TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

Ito, Tomoki; Wang, Yui-Hsi; Duramad, Omar; Hori, Toshiyuki; Delespesse, Guy J.; Watanabe, Norihiko; Qin, F. Xiao-Feng; Yao, Zhengbin; Cao, Wei; Liu, Yong-Jun

doi:10.1084/jem.20051135

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

We recently showed that dendritic cells (DCs) activated by thymic stromal lymphopoietin (TSLP) prime naive CD4+ T cells to differentiate into T helper type 2 (Th2) cells that produced high amounts of tumor necrosis factor-α (TNF-α), but no interleukin (IL)-10. Here we report that TSLP induced hum…