The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: a systematic review and meta-analysis
Open accessAbstract
Background: Uropathogenic Escherichia coli (UPEC) are amongst the most frequent causes of urinary tract infections. We report a systematic review and meta-analysis of virulence factors and antimicrobial resistance of UPEC isolated from urinary tract infections. Methods: A systematic review and meta-analysis were performed using PRISMA guidelines (Research Registry ref. 5874). Data were extracted from PubMed/MEDLINE and ScienceDirect databases for studies published from January 1, 2000 to December 31, 2019. Studies reporting antimicrobial resistance and virulence factors of UPEC isolated in confirmed urinary tract infections (≥10 5 CFU/ml) were eligible. Prevalence of antimicrobial resistance and virulence factors of UPEC were estimated using random-effects meta-analysis model. Estimates with 95% confidence intervals, I-square ( I 2 ) statistic, and Cochran’s Q test were computed using the score statistic and the exact binomial method by incorporating the Freeman-Tukey double arcsine transformation of proportions. Results: Our search returned 2504 hits, of which 13 studies were included in the meta-analysis, totalling 1888 UPEC isolates. Highest antimicrobial resistance rates were observed among the antibiotic class of tetracycline in 69.1% (498/721), followed by sulphonamides in 59.3% (1119/1888), quinolones in 49.4% (1956/3956), and beta-lactams in 36.9% (4410/11964). Among beta-lactams, high resistance was observed in aminopenicillins in 74.3% (1157/1557) and first generation cephalosporins in 38.8% (370/953). Meanwhile, virulence factors with highest prevalence were immune suppressors (54.1%) followed by adhesins (45.9%). Taken individually, the most observed virulence genes were shiA (92.1%), CSH (80.0%), fimH/MSHA (75.3%), traT (75.1%), sisA (72.2%), iucD (65.7%), iutA (61.8%), kpsMTII (60.6%), and PAI (55.2%). Conclusions: The increased antibiotic resistance of UPEC isolates was demonstrated and suggested a need for reassessment of empirical therapies in urinary tract infections treatment caused by this pathogen. In addition, this pathotype exhibited diverse surface and secreted virulence factors.
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Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583 · cited 5×
“These allow UPEC to infect an immunocompetent host, as they encode for factors enabling it to colonize the periurethral area and ascend the urethra to the bladder [7].”
BackgroundInfluentialMetaprop: a Stata command to perform meta-analysis of binomial data
Nyaga, V. N., Arbyn, M., & Aerts, M. (2014) · Archives of Public Health · doi:10.1186/2049-3258-72-39 · Cited by 2,139
Hunter, J. P., Saratzis, A., Sutton, A. J., Boucher, R. H., Sayers, R. D., & Bown, M. J. (2014) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.03.003 · Cited by 786
Cited by
Urinary Tract Infections: The Current Scenario and Future Prospects
Mancuso, G., Midiri, A., Gerace, E., Marra, M., Zummo, S., & Biondo, C. (2023) · Pathogens · doi:10.3390/pathogens12040623 · Cited by 396
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics
Timm, M. R., Russell, S. K., & Hultgren, S. J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01092-4 · Cited by 190
Metadata
- Authors
- Bunduki, G. K., Heinz, E., Phiri, V. S., Noah, P., Feasey, N., & Musaya, J.
- Venue
- BMC Infectious Diseases
- Published
- 2021-08-04
- Volume
- 21
- Issue
- 1
- Pages
- 753-753
- ISSN
- 1471-2334 (ISSN-L)
- OpenAlex
- W3154232046
- Cited by
- 165
- References
- 3
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bunduki, G. K., Heinz, E., Phiri, V. S., Noah, P., Feasey, N., & Musaya, J. (2021). Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: a systematic review and meta-analysis. BMC Infectious Diseases. https://doi.org/10.1186/s12879-021-06435-7
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