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The Rotterdam Study: objectives and design update

Open access
Hofman, Albert, Breteler, Monique M. B., van Duijn, Cornelia M., Krestin, Gabriel P., Pols, Huibert A., Stricker, Bruno H. Ch., Tiemeier, Henning, Uitterlinden, André G., Vingerling, Johannes R., Witteman, Jacqueline C. M.·2007·European Journal of Epidemiology

Abstract

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over 1200 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

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Research works printed but not linked: 79

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  61. Despriet DD, Klaver CC, Witteman JC, Bergen AA, Kardys I, de Maat MP, Boekhoorn SS, Vingerling JR, Hofman A, Oostra BA, Uitterlinden AG, Stijnen T, van Duijn CM, de Jong PT. Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. JAMA 2006;296:301–9. · DOI · Paper page
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  63. Fang Y, van Meurs JB, d’Alesio A, Jhamai M, Zhao H, Rivadeneira F, Hofman A, van Leeuwen JP, Jehan F, Pols HA, Uitterlinden AG. Promoter and 3′ UTR haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam Study Am J Hum Genet 2005;77:807–23. · DOI · Paper page
  64. Feenstra J, Heerdink ER, Grobbee DE, Stricker BHCh. Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure. Arch Int Med 2002;162:265–70. · DOI · Paper page
  65. Straus SM, Kors JA, de Bruin ML, van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom JCM, Stricker BHCh, Witteman JCM. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006;47:362–7. · DOI · Paper page
  66. Van der Hooft CS, Heeringa J, Brusselle GG, Hofman A, Witteman JCM, Kingma JH, Sturkenboom MCJM, Stricker BHCh. Corticosteroids and the risk of atrial fibrillation. Arch Int Med 2006;165:1016–20. · DOI · Paper page
  67. Schoofs MWCJ, van der Klift M, Hofman A, de Laet CEDH, Herings RMC, Stijnen Th, Pols HAP, Stricker BHCh. Thiazide diuretics and the risk for hip fracture. Ann Intern Med 2003;139:476–82. · DOI · Paper page
  68. Schoofs MW, Sturkenboom MCJM, van der Klift M, Hofman A, Pols HA, Stricker BHCh. HMG-CoA reductase inhibitors and the risk of vertebral fracture. J Bone Miner Res 2004;19:1525–30. · DOI
  69. Reijman M, Bierma-Zeinstra SM, Pols HAP, Koes BW, Stricker BHCh, Hazes JM. Is there an association between the use of different types of NSAIDs and radiologic progression of osteoarthritis ? The Rotterdam Study. Arthritis Rheum 2005;52:3137–42. · DOI
  70. Van Leeuwen R, Vingerling JR, Hofman A, de Jong PTVM, Stricker BHCh. Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement. BMJ 2003;326:255–6. · DOI
  71. Visser LE, Penning-van Beest FJA, Kasbergen AAH, De Smet PAGM, Vulto AG, Hofman A, Stricker BHCh. Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants. Clin Pharmacol Ther 2002;71:496–502. · DOI
  72. Visser LE, Penning-van Beest FJA, Kasbergen HAA, De Smet PAGM, Vulto AG, Hofman A, Stricker BHCh. Overanticoagulation associated with combined use of antibacterial agents and acenocoumarol or phenprocoumon anticoagulants. Thromb Haemost 2002;88:705–10. · DOI
  73. Visser LE, van Vliet M, van Schaik RHN, Kasbergen AAH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. Pharmacogenetics 2004;14:27–33. · DOI
  74. Visser LE, Penning-van Beest FJ, Wilson JHP, Vulto AG, Kasbergen AA, de Smet PAGM, Hofman A, Stricker BHCh. Overanticoagulation associated with combined use of lactulose and coumarin anticoagulants. Br J Clin Pharmacol 2004;57:522–4. · DOI
  75. Visser LE, van Schaik RH, van Vliet M, Trienekens PH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. Thromb Haemost 2004;92:61–6. · DOI
  76. Visser LE, Bleumink GS, Trienekens PH, Vulto AG, Hofman A, Stricker BHCh. The risk of overanticoagulation in patients with heart failure on coumarin anticoagulants. Br J Haematol 2004;127:85–9. · DOI
  77. Visser LE, van Schaik RHN, van Vliet M, Trienekens PH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants. Clin Pharmacol Ther 2005;77:479–85. · DOI
  78. Bleumink GS, Schut AF, Sturkenboom MC, van Duijn CM, Deckers JW, Hofman A, Kingma JH, Witteman JC, Stricker BHCh. Mortality in patients with hypertension on ACE-inhibitor treatment is influenced by the ACE I/D polymorphism. Pharmacogenet Genomics 2005;15:75–81. · DOI
  79. Visser LE, Trienekens PH, de Smet PAGM, Vulto AG, Hofman A, van Duijn CM, Stricker BHCh. Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants. Pharmacogenet Genomics 2005;15:69–74. · DOI

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Metadata

Authors
Hofman, A., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M.
Venue
European Journal of Epidemiology
Published
2007-10-23
Volume
22
Issue
11
Pages
819-829
ISSN
  • 0393-2990 (ISSN-L)
  • 1573-7284
OpenAlex
W2109252993
Cited by
1,395
References
41
FWCI
54.22
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: The Rotterdam Study: objectives and design update. https://app.cochat.ai/papers/10.1007/s10654-007-9199-x
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Hofman, A., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M. (2007). The Rotterdam Study: objectives and design update. European Journal of Epidemiology. https://doi.org/10.1007/s10654-007-9199-x

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