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Effect of fruit and mint flavored Rogue® oral nicotine product use on smoking reduction and quitting in a 6-Month prospective cohort of adults who smoke cigarettes

McDowell, Elliott H., Kennedy, Jason N., Feehan, Michael, Bell, Stacey A., Marking, Sarah E., Zdinak, Jessica P., Joyce, Andrew R., Humphreys, Michelle·2024·BMC Public Health
DOI 10.1186/s12889-024-20463-3PMC PMC11583794

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Abstract

Background: Quitting cigarette smoking can substantially reduce or eliminate the risk of developing numerous chronic diseases. Use of flavored tobacco or nicotine products is commonly cited by adults who smoke cigarettes to be important in helping them reduce or quit smoking. The purpose of this analysis was to understand the association between the levels of use of flavored oral nicotine products and smoking reduction and quitting and how reduction or quitting may differ between predominant users of fruit/other versus mint flavored oral nicotine products after six months of use. Methods: Participants were provided with their choice of a variety of forms and flavors of Rogue ® nicotine products (Study Products) over a 6-month actual use period and completed online surveys assessing tobacco, nicotine and Study Product use at Baseline and Months 1, 2, 4, and 6 thereafter. Results: Among the 1393 participants at Month 6, 41.4% and 52.5% used predominantly fruit/other or mint Study Product flavors, respectively. Compared to predominant mint users, predominant fruit/other users had greater cigarette reduction (mean reduction: 50.0% vs. 48.4%) and a higher proportion had quit smoking (proportion quit: 15.4% vs. 11.6%) at Month 6. Additionally, 38.8% of predominant fruit/other users and 39.3% of predominant mint users reduced their cigarette consumption by ≥ 50% from Baseline. Increased use of fruit/other flavors was independently associated with smoking reduction (8.6% greater reduction per 10 pieces/day; p < 0.001) and odds of quitting smoking (OR = 1.29 [95% CI: 1.04–1.59] per 10 pieces/day; p = 0.017). Increased use of mint flavors was independently associated with smoking reduction (7.5% greater reduction per 10 mint pieces/day; p < 0.001) but not with odds of quitting smoking. Conclusions: Increased use of either fruit/other or mint flavored Study Products at Month 6 was associated with significantly increased smoking reduction, whereas only increased use of fruit/other flavors was associated with greater odds of quitting smoking among participants in the study. Trial Registration: This study was observational. Participants were not prospectively assigned to one or more health-related interventions and could choose to use or not use the commercially available study products provided during the study. Thus, the study was not registered in a trial database by the Sponsor.

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  • There are higher odds of quitting smoking after switching to fruit-flavored ONPs (OR = 1.29; 95% CI: 1.04-1.59; p = 0.017), but not after switching to mint-flavored ONPs (OR = 1.04; 95% CI: 0.82-1.28; p = 0.75).

    “A higher odds of quitting smoking (OR = 1.29; 95% CI: 1.04-1.59;p = 0.017) after switching to fruit-flavored ONPs, but not after switching to mint-flavored ONPs (OR = 1.04; 95% CI: 0.82-1.28;p = 0.75) (McDowell et al. 2024)”

    From Comparison of the Health Effects Associated with the Use of Snus and Tobacco-Free Oral Nicotine Pouches: A Systematic Review (2026) · cites this paper as McDowell et al. 2024

  • Switching to fruit-flavored ONPs for 6 months leads to greater reduction of conventional cigarette smoking (8.6% greater reduction per 10 pieces/day; p < 0.001) compared to switching to mint-flavored ONP (7.5% greater reduction per 10 mint pieces/day; p < 0.001).

    “Switching to fruit-flavored ONPs for 6 months led to greater reduction of CC smoking (8.6% greater reduction per 10 pieces/day; p < 0.001) compared to switching to mint-flavored ONP (7.5% greater reduction per 10 mint pieces/day; p < 0.001) (McDowell et al. 2024)”

    From Comparison of the Health Effects Associated with the Use of Snus and Tobacco-Free Oral Nicotine Pouches: A Systematic Review (2026) · cites this paper as McDowell et al. 2024

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Cited by

Sorted by citations

Authors
McDowell, E. H., Kennedy, J. N., Feehan, M., Bell, S. A., Marking, S. E., Zdinak, J. P., Joyce, A. R., & Humphreys, M.
Venue
BMC Public Health
Publisher
Springer Science and Business Media LLC
Published
2024-11-22
Volume
24
Issue
1
ISSN
1471-2458
DOI
10.1186/s12889-024-20463-3
PMC
PMC11583794
Cited by
3
References
2
Language
en
Licence
Funders
Rogue Holdings LLC

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