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The Rotterdam Study: objectives and design update
Open accessAbstract
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over 1200 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.
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Self-citationPrevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study
Heeringa, J., van der Kuip, D. A. M., Hofman, A., Kors, J. A., van Herpen, G., Stricker, B. H. C., Stijnen, T., Lip, G. Y. H., & Witteman, J. C. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi825 · Cited by 1,939
Self-citationArterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
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- Visser LE, van Schaik RH, van Vliet M, Trienekens PH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. Thromb Haemost 2004;92:61–6. · DOI
- Visser LE, Bleumink GS, Trienekens PH, Vulto AG, Hofman A, Stricker BHCh. The risk of overanticoagulation in patients with heart failure on coumarin anticoagulants. Br J Haematol 2004;127:85–9. · DOI
- Visser LE, van Schaik RHN, van Vliet M, Trienekens PH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants. Clin Pharmacol Ther 2005;77:479–85. · DOI
- Bleumink GS, Schut AF, Sturkenboom MC, van Duijn CM, Deckers JW, Hofman A, Kingma JH, Witteman JC, Stricker BHCh. Mortality in patients with hypertension on ACE-inhibitor treatment is influenced by the ACE I/D polymorphism. Pharmacogenet Genomics 2005;15:75–81. · DOI
- Visser LE, Trienekens PH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants. Pharmacogenet Genomics 2005;15:69–74. · DOI
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Self-citation
Metadata
- Authors
- Hofman, A., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M.
- Venue
- European Journal of Epidemiology
- Published
- 2007-10-23
- Volume
- 22
- Issue
- 11
- Pages
- 819-829
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- OpenAlex
- W2109252993
- Cited by
- 1,395
- References
- 41
- FWCI
- 54.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- creativecommons.org/licenses/by-nc/2.0 (tdm)
- creativecommons.org/licenses/by-nc/2.0 (vor)
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- CoChat. (2026). Citation check: The Rotterdam Study: objectives and design update. https://app.cochat.ai/papers/10.1007/s10654-007-9199-x
- The paper
- Hofman, A., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M. (2007). The Rotterdam Study: objectives and design update. European Journal of Epidemiology. https://doi.org/10.1007/s10654-007-9199-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.