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High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases

Suzuki, Shinsuke, Ichikawa, Yasushi, Nakagawa, Kazuya, Kumamoto, Takafumi, Mori, Ryutaro, Matsuyama, Ryusei, Takeda, Kazuhisa, Ota, Mitsuyoshi, Tanaka, Kuniya, Tamura, Tomohiko, Endo, Itaru·2015·BMC Cancer
DOI 10.1186/s12885-015-1863-zPMC PMC4632336
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Fig. 1 Representative immunohistochemical staining patterns of formalin-fixed, paraffin-embedded sections of colorectal liver metastases using monoclonal antibodies to (a) tryptase, (b) MAC387, (c) CD83, and (d) CD31. Original magnification, ×200. Scale bar, 50 μm
Fig. 1 Representative immunohistochemical staining patterns of formalin-fixed, paraffin-embedded sections of colorectal liver metastases using monoclonal antibodies to (a) tryptase, (b) MAC387, (c) CD83, and (d) CD31. Original magnification, ×200. Scale bar, 50 μmCC BY · PubMed Central
Fig. 2 Tissue samples from resected primary lesions were stained with monoclonal antibodies to tryptase. The log-rank test was used to compare the number of mast cells (MCs) in primary lesions and metastatic lesions. There was no correlation between these parameters (r = 0.04, p = 0.73)
Fig. 2 Tissue samples from resected primary lesions were stained with monoclonal antibodies to tryptase. The log-rank test was used to compare the number of mast cells (MCs) in primary lesions and metastatic lesions. There was no correlation between these parameters (r = 0.04, p = 0.73)CC BY · PubMed Central
Fig. 3 Tissue samples from resected metastatic lesions were stained with monoclonal antibodies to tryptase, MAC387 and CD83. (a, c, e) Disease-free survival (DFS) and (b, d, f) overall survival (OS) were determined using the Kaplan-Meier method, and the log-rank test was used to compare DFS and OS in groups with low and high numbers of peritumoral mast cells (MCs), peritumoral macrophages (Mφs) and peritumoral mature dendritic cells (DCs)
Fig. 3 Tissue samples from resected metastatic lesions were stained with monoclonal antibodies to tryptase, MAC387 and CD83. (a, c, e) Disease-free survival (DFS) and (b, d, f) overall survival (OS) were determined using the Kaplan-Meier method, and the log-rank test was used to compare DFS and OS in groups with low and high numbers of peritumoral mast cells (MCs), peritumoral macrophages (Mφs) and peritumoral mature dendritic cells (DCs)CC BY · PubMed Central

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Metadata

Authors
Suzuki, S., Ichikawa, Y., Nakagawa, K., Kumamoto, T., Mori, R., Matsuyama, R., Takeda, K., Ota, M., Tanaka, K., Tamura, T., & Endo, I.
Venue
BMC Cancer
Publisher
Springer Science and Business Media LLC
Published
2015-11-04
Volume
15
Issue
1
ISSN
1471-2407
DOI
10.1186/s12885-015-1863-z
PMC
PMC4632336
Cited by
42
References
0
Language
en
Licence
www.springer.com/tdm (unspecified)

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CoChat. (2026). Citation check: High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases. https://app.cochat.ai/papers/10.1186/s12885-015-1863-z
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Suzuki, S., Ichikawa, Y., Nakagawa, K., Kumamoto, T., Mori, R., Matsuyama, R., Takeda, K., Ota, M., Tanaka, K., Tamura, T., & Endo, I. (2015). High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases. BMC Cancer. https://doi.org/10.1186/s12885-015-1863-z