Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: A randomized clinical trail
Open accessAbstract
BACKGROUND: Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis. METHODS: In this randomized, double-blind study, 40 chronic periodontitis patients underwent non-surgical therapy and were randomly assigned to two intervention and control groups, receiving either resveratrol supplements or a placebo for four weeks. Salivary levels of interleukin-8 (IL-8), interleukin-1β (IL-1β), and clinical parameters, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured before and after the intervention. RESULTS: The results showed that in both the case and control groups, after four weeks of using resveratrol, only plaque index (PI) was significantly different compared to the control group (P = 0.0001). However, there were no significant differences in the mean pocket depth (PD), clinical attachment loss (CAL), bleeding index (BI), and salivary levels of IL-8 and IL-1β between the two groups after the intervention. CONCLUSION: Resveratrol complement was helpful as an anti-inflammatory food supplement, along with other non-surgical periodontal treatments in chronic periodontitis patients.
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Periodontal examinations used the Ramfjord index to evaluate six specific teeth.
“Periodontal examinations were performed by utilizing the Ramfjord index,[23] which is a comprehensive method of evaluating the depth of the periodontal pockets and the degree of attachment loss in six specific teeth within the oral cavity.”
From The effect of text message-based health guidelines reinforcement on clinical outcomes following non-surgical periodontal therapy: A randomized clinical trial (2025) · cites this paper as [23]
The Methods > Periodontal examination section (page unavailable) describes measuring probing depth at six points of each tooth, not examining six specific teeth with the Ramfjord index. It also records attachment loss at those sites and says 10 points were randomly selected for post-intervention measurements. (LLM, conf=0.88)
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Cites
O’Leary, T. J., Drake, R. B., & Naylor, J. E. (1972) · Journal of Periodontology · doi:10.1902/jop.1972.43.1.38 · Cited by 2,552 · see citing works
The Coxibs, Selective Inhibitors of Cyclooxygenase-2
FitzGerald, G. A., & Patrono, C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108093450607 · Cited by 1,572 · see citing works
Navazesh, M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18343.x · Cited by 1,449 · see citing works
Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line
How, K. Y., Song, K. P., & Chan, K. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00053 · Cited by 858 · see citing works
Cancer Chemopreventive Activity of Resveratrol
Bhat, K. P. L., & Pezzuto, J. (2002) · Drugs under experimental and clinical research · doi:10.1111/j.1749-6632.2002.tb02918.x · Cited by 633 · see citing works
Potential of resveratrol in anticancer and anti-inflammatory therapy
Udenigwe, C. C., Ramprasath, V. R., Aluko, R. E., & Jones, P. J. H. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00076.x · Cited by 314 · see citing works
Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis
Bhattarai, G., Poudel, S. B., Kook, S., & Lee, J. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.031 · Cited by 245 · see citing works
Teles, R., Likhari, V., Socransky, S., & Haffajee, A. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01119.x · Cited by 209 · see citing works
Reactive oxygen species in periodontitis
Dahiya, P., Kamal, R., Gupta, R., Bhardwaj, R., Chaudhary, K., & Kaur, S. (2013) · Journal of Indian Society of Periodontology · doi:10.4103/0972-124x.118306 · Cited by 200 · see citing works
Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis
Preshaw, P. M., Hefti, A. F., Jepsen, S. V., Etienne, D. H., Walker, C., & Bradshaw, M. H. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00558.x · Cited by 170 · see citing works
Periodontitis and Accelerated Biological Aging: A Geroscience Approach
Baima, G., Romandini, M., Citterio, F., Romano, F., & Aimetti, M. (2021) · Journal of Dental Research · doi:10.1177/00220345211037977 · Cited by 119 · see citing works
Corrêa, M. G., Pires, P. R., Ribeiro, F. V., Pimentel, S. Z., Casarin, R. C. V., Cirano, F. R., Tenenbaum, H. C., & Casati, M. Z. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12382 · Cited by 114 · see citing works
Javid, A. Z., Hormoznejad, R., Yousefimanesh, H. A., Zakerkish, M., Haghighizadeh, M. H., Dehghan, P., & Ravanbakhsh, M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5737 · Cited by 110 · see citing works
Millhouse, E., Jose, A., Sherry, L., Lappin, D. F., Patel, N. A., Middleton, A. M., Pratten, J. R., Culshaw, S., & Ramage, G. (2014) · BMC Oral Health · doi:10.1186/1472-6831-14-80 · Cited by 87 · see citing works
Casati, M. Z., Algayer, C., da Cruz, G. C., Ribeiro, F. V., Casarin, R. C. V., Pimentel, S. P., & Cirano, F. R. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.120746 · Cited by 83 · see citing works
Kaymaz, K., Hensel, A., & Beikler, T. (2018) · Fitoterapia · doi:10.1016/j.fitote.2018.11.012 · Cited by 78 · see citing works
Dietary Polyphenols and Periodontitis—A Mini-Review of Literature
Basu, A., Masek, E., & Ebersole, J. L. (2018) · Molecules · doi:10.3390/molecules23071786 · Cited by 70 · see citing works
Javid, A. Z., Hormoznejad, R., Yousefimanesh, H. A., Haghighizadeh, M. H., & Zakerkish, M. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.07.042 · Cited by 59 · see citing works
Curcumin for the Management of Periodontal Diseases: A Review
Forouzanfar, F., Forouzanfar, A., Sathyapalan, T., Orafai, H. M., & Sahebkar, A. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200513112607 · Cited by 54 · see citing works
Holzhausen, M., Spolidório, D. M. P., Muscará, M. N., Hebling, J., & Spolidório, L. C. (2005) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2005.00787.x · Cited by 52 · see citing works
Is change in probing depth a reliable predictor of change in clinical attachment loss?
Michalowicz, B. S., Hodges, J. S., & Pihlstrom, B. L. (2013) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2013.0096 · Cited by 45 · see citing works
Queiroz‐Junior, C. M., Pacheco, C. M. D. F., Maltos, K. L. M., Caliari, M. V., Duarte, I. D. G., & Francischi, J. N. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2007.01069.x · Cited by 45 · see citing works
Chin, Y., Hsieh, M.-T., Lin, C., Kuo, P., Yang, Y. S. H., Shih, Y.-J., Lai, H.-Y., Cheng, G., Tang, H.-Y., Lee, C., et al. (2016) · Mediators of Inflammation · doi:10.1155/2016/6953459 · Cited by 38 · see citing works
Andrade, E. F., Orlando, D. R., Araújo, A. M. S., de Andrade, J. N. B. M., Azzi, D. V., de Lima, R. R., Júnior, A. R. L., & Pereira, L. J. (2019) · Nutrients · doi:10.3390/nu11050953 · Cited by 35 · see citing works
Gurgel, B. C. D. V., Duarte, P. M., Nociti, F. H., Sallum, E. A., Casati, M. Z., Sallum, A. W., & de Toledo, S. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.12.1613 · Cited by 32 · see citing works
The effect of systemic administration of ibuprofen in the experimental gingivitis model
Sekino, S., Ramberg, P., & Lindhe, J. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00671.x · Cited by 25 · see citing works
Ou, L., & Li, R.-F. (2011) · PubMed · Cited by 22 · see citing works
Anti-histaminic Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts
Farzanegan, A., Shokouhian, M., Jafari, S., Shirazi, F. S., & Shahidi, M. (2019) · Inflammation · doi:10.1007/s10753-019-01023-z · Cited by 18 · see citing works
Shahidi, M., Vaziri, F., Haerian, A., Farzanegan, A., Jafari, S., Sharifi, R., & Shirazi, F. S. (2017) · Europe PMC (PubMed Central) · Cited by 17 · see citing works
Resveratrol as a supplemental treatment for periodontitis
Khazaei, S., Khazaei, M., Kazemi, S., & Yaghini, J. (2012) · Dental Research Journal · doi:10.4103/1735-3327.104891 · Cited by 10 · see citing works
Castellino, G., Mesa, F., Cappello, F., Benavides-Reyes, C., Malfa, G., Cabello, I., & Magán-Fernández, A. (2021) · Applied Sciences · doi:10.3390/app11209563 · Cited by 9 · see citing works
The polymicrobial synergy and dysbiosis model of periodontal disease pathogenesis
Hajishengallis, G., & Lamont, R. J. (2016) · doi:10.1002/9781118982907.ch14 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [24]Dwarakanath CD. Carranza’s clinical Periodontology-Ebook: third south Asia Edition. Elsevier Health Sciences; 2019.
- [34]Paul AM, Victor DJ, Gana Prakash PS. Role of Interleukin-8 in Periodontal Disease. International Journal of Clinical Dental Science. 2012;3(2).
Cited by
Sorted by citations
Zhao, W., Zhang, Y. L., Chen, J., & Hu, D. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103451 · Cited by 61 · see citing works
Adjunctive Therapies in Periodontitis: Current Concepts and the Future
de Molon, R. S., Steffens, J. P., de Ávila, É. D., Teughels, W., & Dyke, T. E. V. (2026) · Journal of Periodontal Research · doi:10.1111/jre.70060 · Cited by 25 · see citing works
Microbiota and Resveratrol: How Are They Linked to Osteoporosis?
Meyer, C., Brockmueller, A., de Porras, V. R., & Shakibaei, M. (2024) · Cells · doi:10.3390/cells13131145 · Cited by 21 · see citing works
Le, F., Wang, T., Liu, Y. Q., Ma, M., Liu, G., Wang, Y., Xia, J., Gu, Z., & Hao, Z. (2025) · ACS Nano · doi:10.1021/acsnano.5c08885 · Cited by 21 · see citing works
Periodontitis Continuum: Antecedents, Triggers, Mediators, and Treatment Strategies
Benahmed, A. G., Tippairote, T., Gasmi, A., Noor, S., Avdeev, O. V., Shanaida, Y., Mojgani, N., Emadali, A., Dadar, M., & Bjørklund, G. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673265862231020051338 · Cited by 21 · see citing works
Research progress on the role and mechanism of Sirtuin family in doxorubicin cardiotoxicity
Zhang, X., Huang, C., Hou, Y., Jiang, S., Zhang, Y., Wang, S., Chen, J., Lai, J., Wu, L., Duan, H., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155673 · Cited by 12 · see citing works
de Molon, R. S. (2025) · Dentistry Journal · doi:10.3390/dj13070309 · Cited by 9 · see citing works
de Molon, R. S., Rodrigues, J. V. S., de Ávila, É. D., Barbirato, D. D. S., Moura, J. P. F., Monteiro, G. V., Alves, M. V., Theodoro, L. H., Vernal, R., & Teughels, W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052394 · Cited by 8 · see citing works
Luchesi, V. H., Giorgetti, A. P. O., Corrêa, M. G., Pecorari, V. G. A., Benatti, B. B., Tenenbaum, H. C., Cirano, F. R., Pimentel, S. P., & Casati, M. Z. (2025) · Clinical Oral Investigations · doi:10.1007/s00784-025-06517-9 · Cited by 7 · see citing works
Rahbardar, M. G., Kesharwani, P., & Sahebkar, A. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106800 · Cited by 6 · see citing works
Resveratrol facilitates bone formation in high-glucose conditions
Hwang, S., Kim, T., Kim, A., Kim, Y., Park, J., Lee, J., Kim, J., & Suh, J. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1347756 · Cited by 7 · see citing works
Bastin, A., Netticadan, T., Abbasi, F., Rahimi, N., Mahmoodi, M., Alizadeh, M., Movahed, A., & Momeni‐Moghaddam, M. A. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05290-3 · Cited by 5 · see citing works
Salvatori, R., Generali, L., Bellei, E., Bergamini, S., & Bertoldi, C. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70096 · Cited by 4 · see citing works
Vinciguerra, C., Bellia, L., Corbi, G., Rengo, S., & Cannavò, A. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.11.017 · Cited by 3 · see citing works
V-ATPase and Lysosomal Energy Sensing in Periodontitis and Medicine-Related Osteonecrosis of the Jaw
Yang, X., & Holliday, L. S. (2025) · Biomolecules · doi:10.3390/biom15070997 · Cited by 3 · see citing works
Ramachandran, P., Angelin Fiona, J., Balaji, A., Anandkumar, M., Mubarak, S., & Balakrishnan, D. (2025) · Journal of Advanced Oral Research · doi:10.1177/23202068251405551 · Cited by 2 · see citing works
Resveratrol and Curcumin: Extending the Frontier of Phytomedicine
Harney, T. L. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006617 · Cited by 2 · see citing works
Arunachalam, L. T., Suresh, S., Lavu, V., & Vedamanickam, S. (2024) · Journal Of Biochemical Technology · doi:10.51847/qe4kzck2dj · Cited by 2 · see citing works
Tu, C., Luo, Y., Jiang, T., Yang, Z., Yang, B., Zhang, K., Zhang, J. M., Hu, C., Zhou, L. P., Qiu, T., et al. (2025) · Clinical Cosmetic and Investigational Dentistry · doi:10.2147/ccide.s560013 · Cited by 1 · see citing works
de Molon, R. S., Scarel‐Caminaga, R. M., Caldeira, F. I. D., Ervolino, E., de Ávila, É. D., Barbugli, P. A., Oliveira, G. E., Franco‐Moura, J. P., Theodoro, L. H., Cirelli, J. A., et al. (2026) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.70159 · Cited by 1 · see citing works
Nibali, L., Kang, J. X., Haworth, S. J., Polizzi, A., & Isola, G. (2026) · Journal of Periodontal Research · doi:10.1111/jre.70168 · Cited by 1 · see citing works
Evaluation of Periodontitis Prevention by Using Traditional Medicinal Plants
Pillalamarri, M., Harika, P., Gojuvaka, S., Saba, S., Dasari, U. D., & Lolla, S. (2024) · International Journal of TROPICAL DISEASE & Health · doi:10.9734/ijtdh/2024/v45i51533 · Cited by 1 · see citing works
Vaziri, F., Eidi, M., Maybodi, F. R., Dehkordi, N. R., & Khoddami, N. (2025) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_1408_24
“[25] All patients underwent scaling and root planning using an ultrasonic scaler (ultrasonic piezo scaler Uds‑”
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Hernández-Monjaraz, B. (2024) · Casos y Revisiones de Salud · doi:10.22201/fesz.26831422e.2024.6.1s.1
Bioprospecting Nutraceuticals for Human Welfare
Hegde, M., Mishra, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2024) · Springer eBooks · doi:10.1007/978-3-031-71674-4_16
Walsh, L. J., & Seneviratne, C. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13821-8.00009-3
Mimiroğlu, D., & Zabcı, S. (2025) · Anatolian Journal of Pharmaceutical Sciences · doi:10.71133/anatphar.1730860
Wu, L., Yuan, Y., & Yu, Y. (2025) · Lasers in Medical Science · doi:10.1007/s10103-025-04752-w
Yu, J., Cao, Z., Zhang, X., Zheng, L., Zhu, L. X., Zhuang, Y., & Liu, Z. H. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116933
Resveratrol and its effects on healthy aging
Mendoza-Núñez, V. M., García-Martínez, B. I., & Ruíz-Ramos, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29192-0.00036-4
Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis
Su, S. Y., Tzeng, I., Huang, T.-H., & Fu, E. (2026) · Nutrients · doi:10.3390/nu18132212
Belenichev, I., Popazova, O., Дмитрієва, О., Chertov, S. O., Bukhtiyarova, N., Ryzhenko, V. P., Oliynyk, S., Lee, S., & Yi, K. (2026) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2026.1849807
Wang, J., Zhang, X., Zhang, Y., Wang, X., Yang, B., Hu, X., Mao, J., Zhang, Z., & Li, H. (2026) · Biomolecules · doi:10.3390/biom16091334
Wang, Y., Yi, Y., Liu, Y., Cai, W., Zhao, Y., Zhang, W., Wu, Z., Wang, Y., & Zhang, L. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.117261
Belenichev, I., Popazova, O., Salnykov, V., Bukhtiyarova, N., Ryzhenko, V., Petakh, P., Kamyshnyi, O., Oliynyk, S., Lee, S., & Yi, K. (2026) · Cureus · doi:10.7759/cureus.118234
- Authors
- Nikniaz, S., Vaziri, F., & Mansouri, R.
- Affiliations
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
- Corresponding author
- Vaziri, Farzane
- Venue
- BMC Oral Health
- Published
- 2023-03-27
- Volume
- 23
- Issue
- 1
- Pages
- 177-177
- ISSN
- 1472-6831 (ISSN-L)
- PMC
- PMC10045616
- OpenAlex
- W4360998982
- Cited by
- 35
- References
- 33
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 10 · 2023: 1
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Oral Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Shahid Sadoughi University of Medical Sciences
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- resveratrol, chronic periodontitis, dietary supplementation, anti-inflammatory activity, interleukin-8, IL-1β, plaque index, probing depth, clinical attachment level, bleeding index, non-surgical periodontal therapy
- MeSH terms
- Resveratrol, Dental Plaque Index, Humans, Inflammation, Interleukin-8, Periodontal Attachment Loss, Dietary Supplements, Chronic Periodontitis
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