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Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer

Ma, Ying, Hwang, Rosa F., Logsdon, Craig D., Ullrich, Stephen E.·2013·Cancer Research
DOI 10.1158/0008-5472.can-12-4479PMC PMC3702652

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment, which includes cancer-associated fibroblasts [also known as pancreatic stellate cells (PSC)] and immune cells that provide a fibrotic niche that impedes successful cancer therapy. We have found that mast cells are essential for PDAC tumorigenesis. Whether mast cells contribute to the growth of PDAC and/or PSCs is unknown. Here, we tested the hypothesis that mast cells contribute to the growth of PSCs and tumor cells, thus contributing to PDAC development. Tumor cells promoted mast cell migration. Both tumor cells and PSCs stimulated mast cell activation. Conversely, mast cell–derived interleukin (IL)-13 and tryptase stimulated PSC proliferation. Treating tumor-bearing mice with agents that block mast cell migration and function depressed PDAC growth. Our findings suggest that mast cells exacerbate the cellular and extracellular dynamics of the tumor microenvironment found in PDAC. Therefore, targeting mast cells may inhibit stromal formation and improve therapy. Cancer Res; 73(13); 3927–37. ©2013 AACR.

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Research works printed but not linked: 49

  1. Fleshman, 2010, Pancreatic cancer: a rare tumor with a devastating health toll, Rare Tumors, 2, e52, 10.4081/rt.2010.e52 · DOI
  2. Chu, 2007, Stromal biology of pancreatic cancer, J Cell Biochem, 101, 887, 10.1002/jcb.21209 · DOI
  3. Neoptolemos, 2004, A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer, N Engl J Med, 350, 1200, 10.1056/NEJMoa032295 · DOI
  4. Olive, 2009, Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer, Science, 324, 1457, 10.1126/science.1171362 · DOI · Paper page
  5. Laheru, 2005, Immunotherapy for pancreatic cancer—science driving clinical progress, Nat Rev Cancer, 5, 459, 10.1038/nrc1630 · DOI
  6. Clark, 2007, Dynamics of the immune reaction to pancreatic cancer from inception to invasion, Cancer Res, 67, 9518, 10.1158/0008-5472.CAN-07-0175 · DOI · Paper page
  7. Yen, 2002, Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas, Surgery, 131, 129, 10.1067/msy.2002.119192 · DOI
  8. Hwang, 2008, Cancer-associated stromal fibroblasts promote pancreatic tumor progression, Cancer Res, 68, 918, 10.1158/0008-5472.CAN-07-5714 · DOI
  9. Neesse, 2011, Stromal biology and therapy in pancreatic cancer, Gut, 60, 861, 10.1136/gut.2010.226092 · DOI
  10. Provenzano, 2012, Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma, Cancer Cell, 21, 418, 10.1016/j.ccr.2012.01.007 · DOI · Paper page
  11. Jacobetz, 2013, Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer, Gut, 62, 112, 10.1136/gutjnl-2012-302529 · DOI · Paper page
  12. Apte, 2004, Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells, Pancreas, 29, 179, 10.1097/00006676-200410000-00002 · DOI · Paper page
  13. Xu, 2010, Role of pancreatic stellate cells in pancreatic cancer metastasis, Am J Pathol, 177, 2585, 10.2353/ajpath.2010.090899 · DOI
  14. Vonlaufen, 2008, Pancreatic stellate cells: partners in crime with pancreatic cancer cells, Cancer Res, 68, 2085, 10.1158/0008-5472.CAN-07-2477 · DOI
  15. Ribatti, 2009, The controversial role of mast cells in tumor growth, Int Rev Cell Mol Biol, 275, 89, 10.1016/S1937-6448(09)75004-X · DOI
  16. Choi, 1987, Mast cells, fibroblasts, and fibrosis. New clues to the riddle of mast cells, Immunol Res, 6, 145, 10.1007/BF02918088 · DOI
  17. Cai, 2010, Prognostic significance of mast cell count following curative resection for pancreatic ductal adenocarcinoma, Surgery, 149, 576, 10.1016/j.surg.2010.10.009 · DOI
  18. Strouch, 2010, Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression, Clin Cancer Res, 16, 2257, 10.1158/1078-0432.CCR-09-1230 · DOI
  19. Chang, 2011, Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma, Clin Cancer Res, 17, 7015, 10.1158/1078-0432.CCR-11-0607 · DOI
  20. Furukawa, 1996, Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16, Am J Pathol, 148, 1763
  21. Ouyang, 2000, Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype, Am J Pathol, 157, 1623, 10.1016/S0002-9440(10)64800-6 · DOI
  22. Butterfield, 1990, Purification of tryptase from a human mast cell line, J Leukoc Biol, 47, 409, 10.1002/jlb.47.5.409 · DOI
  23. Kirshenbaum, 2003, Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI, Leuk Res, 27, 677, 10.1016/S0145-2126(02)00343-0 · DOI
  24. Al-Nasiry, 2007, The use of Alamar Blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells, Hum Reprod, 22, 1304, 10.1093/humrep/dem011 · DOI
  25. Kitamura, 1989, Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin, J Cell Physiol, 140, 323, 10.1002/jcp.1041400219 · DOI
  26. Byrne, 2008, Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression, J Immunol, 180, 4648, 10.4049/jimmunol.180.7.4648 · DOI
  27. Corbett, 1984, Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice, Cancer Res, 44, 717
  28. Soucek, 2007, Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors, Nat Med, 13, 1211, 10.1038/nm1649 · DOI
  29. Rabinovich, 2008, Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer, Proc Natl Acad Sci U S A, 105, 14342, 10.1073/pnas.0804105105 · DOI
  30. Sillaber, 1993, Tumor necrosis factor alpha and interleukin-1 beta mRNA expression in HMC-1 cells: differential regulation of gene product expression by recombinant interleukin-4, Exp Hematol, 21, 1271
  31. Guhl, 2010, Mast cell lines HMC-1 and LAD2 in comparison with mature human skin mast cells—drastically reduced levels of tryptase and chymase in mast cell lines, Exp Dermatol, 19, 845, 10.1111/j.1600-0625.2010.01103.x · DOI
  32. Koibuchi, 1985, Histamine release induced from mast cells by active components of compound 48/80, Eur J Pharmacol, 115, 163, 10.1016/0014-2999(85)90687-9 · DOI
  33. Klein, 2006, Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines, J Immunol, 177, 6667, 10.4049/jimmunol.177.10.6667 · DOI
  34. Kelly-Welch, 2003, Interleukin-4 and interleukin-13 signaling connections maps, Science, 300, 1527, 10.1126/science.1085458 · DOI
  35. Laping, 2007, Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats, Clin Cancer Res, 13, 3087, 10.1158/1078-0432.CCR-06-1811 · DOI
  36. Shinozaki, 2010, IL-13 promotes the proliferation of rat pancreatic stellate cells through the suppression of NF-kappaB/TGF-beta1 pathway, Biochem Biophys Res Commun, 393, 61, 10.1016/j.bbrc.2010.01.078 · DOI
  37. Fichtner-Feigl, 2006, IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis, Nat Med, 12, 99, 10.1038/nm1332 · DOI
  38. Miller, 1990, Cloning and characterization of a second complementary DNA for human tryptase, J Clin Invest, 86, 864, 10.1172/JCI114786 · DOI
  39. Vanderslice, 1990, Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family, Proc Natl Acad Sci U S A, 87, 3811, 10.1073/pnas.87.10.3811 · DOI
  40. McLarty, 2011, Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts, Hypertension, 58, 264, 10.1161/HYPERTENSIONAHA.111.169417 · DOI
  41. Juremalm, 2000, The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1alpha acts as a mast cell chemotaxin, Eur J Immunol, 30, 3614, 10.1002/1521-4141(200012)30:12<3614::AID-IMMU3614>3.0.CO;2-B · DOI
  42. Hatse, 2002, Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4, FEBS Lett, 527, 255, 10.1016/S0014-5793(02)03143-5 · DOI
  43. Ahmed, 2009, Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study, Pathol Res Pract, 205, 634, 10.1016/j.prp.2009.04.003 · DOI
  44. Chiu, 2009, The stromal composition of mast cell aggregates in systemic mastocytosis, Mod Pathol, 22, 857, 10.1038/modpathol.2009.53 · DOI
  45. Saika, 2001, TGFbeta2 in corneal morphogenesis during mouse embryonic development, Dev Biol, 240, 419, 10.1006/dbio.2001.0480 · DOI
  46. Theoharides, 2008, Mast cells and pancreatic cancer, N Engl J Med, 358, 1860, 10.1056/NEJMcibr0801519 · DOI
  47. Li, 2012, SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway, Cancer Lett, 322, 169, 10.1016/j.canlet.2012.02.035 · DOI
  48. Palaniyandi Selvaraj, 2005, Involvement of mast cells in the development of fibrosis in rats with postmyocarditis dilated cardiomyopathy, Biol Pharm Bull, 28, 2128, 10.1248/bpb.28.2128 · DOI
  49. Kim, 2012, Plerixafor, a CXCR4 antagonist, mitigates skin radiation-induced injury in mice, Radiat Res, 178, 202, 10.1667/RR2886.1 · DOI

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Metadata

Authors
Ma, Y., Hwang, R. F., Logsdon, C. D., & Ullrich, S. E.
Affiliations
Authors' Affiliations: Departments of 1Immunology and the Center for Cancer Immunology Research, 2Surgical Oncology, 3Cancer Biology, and 4Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center; and 5The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2013-06-30
Volume
73
Issue
13
Pages
3927-3937
ISSN
  • 0008-5472
  • 1538-7445
DOI
10.1158/0008-5472.can-12-4479
PMC
PMC3702652
Cited by
186
References
6
Language
en

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CoChat. (2026). Citation check: Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer. https://app.cochat.ai/papers/10.1158/0008-5472.can-12-4479
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Ma, Y., Hwang, R. F., Logsdon, C. D., & Ullrich, S. E. (2013). Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer. Cancer Research. https://doi.org/10.1158/0008-5472.can-12-4479