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Cited by 42Cervical Cancer and HPV ResearchReproductive tract infections researchGenital Health and Disease

Epidemiologic characterization of human papillomavirus (HPV) infection in various regions of Yunnan Province of China

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Baloch, Zulqarnain, Li, Yuanyue, Yuan, Tao, Feng, Yue, Liu, Yanqing, Tai, Wenlin, Liu, Li, Wang, Binghui +3 more·2016·BMC Infectious Diseases
DOI 10.1186/s12879-016-1562-7PMC PMC4881205
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Abstract

BACKGROUND: This study was designed to determine the Human papillomavirus (HPV) prevalence and its distribution of genotypes in various regions of Yunnan Province, China. METHOD: In this study, participants were recruited during routine gynecologic examination between Oct 2013 and Feb 2015. A total of 17,898 women were recruited. Polymerase chain reaction was used for detecting the HPV positive samples and HPV geno-array test was used for genotyping. RESULTS: The overall HPV infection rate (19.9 %) among the south-western women was significantly higher (P = 0.001) than that among the north-western (18.0 %), south-eastern (13.3 %), north-eastern (11.1 %) and central women (12.9 %). The high-risk (HR) (18.1 %, P = 0.001) and single genotype (16.7 %, P = 0.001) infection rates among the South-western women were also significantly higher than those of among the north-western (13.9 %, 11.3 %), south-eastern (11.6 %, 10.5 %), north-eastern (9.6 %, 9.1 %) and central women (10.5 %, 10.0 %), respectively. While, the infections with multiple HPV (4.2 %) genotypes were significantly more common (P = 0.001) among women in north-western Yunnan than women in the south-western (1.3 %, 3.1 %), south-eastern (1.7 %, 2.7 %), north-eastern (1.5 %, 2.0 %) and central Yunnan (2.4 %, 2.9 %). A total of 30 HPV genotypes were detected; among them 13 were HR-HPV, 3 were PHR-HPV (Potential High risk), 8 were LR-HPV (Low risk) and six were unclassified. The most common HPV genotypes were HPV-52, 16, 58, 53 in control group, HPV-16, 52, 58, 39 and 53 in CINI (Cervical intraepithelial Neoplasia), HPV-52, 16, 58, 33, 53 and 81 in CINII, HPV16, 58, 18, 52, 81 in CINIII and HPV-16 18, 58, 52 in cervical cancer (CC), respectively. Such variation has also been observed about distribution of HPV genotypes distribution among single and multiple infections. CONCLUSION: This study gives an epidemiological estimate of HPV prevalence and different genotype distribution in various region of Yunnan province and further explains its prevalence in different neoplastic lesions. Overall HPV-16, 52, 58, and 18 are the leading HR-HPV genotypes.

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  • HPV infection at younger age reached its peak soon after sexual initiation.

    “HPV infection at younger age reached its peak soon after sexual initiation [28].”

    From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [28]

    The Results section (‘HPV genotypes and infection’; page unavailable) reports the highest overall HPV prevalence in women under 35, with prevalence declining thereafter, though it also notes a second peak in older women. The paper does not establish when those women initiated sexual activity, so it does not support the claim that the younger-age peak occurred soon after sexual initiation. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The bimodal shaped infection peak in noncancer cases is similar to many other reports.

    “The age-specific trend of HPV infection among noncancer cases showed bimodal shaped infection peak which is similar to many other reports [28].”

    From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [28]

    The Results section ('HPV genotypes and infection'; page unavailable) reports an early HPV-prevalence peak and a less pronounced second peak among women with normal results, supporting the bimodal pattern in noncancer cases. The passages found do not establish that this pattern is similar to many other reports. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Baloch, Z., Li, Y., Yuan, T., Feng, Y., Liu, Y., Tai, W., Liu, L., Wang, B., Zhang, A.-M., Wu, X., & Xia, X.
Affiliations
  • Kunming University of Science and Technology (CN)
  • First People's Hospital of Yunnan Province (CN)
Corresponding author
  • Wu, Xiaomei
  • Xia, Xueshan
ORCID
Venue
BMC Infectious Diseases
Publisher
Springer Science and Business Media LLC
Published
2016-05-26
Volume
16
Issue
1
Pages
228-228
ISSN
1471-2334 (ISSN-L)
DOI
10.1186/s12879-016-1562-7
PMC
PMC4881205
OpenAlex
W2402763821
Cited by
42
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 8 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 4
FWCI
5.63
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Infectious Diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81360247, 2014FB090)
  • the Key and New Product Development Project of Yunnan province (2013BC009)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Surgery › Genital Health and Disease
Keywords
human papillomavirus, HPV prevalence, HPV genotypes, regional variation, Yunnan, cervical intraepithelial neoplasia, high-risk HPV, multiple HPV genotypes, HPV16, HPV52, HPV58, HPV39, HPV53, cervical cancer, women's health, cervical cancer screening
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Uterine Cervical Dysplasia, China, Demography, Female, Genotype, Humans, Middle Aged, Women's Health Services, Prevalence, Polymerase Chain Reaction, Papillomaviridae, Papillomavirus Infections, Young Adult

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