The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
PARP inhibitors in the management of breast cancer: current data and future prospects
Open accessAbstract
Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers. We herein review the development of PARP inhibitors and the basis for the excitement surrounding these agents, their use as single agents and in combinations, as well as their toxicities, mechanisms of acquired resistance, and companion diagnostics.
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Cites
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Cited by
Manahan, E. R., Kuerer, H. M., Sebastian, M., Hughes, K. S., Boughey, J. C., Euhus, D. M., Boolbol, S. K., & Taylor, W. A. (2019) · Annals of Surgical Oncology · doi:10.1245/s10434-019-07549-8 · Cited by 346
PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting
Dziadkowiec, K. N., Gąsiorowska, E., Nowak-Markwitz, E., & Jankowska, A. (2016) · Menopausal Review · doi:10.5114/pm.2016.65667 · Cited by 191
Targeting DNA Damage Response and Immune Checkpoint for Anticancer Therapy
Huang, J.-L., Chang, Y.-T., Hong, Z.-Y., & Lin, C.-S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063238 · Cited by 42
Nogalski, M. T., & Shenk, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017734117 · Cited by 25
Metadata
- Authors
- Livraghi, L., & Garber, J. E.
- Venue
- BMC Medicine
- Published
- 2015-08-13
- Volume
- 13
- Issue
- 1
- Pages
- 188-188
- ISSN
- 1741-7015 (ISSN-L)
- OpenAlex
- W1928092242
- Cited by
- 269
- References
- 109
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- Livraghi, L., & Garber, J. E. (2015). PARP inhibitors in the management of breast cancer: current data and future prospects. BMC Medicine. https://doi.org/10.1186/s12916-015-0425-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
