The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Peto’s Paradox: how has evolution solved the problem of cancer prevention?
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Altogether, the weak correlation between body mass and somatic mutation rates after correction for lifespan suggests that the evolution of larger body sizes may have relied on alternative or additional strategies to limit cancer risk, as has been speculated24,42 (Supplementary Note 2).”
From Somatic mutation rates scale with lifespan across mammals (2022) · cites this paper as [24]
The cited source says what the claim attributes to it.
In the citing paper
“This observation, known as Peto’s paradox, suggests that the evolution of larger body sizes is likely to require the evolution of stronger cancer suppression mechanisms23,24.”
From Somatic mutation rates scale with lifespan across mammals (2022) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 1×
“For instance, it was found that genetically altering mice to overexpress a form of the TP53 protein conferred a cancer-suppressive phenotype; however, these mice also displayed a premature ageing phenotype [18].”
BackgroundBenson, R. B. J., Campione, N. E., Carrano, M. T., Mannion, P. D., Sullivan, C., Upchurch, P., & Evans, D. C. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001853 · Cited by 457
Flagged first, then by citations
Research works printed but not linked: 29
- Peto R, Roe FJ, Lee PN, Levy L, Clack J. Cancer and ageing in mice and men. Br J Cancer. 1975;32:411–26. · DOI · Paper page
- Peto R. Epidemiology, multistage models, and short-term mutagenicity tests. In: Hiatt HH, Watson JD, Winstein JA, editors. The origins of human cancer. New York: Cold Spring Harbor Laboratory; 1977. p. 1403–28.
- Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74. · DOI · Paper page
- Caulin AF, Graham TA, Wang L-S, Maley CC. Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis. Phil Trans R Soc B. 2015;370:20140222. · DOI
- Abegglen LM, Caulin AF, Chan A, Lee K, Robinson R, Campbell MS, et al. Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. JAMA. 2015;314:1850–60. · DOI · Paper page
- Roche B, Hochberg ME, Caulin AF, Maley CC, Gatenby RA, Misse D, et al. Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox. BMC Cancer. 2012;12:387. · DOI
- Sulak M, Fong L, Mika K, Chigurupati S, Yon L, Mongan NP, et al. TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. Elife. 2016;5:1850.
- Yim H-S, Cho YS, Guang X, Kang SG, Jeong J-Y, Cha S-S, et al. Minke whale genome and aquatic adaptation in cetaceans. Nat Genet. 2014;46:88–92. · DOI
- Keane M, Semeiks J, Webb AE, Li YI, Quesada V, Craig T, et al. Insights into the evolution of longevity from the bowhead whale genome. Cell Rep. 2015;10:112–22. · DOI · Paper page
- Kingsolver JG, Pfennig DW. Individual level selection as a cause of Cope's Rule of phyletic size increase. Evolution. 2004;58:1608–12. · DOI
- Heim NA, Knope ML, Schaal EK, Wang SC, Payne JL. Cope’s rule in the evolution of marine animals. Science. 2015;347:867–70. · DOI
- Baker J, Meade A, Pagel M, Venditti C. Adaptive evolution toward larger size in mammals. Proc Natl Acad Sci U S A. 2015;112:5093–8. · DOI
- Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, et al. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A. 2009;106:19352–7. · DOI
- Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013;499:346–9. · DOI
- Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, et al. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A. 2012;109:19392–6. · DOI
- Nagy JD, Victor EM, Cropper JH. Why don't all whales have cancer? A novel hypothesis resolving Peto's paradox. Am Zool. 2007;47:317–28.
- García-Cao I, Cao MG, Caballero JM, Criado LM, Klatt P, Flores JM, et al. “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 2002;21:6225–35. · DOI · Paper page
- Møller AP, Erritzøe J, Soler JJ. Life history, immunity, Peto's paradox and tumours in birds. J Evol Biol. 2017;30:960–7. · DOI
- Martineau D, Lemberger K, Dallaire A, Labelle P, Lipscomb TP, Michel P, et al. Cancer in wildlife, a case study: beluga from the St. Lawrence estuary, Québec, Canada. Environ Health Perspect. 2002;110:285–92. · DOI
- Boddy AM, Kokko H, Breden F, Wilkinson GS, Aktipis CA. Cancer susceptibility and reproductive trade-offs: a model of the evolution of cancer defences. Phil Trans R Soc B. 2015;370:20140220. · DOI
- Brown JS, Aktipis CA. Inclusive fitness effects can select for cancer suppression into old age. Phil Trans R Soc B. 2015;370:20150160. · DOI
- Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 1957;11:398–411. · DOI · Paper page
- Effron M, Griner L, Benirschke K. Nature and rate of neoplasia found in captive wild mammals, birds, and reptiles at necropsy. J Natl Cancer Inst. 1977;59:185–98. · DOI
- Rothschild BM, Tanke DH, Helbling M, Martin LD. Epidemiologic study of tumors in dinosaurs. Naturwissenschaften. 2003;90:495–500. · DOI
- Barbosa FH de S, Pereira PVLG de C, Bergqvist LP, Rothschild BM. Multiple neoplasms in a single sauropod dinosaur from the Upper Cretaceous of Brazil. Cretaceous Res. 2016;62:13–7. · DOI
- Woodward HN, Freedman Fowler EA, Farlow JO, Horner JR. Maiasaura, a model organism for extinct vertebrate population biology: a large sample statistical assessment of growth dynamics and survivorship. Paleobiology. 2015;41:503–27. · DOI
- Aktipis CA, Boddy AM, Jansen G, Hibner U, Hochberg ME, Maley CC, et al. Cancer across the tree of life: cooperation and cheating in multicellularity. Phil Trans R Soc B. 2015;370:20140219–9. · DOI · Paper page
- De Vos JM, Joppa LN, Gittleman JL, Stephens PR, Pimm SL. Estimating the normal background rate of species extinction. Conserv Biol. 2015;29:452–62. · DOI
- Vanderven E, Burns ME, Currie PJ, Farke A. Histologic growth dynamic study of Edmontosaurus regalis (Dinosauria: Hadrosauridae) from a bonebed assemblage of the Upper Cretaceous Horseshoe Canyon Formation, Edmonton, Alberta, Canada. Can J of Earth Sci. 2014;51:1023–33. · DOI
Cited by
Sorted by citations
Somatic mutation rates scale with lifespan across mammals
Cagan, A., Baez-Ortega, A., Brzozowska, N., Abascal, F., Coorens, T. H. H., Sanders, M. A., Lawson, A. R. J., Harvey, L. M. R., Bhosle, S., Jones, D., et al. (2022) · Nature · doi:10.1038/s41586-022-04618-z · Cited by 481
Metadata
- Authors
- Tollis, M., Boddy, A. M., & Maley, C. C.
- Venue
- BMC Biology
- Published
- 2017-07-13
- Volume
- 15
- Issue
- 1
- ISSN
- 1741-7007
- PMC
- PMC5513346
- Cited by
- 88
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
