Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
Open accessAbstract
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia. METHOD: A retrospective study was carried out in seven hospitals having MDR-TB treatment center of Amhara region, Ethiopia from September 2015 to February 2018. An accelerated failure time and parametric shared frailty models were employed. RESULTS: The study revealed that the recovery time of MDR-TB patients in Amhara region was 21 months. Out of the total MDR-TB patients, 110 (35.4%) censored and 201 (64.6%) cured of MDR-TB. The clustering effect of frailty model was hospitals and the Weibull-gamma shared frailty model was selected among all and hence used for this study. The study showed that extra pulmonary MDR-TB patients had longer recovery time than that of seamier pulmonary MDR-TB patients in Amhara region, Ethiopia. According to this study, male MDR-TB patients, MDR-TB patients with co-morbidity and clinical complication were experiencing longer recovery time than that of the counter groups. This study also showed that MDR-TB patients with poor adherence had longer recovery time than those with good adherence MDR-TB patients. CONCLUSION: Among different factors considered in this study, MDR-TB type, clinical complication, adherence, co-morbidities, sex, and smoking status had a significant effect on recovery time of MDR-TB patients in Amhara region, Ethiopia. In conclusion, the Regional and Federal Government of Ethiopia should take immediate steps to address causes of recovery time of MDR-TB patients in Amhara region through encouraging adherence, early case detection, and proper handling of drug-susceptibility according to WHO guidelines.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Psychosocial problems are related to adherence to treatment programs in MDR-TB patients.
“Psychosocial problems are related to adherence to treatment programs, and thus, they affect the success and duration of the treatment program.”
From The effects of acceptance and commitment therapy on psychosocial impact and adherence of multidrug-resistant tuberculosis patients (2022) · cites this paper as [7]
The Discussion (page unavailable) reports that poor adherence was associated with longer recovery time in MDR-TB patients. It speculates that alcohol and drug abuse may be related to medication interruption, but does not establish that psychosocial problems generally are related to adherence or affect treatment success. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMDR-TB patients with non-adherence to treatment have longer treatment times than adherent clients.
“MDR-TB patients with non-adherence to treatment have longer treatment times than adherent clients.7”
From The effects of acceptance and commitment therapy on psychosocial impact and adherence of multidrug-resistant tuberculosis patients (2022) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new look at the statistical model identification
Akaike, H. (1974) · IEEE Transactions on Automatic Control · doi:10.1109/tac.1974.1100705 · Cited by 51,879 · see citing works
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297 · see citing works
Global tuberculosis report (2014)
Gabbasova, L. A., & Who, E. R. E. (2014) · Cited by 12,702 · see citing works
Local Polynomial Modelling and its Applications
Fan, J., & Gijbels, I. (1994) · Springer eBooks · doi:10.1007/978-1-4899-3150-4 · Cited by 2,897 · see citing works
Antibiotics and Bacterial Resistance in the 21st Century
Fair, R. J., & Tor, Y. (2014) · Perspectives in Medicinal Chemistry · doi:10.4137/pmc.s14459 · Cited by 1,979 · see citing works
A General Definition of Residuals
Cox, D. R., & Snell, E. J. (1968) · Journal of the Royal Statistical Society Series B (Statistical Methodology) · doi:10.1111/j.2517-6161.1968.tb00724.x · Cited by 1,324 · see citing works
A Class of Rank Test Procedures for Censored Survival Data
Harrington, D. P., & Fleming, T. R. (1982) · Biometrika · doi:10.1093/biomet/69.3.553 · Cited by 1,194 · see citing works
The challenge of new drug discovery for tuberculosis
Koul, A., Arnoult, É., Lounis, N., Guillemont, J., & Andries, K. (2011) · Nature · doi:10.1038/nature09657 · Cited by 1,044 · see citing works
Ibrahim, J. G., Chen, M., & Sinha, D. (2001) · Springer series in statistics · doi:10.1007/978-1-4757-3447-8 · Cited by 942 · see citing works
Tacconelli, E., Cataldo, M. A., Dancer, S. J., Angelis, G. D., Falcone, M., Frank, U., Kahlmeter, G., Pan, A., Petrosillo, N., Rodríguez‐Baño, J., et al. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12427 · Cited by 868 · see citing works
Survival and Event History Analysis
Aalen, O. O., Borgan, Ø., & Gjessing, H. K. (2008) · Statistics for Biology and Health · doi:10.1007/978-0-387-68560-1 · Cited by 813 · see citing works
Ibrahim, J. G., Chen, M., & Sinha, D. (2014) · Wiley StatsRef: Statistics Reference Online · doi:10.1002/9781118445112.stat06003 · Cited by 788 · see citing works
Modelling Survival Data in Medical Research
Collett, D. (2015) · Chapman & Hall/CRC eBooks · doi:10.1201/b18041 · Cited by 786 · see citing works
Duration Models: Specification, Identification and Multiple Durations
van den Berg, G. J. (2001) · Handbook of econometrics · doi:10.1016/s1573-4412(01)05008-5 · Cited by 778 · see citing works
Survival models for heterogeneous populations derived from stable distributions
Hougaard, P. (1986) · Biometrika · doi:10.1093/biomet/73.2.387 · Cited by 705 · see citing works
Global Trends in Resistance to Antituberculosis Drugs
Espinal, M., Laszlo, A., Simonsen, L., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104263441706 · Cited by 673 · see citing works
Xie, J. H., & Liu, C. (2005) · Statistics in Medicine · doi:10.1002/sim.2174 · Cited by 511 · see citing works
Frailty Models in Survival Analysis
Wienke, A. (2010) · Chapman & Hall/CRC eBooks · doi:10.1201/9781420073911 · Cited by 474 · see citing works
Analysis of survival data by the proportional odds model
Bennett, S. (1983) · Statistics in Medicine · doi:10.1002/sim.4780020223 · Cited by 466 · see citing works
Risk factors for multidrug resistant tuberculosis in Europe: a systematic review
Faustini, A. (2005) · Thorax · doi:10.1136/thx.2005.045963 · Cited by 456 · see citing works
Parametric Frailty and Shared Frailty Survival Models
Gutierrez, R. G. (2002) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0200200102 · Cited by 434 · see citing works
World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update
Falzon, D., Schünemann, H. J., Harausz, E., González-Angulo, L., Lienhardt, C., Jaramillo, E., & Weyer, K. (2017) · European Respiratory Journal · doi:10.1183/13993003.02308-2016 · Cited by 421 · see citing works
Duchateau, L., & Janssen, P. (2007) · Cited by 347 · see citing works
Okamura, R., Boichard, A., Kato, S., Sicklick, J. K., Bazhenova, L., & Kurzrock, R. (2018) · JCO Precision Oncology · doi:10.1200/po.18.00183 · Cited by 328 · see citing works
Kaplan-Meier Estimate on the Plane
Dabrowska, D. M. (1988) · The Annals of Statistics · doi:10.1214/aos/1176351049 · Cited by 321 · see citing works
A Method of Analysis of a Certain Class of Experiments in Carcinogenesis
Pike, M. C. (1966) · Biometrics · doi:10.2307/2528221 · Cited by 263 · see citing works
Brueffer, C., Vallon‐Christersson, J., Grabau, D. A., Ehinger, A., Häkkinen, J., Hegardt, C., Malina, J., Chen, Y., Bendahl, P., Manjer, J., et al. (2018) · JCO Precision Oncology · doi:10.1200/po.17.00135 · Cited by 222 · see citing works
High effectiveness of a 12-month regimen for MDR-TB patients in Cameroon
Kuaban, C., Noeske, J., Rieder, H. L., Ait-Khaled, N., Foe, J.-L. A., & Trébucq, A. (2015) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.14.0535 · Cited by 196 · see citing works
XDR-TB in South Africa: No Time for Denial or Complacency
Singh, J. A., Upshur, R. E. G., & Padayatchi, N. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040050 · Cited by 184 · see citing works
Kaplan-Meier Survival Curves and the Log-Rank Test
Kleinbaum, D. G., & Klein, M. C. (2011) · Statistics for biology and health · doi:10.1007/978-1-4419-6646-9_2 · Cited by 144 · see citing works
Estimating the median survival time
Reid, N. M. (1981) · Biometrika · doi:10.1093/biomet/68.3.601 · Cited by 141 · see citing works
A Weibull Regression Model with Gamma Frailties for Multivariate Survival Data
Sahu, S. K., Dey, D. K., Aslanidou, H., et al. (1997) · Lifetime Data Analysis · doi:10.1023/a:1009605117713 · Cited by 136 · see citing works
Tarai, B., Das, P., & Kumar, D. (2013) · Journal of Laboratory Physicians · doi:10.4103/0974-2727.119843 · Cited by 122 · see citing works
parfm: Parametric Frailty Models inR
Munda, M., Rotolo, F., & LeGrand, C. C. (2012) · Journal of Statistical Software · doi:10.18637/jss.v051.i11 · Cited by 114 · see citing works
Antimicrobial Resistance in Mycobacterium tuberculosis : The Odd One Out
Eldholm, V., & Balloux, F. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.03.007 · Cited by 104 · see citing works
Deshmukh, R. D., Dhande, D. J., Sachdeva, K. S., Sreenivas, A., Kumar, A. M. V., Satyanarayana, S., Parmar, M., Moonan, P. K., & Lo, T. Q. (2015) · PLOS ONE · doi:10.1371/journal.pone.0135802 · Cited by 99 · see citing works
Cox, H. S., McDermid, C., Azevedo, V. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013901 · Cited by 92 · see citing works
Brust, J. C. M., Gandhi, N. R., Carrara, H., et al. (2010) · PubMed · Cited by 89 · see citing works
Modelling heterogeneity in survival data
Hougaard, P. (1991) · Journal of Applied Probability · doi:10.2307/3214503 · Cited by 81 · see citing works
Kaplan-Meier Survival Curves and the Log-Rank Test
Kleinbaum, D. G. (1996) · Springer eBooks · doi:10.1007/978-1-4757-2555-1_2 · Cited by 60 · see citing works
Parmar, M., Sachdeva, K. S., Dewan, P. K., Rade, K., Nair, S. A., Pant, R., & Khaparde, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193903 · Cited by 58 · see citing works
Parve, S., Ershadi, A., Karimov, A., et al. (2016) · African Health Sciences · doi:10.4314/ahs.v16i2.29 · Cited by 56 · see citing works
Hamusse, S. D., Demissie, M., Teshome, D., & Lindtjørn, B. (2014) · Global Health Action · doi:10.3402/gha.v7.25382 · Cited by 49 · see citing works
Nigus, D. M. (2014) · Mycobacterial Diseases · doi:10.4172/2161-1068.1000152 · Cited by 40 · see citing works
Determinants of multidrug-resistant tuberculosis in Addis Ababa, Ethiopia
Assefa, D., Seyoum, B., & Oljira, L. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s134369 · Cited by 34 · see citing works
Proportional hazards models with discrete frailty
Caroni, C., Crowder, M., & Kimber, A. (2010) · Lifetime Data Analysis · doi:10.1007/s10985-010-9151-3 · Cited by 28 · see citing works
Alrabiah, K., Alola, S. A., Banyan, E. A., Al-Shaalan, M., & Johani, S. A. (2016) · International Journal of Pediatrics and Adolescent Medicine · doi:10.1016/j.ijpam.2016.03.006 · Cited by 25 · see citing works
Girum, T., Tariku, Y., & Dessu, S. (2017) · Annals of Medical and Health Sciences Research · Cited by 22 · see citing works
Getachew, T., Bayray, A., & Weldearegay, B. (2013) · Pharmaceutical Regulatory Affairs Open Access · Cited by 18 · see citing works
Rabie, H., Decloedt, E. H., Garcia‐Prats, A. J., et al. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1309023 · Cited by 15 · see citing works
Kundu, D., Sharma, N., Chadha, S. S., et al. (2018) · Health Economics Review · doi:10.1186/s13561-018-0187-5 · Cited by 14 · see citing works
Tyrrell, F. C., Stafford, C., Yakrus, M. A., et al. (2016) · Public Health Reports · doi:10.1177/0033354916679989 · Cited by 7 · see citing works
Parameter Estimation of Shared Frailty Models Based on Particle Swarm Optimization
Aşkın, Ö. E., İnan, D., & Büyüklü, A. H. (2016) · International Journal of Statistics and Probability · doi:10.5539/ijsp.v6n1p48 · Cited by 6 · see citing works
Brookmeyer, R. (2014) · Wiley StatsRef: Statistics Reference Online · doi:10.1002/9781118445112.stat06043 · Cited by 5 · see citing works
Swain, P. K., & Grover, G. (2016) · Turkiye Klinikleri Journal of Biostatistics · doi:10.5336/biostatic.2015-48400 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [19]Cochran WG Sampling Techniques 1977 3 New York Wiley
- [44]Miller Jr, R.G. Survival Analysis. Vol. 66. Chichaster: Wily; 2011.
Cited by
Sorted by citations
As'hab, P. P., Keliat, B. A., & Wardani, I. Y. (2022) · Journal of Public Health Research · doi:10.4081/jphr.2021.2737 · Cited by 16 · see citing works
“Positive questions (1, 3, 5, 6, 8, 10, 13, 15, 19) answers “correct” score 0 and “wrong” score 1, negative questions (2, 4, 7, 9, 11, 12, 14, 16, 17, 18, 20) answer “correct” is worth 1 and “false” is worth 0.”
Background
- Authors
- Limenih, Y. A., & Workie, D. L.
- Affiliations
- Bahir Dar University (ET)
- Corresponding author
- Workie, Demeke Lakew
- ORCID
- Workie, Demeke Lakew
- Venue
- BMC Public Health
- Published
- 2019-02-07
- Volume
- 19
- Issue
- 1
- Pages
- 165-165
- ISSN
- 1471-2458 (ISSN-L)
- PMC
- PMC6367739
- OpenAlex
- W2918285439
- Cited by
- 27
- References
- 56
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 11 · 2020: 3
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Public Health (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Keywords
- multidrug-resistant tuberculosis, time to cure, recovery time, extrapulmonary tuberculosis, pulmonary tuberculosis, medication adherence, comorbidities, medical complications, smoking, shared frailty model, Amhara region
- MeSH terms
- Ethiopia, Female, Humans, Male, Retrospective Studies, Time Factors, Survival Analysis, Treatment Outcome, Tuberculosis, Multidrug-Resistant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
