maastricht
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Multidisciplinary Science and Engineering Research
- Keywords
- inter-rater reliability, Fleiss' kappa, Krippendorff's alpha, nominal data, confidence intervals, bootstrap confidence intervals, asymptotic confidence intervals, coverage probability, missing data, measurement reliability
- MeSH terms
- Algorithms, Breast Neoplasms, Data Interpretation, Statistical, Female, Humans, Retrospective Studies, Reproducibility of Results, Observer Variation, Confidence Intervals
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