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Cited by 73Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisIL-33, ST2, and ILC PathwaysSystemic Sclerosis and Related Diseases

Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis

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Lee, Jong-Uk, Chang, Hun Soo, Lee, Hyeon Ju, Jung, Chang An, Bae, Da Jeong, Song, Hyun Ji, Park, Jong Sook, Uh, Soo-Taek +3 more·2017·BMC Pulmonary Medicine
DOI 10.1186/s12890-017-0380-zPMC PMC5312598
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Abstract

BACKGROUND: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19). RESULTS: The TSLP and IL-33 levels were significantly higher in patients with IPF relative to the NCs (p = 0.01 and p = 0.0001, respectively), NSIP (p = 4.95E - 7 and p = 0.0002, respectively), HP (p = 0.00003 and p = 0.000005, respectively), and sarcoidosis groups (p = 0.003 and p = 0.0001, respectively). However, the IL-25 levels were not significantly different between NC and IPF group (p = 0.432). Receiver operating characteristic curves of the TSLP and IL-33 levels revealed clear differences between the IPF and NC groups (AUC = 0.655 and 0.706, respectively), as well as between the IPF and the other lung disease groups (AUC = 0.786 and 0.781, respectively). Cut-off values of 3.52 pg/μg TSLP and 3.77 pg/μg IL-33 were shown to differentiate between the IPF and NC groups with 99.2 and 94.3% accuracy. Cut-off values of 4.66 pg/μg TSLP and 2.52 pg/μg IL-33 possessed 99.4 and 93.2% accuracy for differentiating among the IPF and other interstitial lung disease groups. CONCLUSIONS: Innate immune responses may be associated with the development of IPF. Furthermore, the IL-33 and TSLP levels in BAL fluids may be useful for differentiating IPF from other chronic interstitial lung diseases.

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Authors
Lee, J.-U., Chang, H. S., Lee, H. J., Jung, C. A., Bae, D. J., Song, H. J., Park, J. S., Uh, S.-T., Kim, Y. H., Seo, K.-H., & Park, C.-S.
Affiliations
  • Soonchunhyang University (KR)
  • Soonchunhyang University Hospital Bucheon (KR)
Corresponding author
Park, Choon-Sik
ORCID
Venue
BMC Pulmonary Medicine
Publisher
Springer Science and Business Media LLC
Published
2017-02-15
Volume
17
Issue
1
Pages
39-39
ISSN
1471-2466 (ISSN-L)
DOI
10.1186/s12890-017-0380-z
PMC
PMC5312598
OpenAlex
W2589097271
Cited by
73
References
49
Citations by year
2026: 4 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 13 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 2
FWCI
5.66
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Pulmonary Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (2013R1A2A2A01068077)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Keywords
idiopathic pulmonary fibrosis, IL-33, thymic stromal lymphopoietin, IL-25, Th2 immune response, bronchoalveolar lavage fluid, interstitial lung disease, nonspecific interstitial pneumonia, hypersensitivity pneumonitis, sarcoidosis, diagnostic biomarkers, differential diagnosis, innate immunity, lung fibrosis pathogenesis
MeSH terms
Interleukin-33, Thymic Stromal Lymphopoietin, Adult, Aged, Aged, 80 and over, Alveolitis, Extrinsic Allergic, Animals, Bronchoalveolar Lavage Fluid, False Positive Reactions, Female, Humans, Immunity, Innate, Lung, Male, Middle Aged, Pneumonia, ROC Curve, Sarcoidosis, Up-Regulation, Case-Control Studies, Cytokines, Idiopathic Pulmonary Fibrosis, Republic of Korea

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