The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Antibodies against H10N8 avian influenza virus among animal workers in Guangdong Province before November 30, 2013, when the first human H10N8 case was recognized
Open accessAbstract
BACKGROUND: Considered an epicenter of pandemic influenza virus generation, southern China has recently seen an increasing number of human H7N9 infections. However, it is not the only threat. On 30 November 2013, a human H10N8 infection case was first described in China. The origin and genetic diversity of this novel virus is similar to that of H7N9 virus. As H10N8 avian influenza virus (AIV) was first identified from a duck in Guangdong Province during 2012 and there is also evidence of H10N8 infected dogs in this region, we sought to examine archived sera from animal workers to see if there was evidence of subclinical human infections before the first human H10N8 cases. METHODS: We studied archived serum samples (cross-sectional study, convenience sample) collected between May and September 2013 from 710 animal workers and 107 non-animal exposed volunteers living in five cities of Guangdong Province. Study participants' sera were tested by horse red blood cells (RBCs) hemagglutination inhibition (HI) and microneutralization (MN) assays according to World Health Organization guidelines. The A/Jiangxi-Donghu/346-1/2013(H10N8) virus was used. Sera which have an HI assay ≥1:20 were further tested with the MN assay. Questionnaire data were examined for risk factor associations with positive serological assays. Risk factor analyses failed to identify specific factors associated with probable H10N8 infections. RESULTS: Among the 827 sera, only 21 animal workers had an HI titer ≥1:20 (18 had an HI titer of 1:20 and 3 had an HI titer of 1:40). None of these 21 subjects reported experiencing any influenza symptoms during the three months before enrollment. Among the three subjects with HI titers of 1:40, two had MN antibody titers of 1:40, and one had a MN antibody titer of 1:80 (probable H10N8 infections). CONCLUSIONS: Study data suggest that animal workers may have been infected with the H10N8 virus before the first recognized H10N8 human infection cases. It seems prudent to continue surveillance for H10N8 viruses among animal workers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Given the rarity of H9, H6 and H10 human infections, the binding antibodies likely represent heterosubtypic immunity elicited by vaccination or exposure to other influenza A subtypes.
“Given the rarity of H9, H6 and H10 human infections23–25 it is likely the binding antibodies represent heterosubtypic immunity elicited by vaccination or exposure to other influenza A subtypes.”
From Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice (2025) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Centers for Disease Control and Prevention
Branum, A. (2007) · Sage eBooks · doi:10.4135/9781412952644.n74 · Cited by 6,434
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Gao, R., Cao, B., Hu, Y., Feng, Z., Wang, D., Hu, W., Chen, J., Jie, Z., Qiu, H., Xu, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304459 · Cited by 2,310
Chen, H., Yuan, H., Gao, R., Zhang, J., Wang, D., Xiong, Y., Fan, G., Yang, F., Li, X., Zhou, J., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60111-2 · Cited by 648
Self-citationThe Role of the Antibody Response in Influenza Virus Infection
Gerhard, W. (2001) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-05783-4_9 · Cited by 211
INFLUENZAVIRUS INFECTIONS IN SEATTLE FAMILIES, 1975–1979
Fox, J. P., Cooney, M. K., HALL, C. E., & Foy, H. M. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113408 · Cited by 198
Emergence in China of human disease due to avian influenza A(H10N8) – Cause for concern?
To, K. K., Tsang, A. K. L., Chan, J. F., Cheng, V. C., Chen, H., & Yuen, K. (2014) · Journal of Infection · doi:10.1016/j.jinf.2013.12.014 · Cited by 122
Update: Isolation of Avian Influenza A(H5N1) Viruses From Humans—Hong Kong, 1997-1998
(1998) · JAMA · doi:10.1001/jama.279.5.347 · Cited by 111
The next influenza pandemic: lessons from Hong Kong
Shortridge, K. F., Peiris, M. J. S., & Guan, Y. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.94.s1.8.x · Cited by 110
Yang, S., Chen, Y., Cui, D., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit430 · Cited by 106
Qi, W., Zhou, X., Shi, W., et al. (2014) · Eurosurveillance · doi:10.2807/1560-7917.es2014.19.25.20841 · Cited by 99
Self-citationAvian influenza A H10N8—a virus on the verge?
García‐Sastre, A., & Schmolke, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60163-x · Cited by 64
Wang, X., Fang, S., Lü, X., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu399 · Cited by 64
Su, S., Qi, W., Zhou, P., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu345 · Cited by 61
Self-citationSu, S., Zhou, P., Fu, X., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu154 · Cited by 53
Self-citationJiao, P., Cao, L., Yuan, R., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00959-12 · Cited by 37
Complete Genome Sequence of an Avian-Like H4N8 Swine Influenza Virus Discovered in Southern China
Su, S., Qi, W., Chen, J.-D., et al. (2012) · Journal of Virology · doi:10.1128/jvi.01475-12 · Cited by 37
Self-citationSu, S., Chen, J.-D., Qi, H.-T., et al. (2012) · Journal of Virology · doi:10.1128/jvi.01315-12 · Cited by 34
Self-citationJiao, P., Yuan, R., Wei, L., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00963-12 · Cited by 11
Flagged first, then by citations
Cited by
Sorted by citations
HUANG, S. Y., YANG, J. R., LIN, Y. J., YANG, C. H., CHENG, M. C., LIU, M. T., WU, H. S., & CHANG, F. Y. (2015) · Epidemiology and Infection · doi:10.1017/s0950268815000394 · Cited by 31
Hawman, D. W., Tipih, T., Hodge, E., Stone, E. T., Warner, N., McCarthy, N., Granger, B., Meade-White, K., Leventhal, S., Hatzakis, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55546-7 · Cited by 20
Metadata
- Authors
- Qi, W., Su, S., Xiao, C., Zhou, P., Li, H., Ke, C., Gray, G. C., Zhang, G., & Liao, M.
- Affiliations
- South China Agricultural University (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Duke University (US)
- Corresponding author
- Zhang, Guihong
- Liao, Ming
- ORCID
- Venue
- BMC Medicine
- Published
- 2014-10-27
- Volume
- 12
- Issue
- 1
- Pages
- 205-205
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC4219099
- OpenAlex
- W2027567662
- Cited by
- 15
- References
- 19
- Citations by year
- 2025: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2016: 2 · 2015: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Florida Digital Collections (University of Florida) (submittedVersion, other-oa)
- National University of Singapore (submittedVersion, cc-by)
- Funders
- Chinese Academy of Sciences (CARS-36)
- Natural Science Foundation of Guangdong Province (CARS-36)
- University of Hong Kong
- Modern Agricultural Technology Industry System of Shandong province (CARS-36)
- Institute of Microbiology, Chinese Academy of Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- seroprevalence, asymptomatic infection, hemagglutination inhibition antibodies, occupational exposure, Guangdong, influenza surveillance, H7N9, zoonotic transmission, infection risk factors
- MeSH terms
- Agriculture, Animals, Antibodies, Viral, China, Cross-Sectional Studies, Female, Humans, Influenza, Human, Male, Zoonoses, Seroepidemiologic Studies, Veterinarians, Young Adult, Influenza A Virus, H7N9 Subtype, Influenza A Virus, H10N8 Subtype
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
