The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study
Open accessAbstract
BACKGROUND: Cardiovascular factors and low education are important risk factors of dementia. We provide contemporary estimates of the proportion of dementia cases that could be prevented if modifiable risk factors were eliminated, i.e., population attributable risk (PAR). Furthermore, we studied whether the PAR has changed across the last two decades. METHODS: We included 7,003 participants of the original cohort (starting in 1990) and 2,953 participants of the extended cohort (starting in 2000) of the Rotterdam Study. Both cohorts were followed for dementia until ten years after baseline. We calculated the PAR of overweight, hypertension, diabetes mellitus, cholesterol, smoking, and education. Additionally, we assessed the PAR of stroke, coronary heart disease, heart failure, and atrial fibrillation. We calculated the PAR for each risk factor separately and the combined PAR taking into account the interaction of risk factors. RESULTS: During 57,996 person-years, 624 participants of the original cohort developed dementia, and during 26,177 person-years, 145 participants of the extended cohort developed dementia. The combined PAR in the original cohort was 0.23 (95 % CI, 0.05-0.62). The PAR in the extended cohort was slightly higher at 0.30 (95 % CI, 0.06-0.76). The combined PAR including cardiovascular diseases was 0.25 (95 % CI, 0.07-0.62) in the original cohort and 0.33 (95 % CI, 0.07-0.77) in the extended cohort. CONCLUSIONS: A substantial part of dementia cases could be prevented if modifiable risk factors would be eliminated. Although prevention and treatment options of cardiovascular risk factors and diseases have improved, the preventive potential for dementia has not declined over the last two decades.
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The Rotterdam Study: objectives and design update
Hofman, A., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9199-x · Cited by 1,395
Self-citationMatthews, F. E., Arthur, A., Barnes, L. E., Bond, J., Jagger, C., Robinson, L., & Brayne, C. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61570-6 · Cited by 1,155
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Cited by
Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125
Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
Biessels, G. J., & Despa, F. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0048-7 · Cited by 1,454
The changing prevalence and incidence of dementia over time - current evidence
Wu, Y.-T., Beiser, A. S., Breteler, M. M. B., Fratiglioni, L., Helmer, C., Hendrie, H. C., Honda, H., Ikram, M. A., Langa, K. M., Lobo, A., et al. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.63 · Cited by 775
Self-citationvan der Flier, W. M., Skoog, I., Schneider, J. A., Pantoni, L., Mok, V., Chen, C. L. H., & Scheltens, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.3 · Cited by 594
Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441
Metadata
- Authors
- de Bruijn, R. F., Bos, M. J., Portegies, M. L., Hofman, A., Franco, O. H., Koudstaal, P. J., & Ikram, M. A.
- Venue
- BMC Medicine
- Published
- 2015-07-21
- Volume
- 13
- Issue
- 1
- Pages
- 132-132
- ISSN
- 1741-7015 (ISSN-L)
- OpenAlex
- W1592173539
- Cited by
- 270
- References
- 35
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- de Bruijn, R. F., Bos, M. J., Portegies, M. L., Hofman, A., Franco, O. H., Koudstaal, P. J., & Ikram, M. A. (2015). The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study. BMC Medicine. https://doi.org/10.1186/s12916-015-0377-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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