Cited by 25DNA Repair MechanismsGenomics and Chromatin DynamicsCytomegalovirus and herpesvirus research

HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement

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Nogalski, Maciej T., Shenk, Thomas·2020·Proceedings of the National Academy of Sciences

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Abstract

Significance: HSATII RNA is associated with cancer progression and immunostimulation, and as we recently reported, it plays an important role in herpesvirus infections. However, our understanding of cellular processes responsible for the expression of HSATII RNA is limited. Our current investigation identified a noncanonical, ATM kinase-independent DNA damage response pathway as a common cellular mechanism regulating HSATII RNA induction in virus-infected cells or cells treated with DNA-damaging agents. Additionally, our study provides a link between expression of HSATII RNA and the cellular growth and migration phenotypes of cancer cells, establishing a paradigm to study the biological consequences of HSATII RNA expression, i.e., treatment of normal diploid and tumor cells with DNA-damaging agents.

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Crossref · 10.1073/pnas.2017734117

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Authors
Nogalski, M. T., & Shenk, T.
Affiliations
Princeton University (US)
Corresponding author
  • Nogalski, Maciej T.
  • Shenk, Thomas
Venue
Proceedings of the National Academy of Sciences
Published
2020-11-30
Volume
117
Issue
50
Pages
31891-31901
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W3109989542
Cited by
25
References
120
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 5
FWCI
1.46
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • HHS | National Institutes of Health (AI112951, AI142520)
  • American Cancer Society (PF-14-116-01-MPC)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords
ATM kinase, DNA damage response, human cytomegalovirus, viral replication, cell migration, cell proliferation, breast cancer, colon cancer, pericentromeric repeats, etoposide, zeocin
MeSH terms
RNA-Seq, Bleomycin, Breast Neoplasms, Cell Movement, Cytomegalovirus Infections, DNA Damage, DNA Repair, DNA, Satellite, Etoposide, Female, Humans, Repetitive Sequences, Nucleic Acid, Transcriptional Activation, Gene Expression Regulation, Neoplastic, Disease Progression, RNA, Untranslated, Cell Line, Tumor, Cell Proliferation, Gene Knockdown Techniques, Genetic Fitness, Ataxia Telangiectasia Mutated Proteins

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