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Cited by 18Hormonal Regulation and HypertensionAdrenal and Paraganglionic TumorsAdrenal Hormones and Disorders

High body fat percentage is associated with primary aldosteronism: a cross-sectional study

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Manosroi, Worapaka, Atthakomol, Pichitchai·2020·BMC Endocrine Disorders
DOI 10.1186/s12902-020-00654-wPMC PMC7686735
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Abstract

Background: Excess aldosterone has been shown to be associated with obesity; however, there is currently a lack of data regarding the relationship between percentage of body fat and primary aldosteronism (PA), particularly pertaining to Asian populations. Furthermore, essential hypertension may mimic the condition of PA and there needs to be differentiation between the two. This study aimed to assess the association between percentage of body fat and PA. Methods: A cross-sectional study was conducted in the outpatient department of the Endocrine and Metabolism Unit of the tertiary care medical center in Thailand. Data was obtained from 79 patients who had been screened for PA due to hypertension in young-onset, hypokalemia, adrenal incidentaloma or resistance hypertension. Essential hypertension was defined as patients who had high blood pressure and were negative for PA screening. Body fat percentage was assessed by bioelectrical impedance analysis. The relationship between percentage of body fat and a diagnosis of PA was assessed using logistic regression analysis, including adjustment for confounding factors. Results: The participants were divided into a PA group (n = 41) and an essential hypertension group (n = 38). After controlling for confounding variables (age, sex, body mass index, cholesterol and insulin resistance status), the odds ratio of having PA in males with a percentage of body fat > 25% and females with percentage > 30% was 1.82 (95%CI = 1.79–1.86, p < 0.001). Conclusion: A higher percentage of body fat is associated with an increased risk of PA. Further studies need to be conducted to confirm the relationship between body fat percentage and PA.

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  • Body Fat Percentage provides a more precise assessment of body composition than BMI.

    “Body Fat Percentage measures the proportion of fat relative to total body weight, providing a more precise assessment of body composition than BMI.”

    From Advantages and Limitations of the Body Mass Index (BMI) to Assess Adult Obesity (2024) · cites this paper as [68]

    The Methods section measures percentage body fat separately from BMI. The Discussion says BMI may underestimate body fat content in Asian populations, supporting a narrower comparison, but it does not establish that body-fat percentage is generally a more precise assessment of body composition than BMI. Page numbers are unavailable in our copy. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Manosroi, W., & Atthakomol, P.
Affiliations
Chiang Mai University (TH)
Corresponding author
Manosroi, Worapaka
ORCID
Venue
BMC Endocrine Disorders
Publisher
Springer Science and Business Media LLC
Published
2020-11-23
Volume
20
Issue
1
Pages
175-175
ISSN
1472-6823 (ISSN-L)
DOI
10.1186/s12902-020-00654-w
PMC
PMC7686735
OpenAlex
W3107216544
Cited by
18
References
1
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5
FWCI
1.70
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Endocrine Disorders (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
primary aldosteronism, body fat percentage, obesity, essential hypertension, hypokalemia, adrenal incidentaloma, young-onset hypertension, Asian populations, aldosterone, sex differences
MeSH terms
Adipose Tissue, Adult, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Hyperaldosteronism, Male, Obesity, Prognosis, Thailand

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