The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Gut microbiome and its role in colorectal cancer
Open accessAbstract
Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies. The composition of bacterial strains and the influence of geography, race, sex, and diet on the composition of the microbiome serve as important information for screening, early detection and prediction of the treatment outcome of CRC. Microbiome modulation is one of the most prospective new strategies in medicine to improve the health of individuals. Therefore, future research and clinical trials on the gut microbiome in oncology as well as in the treatment of CRC patients are warranted to determine the efficacy of systemic treatments for CRC, minimize adverse effects and increase survival rates.
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Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
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Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
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“The relationship between the gut microbiome and the response to immunotherapy with checkpoint inhibitors has also been recognized in other types of cancer, such as melanoma, in which immunotherapy with checkpoint inhibitors is well established [42, 43].”
BackgroundCommensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
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The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
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“Different strains of bacteria are connected to different gastrointestinal (GI) tumours; for example, enterotoxigenic Bacteroides fragilis is connected to CRC [53, 54].”
BackgroundImmunotherapy in colorectal cancer: Rationale, challenges and potential
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The pros, cons, and many unknowns of probiotics
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The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
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“Toxic byproducts of microbial metabolism of such a diet, such as N-nitroso compounds and hydrogen sulfide, induce epithelial hyperproliferation by disrupting mucus barrier function [13, 19].”
Background
Cited by
PD-1 and PD-L1: architects of immune symphony and immunotherapy breakthroughs in cancer treatment
Parvez, A., Choudhary, F., Mudgal, P., Khan, R., Qureshi, K. A., Farooqi, H., & Aspatwar, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1296341 · Cited by 216
Van den Abbeele, P., Deyaert, S., Albers, R., Baudot, A., & Mercenier, A. (2023) · Nutrients · doi:10.3390/nu15092090 · Cited by 46
Said, S., & Ibrahim, W. (2025) · Cancer Management and Research · doi:10.2147/cmar.s405590 · Cited by 25
Cai, J.-A., Zhang, Y.-Z., Yu, E.-D., Ding, W.-Q., Jiang, Q.-W., Cai, Q.-C., & Zhong, L. (2023) · Nutrients · doi:10.3390/nu15132940 · Cited by 9
Metadata
- Authors
- Rebersek, M.
- Venue
- BMC Cancer
- Published
- 2021-12-11
- Volume
- 21
- Issue
- 1
- Pages
- 1325-1325
- ISSN
- 1471-2407 (ISSN-L)
- OpenAlex
- W4200287074
- Cited by
- 355
- References
- 23
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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